THE PROTECTIVE ROLE OF TANNIC ACID AGAINST POSSIBLE HEPATO-NEPHROTOXICITY INDUCED BY SILVER NANOPARTICLES ON MALE RATS
Silver nanoparticles (AgNPs) are being used extensively for biomedical purposes regarding to their broad antimicrobial activity, however their toxicity has been addressed in only few studies. In the present study, we aimed to prepare and characterize AgNPs, investigate their adverse effect on liver...
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| Format: | Article |
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Association of medical doctors Sanamed Novi Pazar
2019-09-01
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| Series: | Sanamed |
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| Online Access: | http://www.sanamed.rs/OJS/index.php/Sanamed/article/view/336/167 |
| _version_ | 1797287373670711296 |
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| author | Mosa F Israa Youssef Mokhtar Shalaby Thanaa Mosa F Osama |
| author_facet | Mosa F Israa Youssef Mokhtar Shalaby Thanaa Mosa F Osama |
| author_sort | Mosa F Israa |
| collection | DOAJ |
| description | Silver nanoparticles (AgNPs) are being used extensively for biomedical purposes regarding to their broad antimicrobial activity, however their toxicity has been addressed in only few studies. In the present study, we aimed to prepare and characterize AgNPs, investigate their adverse effect on liver and kidney functions, and also elucidate the hepato-nephro protective ability of tannic acid in male rats. The obtained results showed that AgNPs caused oxidative stress throughout the induction of thiobarbituric acid-reactive substances (TBARS) and the reduction of the activities of antioxidant enzymes (GST, SOD, CAT, GPx) and the levels of glutathione. Hepatic markers enzymes (AST, ALT, ALP, ACP, LDH and GGT), total bilirubin, urea, creatinine and lipid profile were increased, while hematological parameters were decreased. Histopathological investigations indicated marked degeneration of hepatocytes, endothelial cells of renal which with its role has confirmed the hepatotoxicity and nephrotoxicity induced by AgNPs. The presence of tannic acid along with AgNPs showed obvious improvements in the injured liver and kidney tissues. The protective effect of tannic acid against the toxicity of AgNPs might be due to its antioxidant properties and scavenging abilities against active free radicals. |
| first_indexed | 2024-03-07T18:32:13Z |
| format | Article |
| id | doaj.art-8a2bac4b66394ea6bb282c48ecb2dd6a |
| institution | Directory Open Access Journal |
| issn | 1452-662X 2217-8171 |
| language | English |
| last_indexed | 2024-03-07T18:32:13Z |
| publishDate | 2019-09-01 |
| publisher | Association of medical doctors Sanamed Novi Pazar |
| record_format | Article |
| series | Sanamed |
| spelling | doaj.art-8a2bac4b66394ea6bb282c48ecb2dd6a2024-03-02T05:58:13ZengAssociation of medical doctors Sanamed Novi PazarSanamed1452-662X2217-81712019-09-0114213114510.24125/sanamed.v14i2.336THE PROTECTIVE ROLE OF TANNIC ACID AGAINST POSSIBLE HEPATO-NEPHROTOXICITY INDUCED BY SILVER NANOPARTICLES ON MALE RATSMosa F Israa0Youssef Mokhtar1Shalaby Thanaa2Mosa F Osama3Department of Environmental Studies, Institute of Graduate Studies and Research, Alexandria University, Alexandria, EgyptDepartment of Environmental Studies, Institute of Graduate Studies and Research, Alexandria University, Alexandria, EgyptDepartment of Biophysics, Medical Research Institute, Alexandria University Alexandria, Egypt Department of Public Health, Health Sciences College at Leith, Umm Al Qura University, Al-Leith, Makkah, Saudi ArabiaSilver nanoparticles (AgNPs) are being used extensively for biomedical purposes regarding to their broad antimicrobial activity, however their toxicity has been addressed in only few studies. In the present study, we aimed to prepare and characterize AgNPs, investigate their adverse effect on liver and kidney functions, and also elucidate the hepato-nephro protective ability of tannic acid in male rats. The obtained results showed that AgNPs caused oxidative stress throughout the induction of thiobarbituric acid-reactive substances (TBARS) and the reduction of the activities of antioxidant enzymes (GST, SOD, CAT, GPx) and the levels of glutathione. Hepatic markers enzymes (AST, ALT, ALP, ACP, LDH and GGT), total bilirubin, urea, creatinine and lipid profile were increased, while hematological parameters were decreased. Histopathological investigations indicated marked degeneration of hepatocytes, endothelial cells of renal which with its role has confirmed the hepatotoxicity and nephrotoxicity induced by AgNPs. The presence of tannic acid along with AgNPs showed obvious improvements in the injured liver and kidney tissues. The protective effect of tannic acid against the toxicity of AgNPs might be due to its antioxidant properties and scavenging abilities against active free radicals.http://www.sanamed.rs/OJS/index.php/Sanamed/article/view/336/167Silver nanoparticlesTannic acidnanotoxicologyHepatotoxicityrenal damageReactive oxygen speciesDNA oxidationoxidative stresshistopathological architecture |
| spellingShingle | Mosa F Israa Youssef Mokhtar Shalaby Thanaa Mosa F Osama THE PROTECTIVE ROLE OF TANNIC ACID AGAINST POSSIBLE HEPATO-NEPHROTOXICITY INDUCED BY SILVER NANOPARTICLES ON MALE RATS Sanamed Silver nanoparticles Tannic acid nanotoxicology Hepatotoxicity renal damage Reactive oxygen species DNA oxidation oxidative stress histopathological architecture |
| title | THE PROTECTIVE ROLE OF TANNIC ACID AGAINST POSSIBLE HEPATO-NEPHROTOXICITY INDUCED BY SILVER NANOPARTICLES ON MALE RATS |
| title_full | THE PROTECTIVE ROLE OF TANNIC ACID AGAINST POSSIBLE HEPATO-NEPHROTOXICITY INDUCED BY SILVER NANOPARTICLES ON MALE RATS |
| title_fullStr | THE PROTECTIVE ROLE OF TANNIC ACID AGAINST POSSIBLE HEPATO-NEPHROTOXICITY INDUCED BY SILVER NANOPARTICLES ON MALE RATS |
| title_full_unstemmed | THE PROTECTIVE ROLE OF TANNIC ACID AGAINST POSSIBLE HEPATO-NEPHROTOXICITY INDUCED BY SILVER NANOPARTICLES ON MALE RATS |
| title_short | THE PROTECTIVE ROLE OF TANNIC ACID AGAINST POSSIBLE HEPATO-NEPHROTOXICITY INDUCED BY SILVER NANOPARTICLES ON MALE RATS |
| title_sort | protective role of tannic acid against possible hepato nephrotoxicity induced by silver nanoparticles on male rats |
| topic | Silver nanoparticles Tannic acid nanotoxicology Hepatotoxicity renal damage Reactive oxygen species DNA oxidation oxidative stress histopathological architecture |
| url | http://www.sanamed.rs/OJS/index.php/Sanamed/article/view/336/167 |
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