Strain-dependent modifiers exacerbate familial leukemia caused by GATA1-deficiency

Strain-dependent modifiers exacerbate familial leukemia caused by GATA1-deficiency

Abstract GATA1 plays a critical role in differentiation, proliferation, and apoptosis during erythropoiesis. We developed a Gata1 knock-down allele (Gata1.05) that results in GATA1 expression at 5% of endogenous level. In female mice heterozygous for both the Gata1.05 and wild-type alleles, we obser...

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Bibliographic Details
Main Authors: Ikuo Hirano, Kanako Abe, James Douglas Engel, Masayuki Yamamoto, Ritsuko Shimizu
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Experimental Hematology & Oncology
Subjects:
Erythroid
GATA1 transcription factor
Leukemia
Modifier
Transformation
Online Access:https://doi.org/10.1186/s40164-024-00491-w

Internet

https://doi.org/10.1186/s40164-024-00491-w

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