Anti-apoptotic BCL-2 family proteins in acute neural injury
Cell death signaling frequently converges on mitochondria, a process that is controlled by the activities of pro- and anti-apoptotic B-cell lymphoma 2 (BCL-2) proteins. In this review, we summarize current knowledge on the control of neuronal survival, development and injury by anti-apoptotic BCL-2...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-09-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00281/full |
| _version_ | 1818858168585814016 |
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| author | UJVAL eANILKUMAR Jochen H. M. Prehn |
| author_facet | UJVAL eANILKUMAR Jochen H. M. Prehn |
| author_sort | UJVAL eANILKUMAR |
| collection | DOAJ |
| description | Cell death signaling frequently converges on mitochondria, a process that is controlled by the activities of pro- and anti-apoptotic B-cell lymphoma 2 (BCL-2) proteins. In this review, we summarize current knowledge on the control of neuronal survival, development and injury by anti-apoptotic BCL-2 family proteins. We discuss overlapping and differential effects of the individual family members: BCL-2, BCL-extra long (BCL-XL), myeloid cell leukemia 1 (MCL-1) and BCL2-like 2 (BCL-W) in the control of survival during development and pathophysiological processes such as trophic factor withdrawal, ischemic injury, excitotoxicity, oxidative stress and energy stress. Finally we discuss recent evidence that several anti-apoptotic BCL-2 proteins influence mitochondrial bioenergetics and control neuronal Ca2+ homeostasis independent of their classical role in cell death signaling. |
| first_indexed | 2024-12-19T08:52:00Z |
| format | Article |
| id | doaj.art-8a3561ddfeed4830b5fc3cd88892fcc4 |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-19T08:52:00Z |
| publishDate | 2014-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-8a3561ddfeed4830b5fc3cd88892fcc42022-12-21T20:28:41ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022014-09-01810.3389/fncel.2014.00281107190Anti-apoptotic BCL-2 family proteins in acute neural injuryUJVAL eANILKUMAR0Jochen H. M. Prehn1Royal College of Surgeons in IrelandRoyal College of Surgeons in IrelandCell death signaling frequently converges on mitochondria, a process that is controlled by the activities of pro- and anti-apoptotic B-cell lymphoma 2 (BCL-2) proteins. In this review, we summarize current knowledge on the control of neuronal survival, development and injury by anti-apoptotic BCL-2 family proteins. We discuss overlapping and differential effects of the individual family members: BCL-2, BCL-extra long (BCL-XL), myeloid cell leukemia 1 (MCL-1) and BCL2-like 2 (BCL-W) in the control of survival during development and pathophysiological processes such as trophic factor withdrawal, ischemic injury, excitotoxicity, oxidative stress and energy stress. Finally we discuss recent evidence that several anti-apoptotic BCL-2 proteins influence mitochondrial bioenergetics and control neuronal Ca2+ homeostasis independent of their classical role in cell death signaling.http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00281/fullApoptosisMitochondriaBcl-2neuronal developmentneurodegeneration.neuronal injury |
| spellingShingle | UJVAL eANILKUMAR Jochen H. M. Prehn Anti-apoptotic BCL-2 family proteins in acute neural injury Frontiers in Cellular Neuroscience Apoptosis Mitochondria Bcl-2 neuronal development neurodegeneration. neuronal injury |
| title | Anti-apoptotic BCL-2 family proteins in acute neural injury |
| title_full | Anti-apoptotic BCL-2 family proteins in acute neural injury |
| title_fullStr | Anti-apoptotic BCL-2 family proteins in acute neural injury |
| title_full_unstemmed | Anti-apoptotic BCL-2 family proteins in acute neural injury |
| title_short | Anti-apoptotic BCL-2 family proteins in acute neural injury |
| title_sort | anti apoptotic bcl 2 family proteins in acute neural injury |
| topic | Apoptosis Mitochondria Bcl-2 neuronal development neurodegeneration. neuronal injury |
| url | http://journal.frontiersin.org/Journal/10.3389/fncel.2014.00281/full |
| work_keys_str_mv | AT ujvaleanilkumar antiapoptoticbcl2familyproteinsinacuteneuralinjury AT jochenhmprehn antiapoptoticbcl2familyproteinsinacuteneuralinjury |