Antihypertensive effect and mechanism of the traditional recipe of medicine food homology (Buyang Huanwu Decoction) in China: Meta analysis and network pharmacological exploration
Background: Hypertension has become a part of the lives of many people worldwide. With the development, an increasing number of people have begun to control their hypertension through products of medicine food homology, such as Buyang Huanwu Decoction (BYHWD). However, there has been no objective re...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-01-01
|
| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023106827 |
| _version_ | 1797337041554374656 |
|---|---|
| author | Bo Li Chang Lu Yibo Liu Xiaodong Wang Haiqi Fu Changyi Li Mingjuan Sun Yajun Zhang Minhui Li |
| author_facet | Bo Li Chang Lu Yibo Liu Xiaodong Wang Haiqi Fu Changyi Li Mingjuan Sun Yajun Zhang Minhui Li |
| author_sort | Bo Li |
| collection | DOAJ |
| description | Background: Hypertension has become a part of the lives of many people worldwide. With the development, an increasing number of people have begun to control their hypertension through products of medicine food homology, such as Buyang Huanwu Decoction (BYHWD). However, there has been no objective review of the regulation of hypertension by BYHWD. Methods: As of 9 October 2023, this review made a detailed search of nine databases to look for random controlled trials (RCTs) focused on the use of BYHWD for treating hypertension. This was followed by network pharmacological analysis, and molecular docking assessment using AutoDockTools to explore the mode of action. Results: BYHWD was effective in reducing SBP (MD: 0.767; 95 % CI: 0.629, 0.905; p = 0.000), DBP (MD: 0.427; 95 % CI: 0.292, 0.561; p = 0.000), 24h SBP (MD: 0.665; 95 % CI: 0.368, 0.962; p = 0.000), 24h DBP (MD: 0.547; 95 % CI: 0.318, 0.777; p = 0.000), dSBP (MD: 0.625; 95 % CI: 0.395, 0.855; p = 0.000), dDBP (MD: 0.632; 95 % CI: 0.401, 0.862; p = 0.000), nSBP (MD: 0.859; 95 % CI: 0.340, 1.377; p = 0.001), nDBP (MD: 0.704; 95 % CI: 0.297, 1.112; p = 0.001), pv (MD: 1.311; 95 % CI: 0.363, 2.259; p = 0.007) and NIHSS (MD: 1.149; 95 % CI: 0.100, 2.199; p = 0.032), and elevating CER (OR = 2.848; 95 % CI: 1.388, 5.843; p = 0.004). However, BYHWD did not significantly reduce HCY, and there was no significant difference in the incidence of AE. In terms of the mechanism of action, the main active ingredient of BYHWD is quercetin, and the core targets are AKT1, MMP9, and others. Molecular docking also showed that quercetin mainly interacts with the amino acid residue CYS-28 of MMP2. Second, the KEGG analysis showed that BYHWD mainly act on HIF-1, Apelin, and cGMP-PKG signalling pathways, and GO analysis showed that it related to the apical part of the cell, circulatory system processes, and nuclear receptor activity. Conclusion: BYHWD can lowered blood pressure, reduced plasma viscosity, and restored neurological function with good tolerability, and had no significant effect on HCY levels. This study further demonstrated that quercetin is the main active ingredient of BYHWD that acts via the AKT1 and HIF-1 signalling pathways. These results provide new guidance for people's dietary choices by the general public. |
| first_indexed | 2024-03-08T09:03:40Z |
| format | Article |
| id | doaj.art-8a39044bc12a434e82b06a2f1a333ce0 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-08T09:03:40Z |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-8a39044bc12a434e82b06a2f1a333ce02024-02-01T06:32:02ZengElsevierHeliyon2405-84402024-01-01101e23474Antihypertensive effect and mechanism of the traditional recipe of medicine food homology (Buyang Huanwu Decoction) in China: Meta analysis and network pharmacological explorationBo Li0Chang Lu1Yibo Liu2Xiaodong Wang3Haiqi Fu4Changyi Li5Mingjuan Sun6Yajun Zhang7Minhui Li8Inner Mongolia Medical University, Hohhot, 010010, China; Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine, Hohhot, 010050, ChinaInner Mongolia Medical University, Hohhot, 010010, China; Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine, Hohhot, 010050, ChinaInner Mongolia Medical University, Hohhot, 010010, China; Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine, Hohhot, 010050, ChinaInner Mongolia Medical University, Hohhot, 010010, China; Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine, Hohhot, 010050, ChinaInner Mongolia Medical University, Hohhot, 010010, China; Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine, Hohhot, 010050, ChinaInner Mongolia Medical University, Hohhot, 010010, China; Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine, Hohhot, 010050, ChinaInner Mongolia Medical University, Hohhot, 010010, China; Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine, Hohhot, 010050, ChinaInner Mongolia Medical University, Hohhot, 010010, China; Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine, Hohhot, 010050, China; Corresponding author. Inner Mongolia Medical University, Hohhot, 010010, China.Inner Mongolia Medical University, Hohhot, 010010, China; Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine, Hohhot, 010050, China; Corresponding author. Inner Mongolia Autonomous Region Hospital of Traditional Chinese Medicine, Hohhot, 010050, China.Background: Hypertension has become a part of the lives of many people worldwide. With the development, an increasing number of people have begun to control their hypertension through products of medicine food homology, such