STAT3 as a potential immunotherapy biomarker in oncogene-addicted non-small cell lung cancer
Immune checkpoint blockade has modified the treatment landscape for many types of tumors, including lung cancer. Still our knowledge on the biology of the interaction between tumor cells and the microenvironment is limited, preventing the optimal use of these new compounds and the maximum benefit th...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2018-03-01
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| Series: | Therapeutic Advances in Medical Oncology |
| Online Access: | https://doi.org/10.1177/1758835918763744 |
| _version_ | 1818283363658629120 |
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| author | Ilaria Attili Niki Karachaliou Laura Bonanno Jordi Berenguer Jillian Bracht Jordi Codony-Servat Carles Codony-Servat Masaoki Ito Rafael Rosell |
| author_facet | Ilaria Attili Niki Karachaliou Laura Bonanno Jordi Berenguer Jillian Bracht Jordi Codony-Servat Carles Codony-Servat Masaoki Ito Rafael Rosell |
| author_sort | Ilaria Attili |
| collection | DOAJ |
| description | Immune checkpoint blockade has modified the treatment landscape for many types of tumors, including lung cancer. Still our knowledge on the biology of the interaction between tumor cells and the microenvironment is limited, preventing the optimal use of these new compounds and the maximum benefit that the patients can derive from them. We have actively worked on the role of STAT3, a transcriptional factor that causes innate resistance to targeted therapies in oncogene-addicted tumors. In this short review we take the opportunity to express our opinion and review existing knowledge on the immune role of STAT3 and the possible implications that this may have for the discovery of new biomarkers to predict response to immunotherapy, as well as new partners to combine with and increase the efficacy of immune checkpoint inhibitors. |
| first_indexed | 2024-12-13T00:35:43Z |
| format | Article |
| id | doaj.art-8a40357bb4a041a0b88554f6436e9a5e |
| institution | Directory Open Access Journal |
| issn | 1758-8359 |
| language | English |
| last_indexed | 2024-12-13T00:35:43Z |
| publishDate | 2018-03-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Medical Oncology |
| spelling | doaj.art-8a40357bb4a041a0b88554f6436e9a5e2022-12-22T00:05:13ZengSAGE PublishingTherapeutic Advances in Medical Oncology1758-83592018-03-011010.1177/1758835918763744STAT3 as a potential immunotherapy biomarker in oncogene-addicted non-small cell lung cancerIlaria AttiliNiki KarachaliouLaura BonannoJordi BerenguerJillian BrachtJordi Codony-ServatCarles Codony-ServatMasaoki ItoRafael RosellImmune checkpoint blockade has modified the treatment landscape for many types of tumors, including lung cancer. Still our knowledge on the biology of the interaction between tumor cells and the microenvironment is limited, preventing the optimal use of these new compounds and the maximum benefit that the patients can derive from them. We have actively worked on the role of STAT3, a transcriptional factor that causes innate resistance to targeted therapies in oncogene-addicted tumors. In this short review we take the opportunity to express our opinion and review existing knowledge on the immune role of STAT3 and the possible implications that this may have for the discovery of new biomarkers to predict response to immunotherapy, as well as new partners to combine with and increase the efficacy of immune checkpoint inhibitors.https://doi.org/10.1177/1758835918763744 |
| spellingShingle | Ilaria Attili Niki Karachaliou Laura Bonanno Jordi Berenguer Jillian Bracht Jordi Codony-Servat Carles Codony-Servat Masaoki Ito Rafael Rosell STAT3 as a potential immunotherapy biomarker in oncogene-addicted non-small cell lung cancer Therapeutic Advances in Medical Oncology |
| title | STAT3 as a potential immunotherapy biomarker in oncogene-addicted non-small cell lung cancer |
| title_full | STAT3 as a potential immunotherapy biomarker in oncogene-addicted non-small cell lung cancer |
| title_fullStr | STAT3 as a potential immunotherapy biomarker in oncogene-addicted non-small cell lung cancer |
| title_full_unstemmed | STAT3 as a potential immunotherapy biomarker in oncogene-addicted non-small cell lung cancer |
| title_short | STAT3 as a potential immunotherapy biomarker in oncogene-addicted non-small cell lung cancer |
| title_sort | stat3 as a potential immunotherapy biomarker in oncogene addicted non small cell lung cancer |
| url | https://doi.org/10.1177/1758835918763744 |
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