Antioxidant Properties of New Phenothiazine Derivatives
Phenothiazine and its derivatives have a number of properties that contribute to their wider practical use in the production of biologically active substances, drugs, dyes, etc. Therefore, the synthesis and study of new compounds is of great relevance. The aim of this work was to investigate the ant...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-07-01
|
| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/11/7/1371 |
| _version_ | 1797407715305193472 |
|---|---|
| author | Olesya Voronova Sergey Zhuravkov Elena Korotkova Anton Artamonov Evgenii Plotnikov |
| author_facet | Olesya Voronova Sergey Zhuravkov Elena Korotkova Anton Artamonov Evgenii Plotnikov |
| author_sort | Olesya Voronova |
| collection | DOAJ |
| description | Phenothiazine and its derivatives have a number of properties that contribute to their wider practical use in the production of biologically active substances, drugs, dyes, etc. Therefore, the synthesis and study of new compounds is of great relevance. The aim of this work was to investigate the antioxidant activity of a number of new phenothiazine derivatives. The patterns of electroreduction of oxygen and its radicals in the presence of phenothiazine derivatives in aqueous ethanol media were studied by voltammetry. The influence of various factors on antioxidant activity was considered by the methods of experiment planning. The optimal conditions for the manifestation of the antioxidant activity of phenothiazine derivatives have been found, which seems to be relevant since it opens up new possibilities for their further use as complex preparations with antioxidant activity, including in psychiatric practice. |
| first_indexed | 2024-03-09T03:46:34Z |
| format | Article |
| id | doaj.art-8a3920e97ae041bbb52a4dcd51d9a858 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-09T03:46:34Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-8a3920e97ae041bbb52a4dcd51d9a8582023-12-03T14:34:19ZengMDPI AGAntioxidants2076-39212022-07-01117137110.3390/antiox11071371Antioxidant Properties of New Phenothiazine DerivativesOlesya Voronova0Sergey Zhuravkov1Elena Korotkova2Anton Artamonov3Evgenii Plotnikov4School of Earth Sciences & Engineering, National Research Tomsk Polytechnic University, 30 Lenin Avenue, 634050 Tomsk, RussiaSchool of Nuclear Science & Engineering, National Research Tomsk Polytechnic University, 30 Lenin Avenue, 634050 Tomsk, RussiaSchool of Earth Sciences & Engineering, National Research Tomsk Polytechnic University, 30 Lenin Avenue, 634050 Tomsk, RussiaInstitute for Biomedical Problems, Russian Academy of Sciences, 76 A Khoroshevskoe, 123007 Moscow, RussiaResearch School of Chemistry & Applied Biomedical Sciences, National Research Tomsk Polytechnic University, 30 Lenin Avenue, 634050 Tomsk, RussiaPhenothiazine and its derivatives have a number of properties that contribute to their wider practical use in the production of biologically active substances, drugs, dyes, etc. Therefore, the synthesis and study of new compounds is of great relevance. The aim of this work was to investigate the antioxidant activity of a number of new phenothiazine derivatives. The patterns of electroreduction of oxygen and its radicals in the presence of phenothiazine derivatives in aqueous ethanol media were studied by voltammetry. The influence of various factors on antioxidant activity was considered by the methods of experiment planning. The optimal conditions for the manifestation of the antioxidant activity of phenothiazine derivatives have been found, which seems to be relevant since it opens up new possibilities for their further use as complex preparations with antioxidant activity, including in psychiatric practice.https://www.mdpi.com/2076-3921/11/7/1371phenothiazinephenothiazine derivativesantioxidant activityfree radicalsvoltammetry |
| spellingShingle | Olesya Voronova Sergey Zhuravkov Elena Korotkova Anton Artamonov Evgenii Plotnikov Antioxidant Properties of New Phenothiazine Derivatives Antioxidants phenothiazine phenothiazine derivatives antioxidant activity free radicals voltammetry |
| title | Antioxidant Properties of New Phenothiazine Derivatives |
| title_full | Antioxidant Properties of New Phenothiazine Derivatives |
| title_fullStr | Antioxidant Properties of New Phenothiazine Derivatives |
| title_full_unstemmed | Antioxidant Properties of New Phenothiazine Derivatives |
| title_short | Antioxidant Properties of New Phenothiazine Derivatives |
| title_sort | antioxidant properties of new phenothiazine derivatives |
| topic | phenothiazine phenothiazine derivatives antioxidant activity free radicals voltammetry |
| url | https://www.mdpi.com/2076-3921/11/7/1371 |
| work_keys_str_mv | AT olesyavoronova antioxidantpropertiesofnewphenothiazinederivatives AT sergeyzhuravkov antioxidantpropertiesofnewphenothiazinederivatives AT elenakorotkova antioxidantpropertiesofnewphenothiazinederivatives AT antonartamonov antioxidantpropertiesofnewphenothiazinederivatives AT evgeniiplotnikov antioxidantpropertiesofnewphenothiazinederivatives |