Stability of standardized uptake values for quantitative bone SPECT for jawbone lesions: a single-center cross-sectional study
Abstract Background The long time required for bone uptake of radiopharmaceutical material after injection for bone scintigraphy is a burden for patients with poor health. Thus, to assess whether the uptake time could be reduced for single-photon emission computed tomography (SPECT) of the jawbone,...
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| Language: | English |
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BMC
2024-03-01
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| Series: | BMC Oral Health |
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| Online Access: | https://doi.org/10.1186/s12903-024-04067-2 |
| _version_ | 1827325968033775616 |
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| author | Hironobu Hata Satoshi Shimomura Kenji Imamachi Jun Sato Takuya Asaka Kenji Hirata Kyousuke Funayama Yoichi Mori Masashi Matsuzaka Toshikazu Nambu Yoshimasa Kitagawa |
| author_facet | Hironobu Hata Satoshi Shimomura Kenji Imamachi Jun Sato Takuya Asaka Kenji Hirata Kyousuke Funayama Yoichi Mori Masashi Matsuzaka Toshikazu Nambu Yoshimasa Kitagawa |
| author_sort | Hironobu Hata |
| collection | DOAJ |
| description | Abstract Background The long time required for bone uptake of radiopharmaceutical material after injection for bone scintigraphy is a burden for patients with poor health. Thus, to assess whether the uptake time could be reduced for single-photon emission computed tomography (SPECT) of the jawbone, this study evaluated differences in maximum standardized uptake values (SUVmax) within patients using SPECT imaging at 2 and 3 hours after radiopharmaceutical injection. Methods A total of 33 patients undergoing treatment or in post-treatment follow-up for medication-related osteonecrosis of the jaw, who visited our hospital between July 2020 and August 2021 and could receive SPECT twice on the same day, were enrolled in the study. Patients were injected with technetium-99 m hydroxymethylene diphosphonate (Tc-99 m HMDP) intravenously. The SUVmax for healthy parietal bones and jawbone lesions were calculated from the SPECT images using quantitative analysis software, and the SUVmax were compared between 2- and 3-hour uptake times. Results After exclusion, 30 patients were included in the study. In the 2-hour and 3-hour images, the median SUVmax of the parietal bones were 1.90 and 1.81, respectively, and those of the jawbone lesions were 9.25 and 9.39, respectively. The limits of agreement (LOA) ranged from − 0.33 to 0.25 in the parietal bones, and the %LOA ranged from − 9.8 to 17.3% in the jawbone lesions, showing high equivalence between the two uptake durations. The SUVmax showed no clinical differences between the 2- and 3-hour uptake durations for Tc-99 m HMDP SPECT of the jawbone. Conclusions The results of this study justify a 2–3-hour uptake window when performing quantitative SPECT of the jawbone. Therefore, the minimum uptake time can potentially be reduced to only 2 hours. |
| first_indexed | 2024-03-07T14:37:55Z |
| format | Article |
| id | doaj.art-8a411c5b75a443e2ac319f96c63c6fb1 |
| institution | Directory Open Access Journal |
| issn | 1472-6831 |
| language | English |
| last_indexed | 2024-03-07T14:37:55Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Oral Health |
