Neonatal Sequential Organ Failure Assessment (nSOFA) Score within 72 Hours after Birth Reliably Predicts Mortality and Serious Morbidity in Very Preterm Infants
The aim of this study was to assess the applicability of the neonatal sequential organ failure assessment score (nSOFA) within 72 h after delivery as a predictor for mortality and adverse outcome in very preterm neonates. Inborn neonates <32 weeks of gestation were evaluated. The nSOFA scores wer...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/12/6/1342 |
| _version_ | 1797488324344020992 |
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| author | Ivan Berka Peter Korček Jan Janota Zbyněk Straňák |
| author_facet | Ivan Berka Peter Korček Jan Janota Zbyněk Straňák |
| author_sort | Ivan Berka |
| collection | DOAJ |
| description | The aim of this study was to assess the applicability of the neonatal sequential organ failure assessment score (nSOFA) within 72 h after delivery as a predictor for mortality and adverse outcome in very preterm neonates. Inborn neonates <32 weeks of gestation were evaluated. The nSOFA scores were calculated from medical records in the first 72 h after birth and the peak value was used for analysis. Death or composite morbidity at hospital discharge defined the adverse outcome. Composite morbidity consisted of chronic lung disease, intraventricular haemorrhage ≥grade III, periventricular leukomalacia and necrotizing enterocolitis. Among 423 enrolled infants (median birth weight 1070 g, median gestational age 29 weeks), 27 died and 91 developed composite morbidity. Death or composite morbidity was associated with organ dysfunction as assessed by nSOFA, systemic inflammatory response, and low birthweight. The score >2 was associated with OR 2.5 (CI 1.39–4.64, <i>p</i> = 0.002) for the adverse outcome. Area under the curve of ROC was 0.795 (95% CI = 0.763–0.827). The use of nSOFA seems to be reasonable for predicting mortality and morbidity in very preterm infants. It constitutes a suitable basis to measure the severity of organ dysfunction regardless of the cause. |
| first_indexed | 2024-03-10T00:01:28Z |
| format | Article |
| id | doaj.art-8a36487a68db4a3b84d1925867fb9be3 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T00:01:28Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-8a36487a68db4a3b84d1925867fb9be32023-11-23T16:16:34ZengMDPI AGDiagnostics2075-44182022-05-01126134210.3390/diagnostics12061342Neonatal Sequential Organ Failure Assessment (nSOFA) Score within 72 Hours after Birth Reliably Predicts Mortality and Serious Morbidity in Very Preterm InfantsIvan Berka0Peter Korček1Jan Janota2Zbyněk Straňák3Institute for the Care of Mother and Child, 14700 Prague, Czech RepublicInstitute for the Care of Mother and Child, 14700 Prague, Czech RepublicNeonatal Unit, Department of Obstetrics and Gynecology, Second Faculty of Medicine, Motol University Hospital, Charles University—Prague, V Uvalu 84, 15000 Prague, Czech RepublicInstitute for the Care of Mother and Child, 14700 Prague, Czech RepublicThe aim of this study was to assess the applicability of the neonatal sequential organ failure assessment score (nSOFA) within 72 h after delivery as a predictor for mortality and adverse outcome in very preterm neonates. Inborn neonates <32 weeks of gestation were evaluated. The nSOFA scores were calculated from medical records in the first 72 h after birth and the peak value was used for analysis. Death or composite morbidity at hospital discharge defined the adverse outcome. Composite morbidity consisted of chronic lung disease, intraventricular haemorrhage ≥grade III, periventricular leukomalacia and necrotizing enterocolitis. Among 423 enrolled infants (median birth weight 1070 g, median gestational age 29 weeks), 27 died and 91 developed composite morbidity. Death or composite morbidity was associated with organ dysfunction as assessed by nSOFA, systemic inflammatory response, and low birthweight. The score >2 was associated with OR 2.5 (CI 1.39–4.64, <i>p</i> = 0.002) for the adverse outcome. Area under the curve of ROC was 0.795 (95% CI = 0.763–0.827). The use of nSOFA seems to be reasonable for predicting mortality and morbidity in very preterm infants. It constitutes a suitable basis to measure the severity of organ dysfunction regardless of the cause.https://www.mdpi.com/2075-4418/12/6/1342organ dysfunction scorepreterm birthneonatal intensive care |
| spellingShingle | Ivan Berka Peter Korček Jan Janota Zbyněk Straňák Neonatal Sequential Organ Failure Assessment (nSOFA) Score within 72 Hours after Birth Reliably Predicts Mortality and Serious Morbidity in Very Preterm Infants Diagnostics organ dysfunction score preterm birth neonatal intensive care |
| title | Neonatal Sequential Organ Failure Assessment (nSOFA) Score within 72 Hours after Birth Reliably Predicts Mortality and Serious Morbidity in Very Preterm Infants |
| title_full | Neonatal Sequential Organ Failure Assessment (nSOFA) Score within 72 Hours after Birth Reliably Predicts Mortality and Serious Morbidity in Very Preterm Infants |
| title_fullStr | Neonatal Sequential Organ Failure Assessment (nSOFA) Score within 72 Hours after Birth Reliably Predicts Mortality and Serious Morbidity in Very Preterm Infants |
| title_full_unstemmed | Neonatal Sequential Organ Failure Assessment (nSOFA) Score within 72 Hours after Birth Reliably Predicts Mortality and Serious Morbidity in Very Preterm Infants |
| title_short | Neonatal Sequential Organ Failure Assessment (nSOFA) Score within 72 Hours after Birth Reliably Predicts Mortality and Serious Morbidity in Very Preterm Infants |
| title_sort | neonatal sequential organ failure assessment nsofa score within 72 hours after birth reliably predicts mortality and serious morbidity in very preterm infants |
| topic | organ dysfunction score preterm birth neonatal intensive care |
| url | https://www.mdpi.com/2075-4418/12/6/1342 |
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