as Buyang Huanwu Decoction (BYHWD). However, there has been no objective review of the regulation of hypertension by BYHWD. Methods: As of 9 October 2023, this review made a detailed search of nine databases to look for random controlled trials (RCTs) focused on the use of BYHWD for treating hypertension. This was followed by network pharmacological analysis, and molecular docking assessment using AutoDockTools to explore the mode of action. Results: BYHWD was effective in reducing SBP (MD: 0.767; 95 % CI: 0.629, 0.905; p = 0.000), DBP (MD: 0.427; 95 % CI: 0.292, 0.561; p = 0.000), 24h SBP (MD: 0.665; 95 % CI: 0.368, 0.962; p = 0.000), 24h DBP (MD: 0.547; 95 % CI: 0.318, 0.777; p = 0.000), dSBP (MD: 0.625; 95 % CI: 0.395, 0.855; p = 0.000), dDBP (MD: 0.632; 95 % CI: 0.401, 0.862; p = 0.000), nSBP (MD: 0.859; 95 % CI: 0.340, 1.377; p = 0.001), nDBP (MD: 0.704; 95 % CI: 0.297, 1.112; p = 0.001), pv (MD: 1.311; 95 % CI: 0.363, 2.259; p = 0.007) and NIHSS (MD: 1.149; 95 % CI: 0.100, 2.199; p = 0.032), and elevating CER (OR = 2.848; 95 % CI: 1.388, 5.843; p = 0.004). However, BYHWD did not significantly reduce HCY, and there was no significant difference in the incidence of AE. In terms of the mechanism of action, the main active ingredient of BYHWD is quercetin, and the core targets are AKT1, MMP9, and others. Molecular docking also showed that quercetin mainly interacts with the amino acid residue CYS-28 of MMP2. Second, the KEGG analysis showed that BYHWD mainly act on HIF-1, Apelin, and cGMP-PKG signalling pathways, and GO analysis showed that it related to the apical part of the cell, circulatory system processes, and nuclear receptor activity. Conclusion: BYHWD can lowered blood pressure, reduced plasma viscosity, and restored neurological function with good tolerability, and had no significant effect on HCY levels. This study further demonstrated that quercetin is the main active ingredient of BYHWD that acts via the AKT1 and HIF-1 signalling pathways. These results provide new guidance for people's dietary choices by the general public.http://www.sciencedirect.com/science/article/pii/S2405844023106827BYHWDHypertensionMedicine food homologyMetaNetwork pharmacologyMolecular docking |
| spellingShingle | Bo Li Chang Lu Yibo Liu Xiaodong Wang Haiqi Fu Changyi Li Mingjuan Sun Yajun Zhang Minhui Li Antihypertensive effect and mechanism of the traditional recipe of medicine food homology (Buyang Huanwu Decoction) in China: Meta analysis and network pharmacological exploration Heliyon BYHWD Hypertension Medicine food homology Meta Network pharmacology Molecular docking |
| title | Antihypertensive effect and mechanism of the traditional recipe of medicine food homology (Buyang Huanwu Decoction) in China: Meta analysis and network pharmacological exploration |
| title_full | Antihypertensive effect and mechanism of the traditional recipe of medicine food homology (Buyang Huanwu Decoction) in China: Meta analysis and network pharmacological exploration |
| title_fullStr | Antihypertensive effect and mechanism of the traditional recipe of medicine food homology (Buyang Huanwu Decoction) in China: Meta analysis and network pharmacological exploration |
| title_full_unstemmed | Antihypertensive effect and mechanism of the traditional recipe of medicine food homology (Buyang Huanwu Decoction) in China: Meta analysis and network pharmacological exploration |
| title_short | Antihypertensive effect and mechanism of the traditional recipe of medicine food homology (Buyang Huanwu Decoction) in China: Meta analysis and network pharmacological exploration |
| title_sort | antihypertensive effect and mechanism of the traditional recipe of medicine food homology buyang huanwu decoction in china meta analysis and network pharmacological exploration |
| topic | BYHWD Hypertension Medicine food homology Meta Network pharmacology Molecular docking |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023106827 |
| work_keys_str_mv | AT boli antihypertensiveeffectandmechanismofthetraditionalrecipeofmedicinefoodhomologybuyanghuanwudecoctioninchinametaanalysisandnetworkpharmacologicalexploration AT changlu antihypertensiveeffectandmechanismofthetraditionalrecipeofmedicinefoodhomologybuyanghuanwudecoctioninchinametaanalysisandnetworkpharmacologicalexploration AT yiboliu antihypertensiveeffectandmechanismofthetraditionalrecipeofmedicinefoodhomologybuyanghuanwudecoctioninchinametaanalysisandnetworkpharmacologicalexploration AT xiaodongwang antihypertensiveeffectandmechanismofthetraditionalrecipeofmedicinefoodhomologybuyanghuanwudecoctioninchinametaanalysisandnetworkpharmacologicalexploration AT haiqifu antihypertensiveeffectandmechanismofthetraditionalrecipeofmedicinefoodhomologybuyanghuanwudecoctioninchinametaanalysisandnetworkpharmacologicalexploration AT changyili antihypertensiveeffectandmechanismofthetraditionalrecipeofmedicinefoodhomologybuyanghuanwudecoctioninchinametaanalysisandnetworkpharmacologicalexploration AT mingjuansun antihypertensiveeffectandmechanismofthetraditionalrecipeofmedicinefoodhomologybuyanghuanwudecoctioninchinametaanalysisandnetworkpharmacologicalexploration AT yajunzhang antihypertensiveeffectandmechanismofthetraditionalrecipeofmedicinefoodhomologybuyanghuanwudecoctioninchinametaanalysisandnetworkpharmacologicalexploration AT minhuili antihypertensiveeffectandmechanismofthetraditionalrecipeofmedicinefoodhomologybuyanghuanwudecoctioninchinametaanalysisandnetworkpharmacologicalexploration |