| spelling | doaj.art-8a411c5b75a443e2ac319f96c63c6fb12024-03-05T20:33:12ZengBMCBMC Oral Health1472-68312024-03-0124111010.1186/s12903-024-04067-2Stability of standardized uptake values for quantitative bone SPECT for jawbone lesions: a single-center cross-sectional studyHironobu Hata0Satoshi Shimomura1Kenji Imamachi2Jun Sato3Takuya Asaka4Kenji Hirata5Kyousuke Funayama6Yoichi Mori7Masashi Matsuzaka8Toshikazu Nambu9Yoshimasa Kitagawa10Department of Dentistry and Oral Surgery, NHO Hokkaido Cancer CenterDepartment of Radiology, NHO Hokkaido Cancer CenterDepartment of Dentistry and Oral Surgery, NHO Hokkaido Cancer CenterOral Diagnosis and Medicine, Department of Oral Pathobiological Science, Faculty of Dental Medicine, Hokkaido UniversityOral Diagnosis and Medicine, Department of Oral Pathobiological Science, Faculty of Dental Medicine, Hokkaido UniversityDepartment of Diagnostic Imaging, Graduate School of Medicine, Hokkaido UniversityDepartment of Radiology, NHO Hokkaido Cancer CenterDepartment of Radiology, NHO Hokkaido Cancer CenterClinical Research Support Centre, Hirosaki University HospitalDepartment of Radiology, NHO Hokkaido Cancer CenterOral Diagnosis and Medicine, Department of Oral Pathobiological Science, Faculty of Dental Medicine, Hokkaido UniversityAbstract Background The long time required for bone uptake of radiopharmaceutical material after injection for bone scintigraphy is a burden for patients with poor health. Thus, to assess whether the uptake time could be reduced for single-photon emission computed tomography (SPECT) of the jawbone, this study evaluated differences in maximum standardized uptake values (SUVmax) within patients using SPECT imaging at 2 and 3 hours after radiopharmaceutical injection. Methods A total of 33 patients undergoing treatment or in post-treatment follow-up for medication-related osteonecrosis of the jaw, who visited our hospital between July 2020 and August 2021 and could receive SPECT twice on the same day, were enrolled in the study. Patients were injected with technetium-99 m hydroxymethylene diphosphonate (Tc-99 m HMDP) intravenously. The SUVmax for healthy parietal bones and jawbone lesions were calculated from the SPECT images using quantitative analysis software, and the SUVmax were compared between 2- and 3-hour uptake times. Results After exclusion, 30 patients were included in the study. In the 2-hour and 3-hour images, the median SUVmax of the parietal bones were 1.90 and 1.81, respectively, and those of the jawbone lesions were 9.25 and 9.39, respectively. The limits of agreement (LOA) ranged from − 0.33 to 0.25 in the parietal bones, and the %LOA ranged from − 9.8 to 17.3% in the jawbone lesions, showing high equivalence between the two uptake durations. The SUVmax showed no clinical differences between the 2- and 3-hour uptake durations for Tc-99 m HMDP SPECT of the jawbone. Conclusions The results of this study justify a 2–3-hour uptake window when performing quantitative SPECT of the jawbone. Therefore, the minimum uptake time can potentially be reduced to only 2 hours.https://doi.org/10.1186/s12903-024-04067-2SPECTQuantitative analysisMRONJUptake timeJawbone |
| spellingShingle | Hironobu Hata Satoshi Shimomura Kenji Imamachi Jun Sato Takuya Asaka Kenji Hirata Kyousuke Funayama Yoichi Mori Masashi Matsuzaka Toshikazu Nambu Yoshimasa Kitagawa Stability of standardized uptake values for quantitative bone SPECT for jawbone lesions: a single-center cross-sectional study BMC Oral Health SPECT Quantitative analysis MRONJ Uptake time Jawbone |
| title | Stability of standardized uptake values for quantitative bone SPECT for jawbone lesions: a single-center cross-sectional study |
| title_full | Stability of standardized uptake values for quantitative bone SPECT for jawbone lesions: a single-center cross-sectional study |
| title_fullStr | Stability of standardized uptake values for quantitative bone SPECT for jawbone lesions: a single-center cross-sectional study |
| title_full_unstemmed | Stability of standardized uptake values for quantitative bone SPECT for jawbone lesions: a single-center cross-sectional study |
| title_short | Stability of standardized uptake values for quantitative bone SPECT for jawbone lesions: a single-center cross-sectional study |
| title_sort | stability of standardized uptake values for quantitative bone spect for jawbone lesions a single center cross sectional study |
| topic | SPECT Quantitative analysis MRONJ Uptake time Jawbone |
| url | https://doi.org/10.1186/s12903-024-04067-2 |
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