An Efficient Synthesis of Enantiopure (R)-heteroarylpyrimidine Analogs
An efficient synthesis of enantiopure (R)-heteroarylpyrimidine analogs is described here, which involves introduction of a chiral group, formation and separation of diasteroisomers and final transformation of an amide to an ester. The absolute configuration of the enantiopure HAPs is confirmed by X-...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2013-09-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | http://www.mdpi.com/1420-3049/18/9/11144 |
| _version_ | 1818908483140976640 |
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| author | Guo-Ming Zhao Zhi-Bing Zheng Dong-Mei Zhao Xiao-Kui Wang Guang-Qiang Xia Xiu-Yan Yang Song Li |
| author_facet | Guo-Ming Zhao Zhi-Bing Zheng Dong-Mei Zhao Xiao-Kui Wang Guang-Qiang Xia Xiu-Yan Yang Song Li |
| author_sort | Guo-Ming Zhao |
| collection | DOAJ |
| description | An efficient synthesis of enantiopure (R)-heteroarylpyrimidine analogs is described here, which involves introduction of a chiral group, formation and separation of diasteroisomers and final transformation of an amide to an ester. The absolute configuration of the enantiopure HAPs is confirmed by X-ray analysis of their intermediates. |
| first_indexed | 2024-12-19T22:11:44Z |
| format | Article |
| id | doaj.art-8a33f4e2d43e4ad7aa5696328068f126 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-19T22:11:44Z |
| publishDate | 2013-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-8a33f4e2d43e4ad7aa5696328068f1262022-12-21T20:03:52ZengMDPI AGMolecules1420-30492013-09-01189111441115210.3390/molecules180911144An Efficient Synthesis of Enantiopure (R)-heteroarylpyrimidine AnalogsGuo-Ming ZhaoZhi-Bing ZhengDong-Mei ZhaoXiao-Kui WangGuang-Qiang XiaXiu-Yan YangSong LiAn efficient synthesis of enantiopure (R)-heteroarylpyrimidine analogs is described here, which involves introduction of a chiral group, formation and separation of diasteroisomers and final transformation of an amide to an ester. The absolute configuration of the enantiopure HAPs is confirmed by X-ray analysis of their intermediates.http://www.mdpi.com/1420-3049/18/9/11144anti-HBVenantiopure(R)-heteroarylpyrimidineschiral separationdiastereomer |
| spellingShingle | Guo-Ming Zhao Zhi-Bing Zheng Dong-Mei Zhao Xiao-Kui Wang Guang-Qiang Xia Xiu-Yan Yang Song Li An Efficient Synthesis of Enantiopure (R)-heteroarylpyrimidine Analogs Molecules anti-HBV enantiopure (R)-heteroarylpyrimidines chiral separation diastereomer |
| title | An Efficient Synthesis of Enantiopure (R)-heteroarylpyrimidine Analogs |
| title_full | An Efficient Synthesis of Enantiopure (R)-heteroarylpyrimidine Analogs |
| title_fullStr | An Efficient Synthesis of Enantiopure (R)-heteroarylpyrimidine Analogs |
| title_full_unstemmed | An Efficient Synthesis of Enantiopure (R)-heteroarylpyrimidine Analogs |
| title_short | An Efficient Synthesis of Enantiopure (R)-heteroarylpyrimidine Analogs |
| title_sort | efficient synthesis of enantiopure r heteroarylpyrimidine analogs |
| topic | anti-HBV enantiopure (R)-heteroarylpyrimidines chiral separation diastereomer |
| url | http://www.mdpi.com/1420-3049/18/9/11144 |
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