Arid1a restrains Kras-dependent changes in acinar cell identity

Arid1a restrains Kras-dependent changes in acinar cell identity

Mutations in members of the SWI/SNF chromatin remodeling family are common events in cancer, but the mechanisms whereby disruption of SWI/SNF components alters tumorigenesis remain poorly understood. To model the effect of loss of function mutations in the SWI/SNF subunit Arid1a in pancreatic ductal...

Full description

Bibliographic Details
Main Authors: Geulah Livshits, Direna Alonso-Curbelo, John P Morris IV, Richard Koche, Michael Saborowski, John Erby Wilkinson, Scott W Lowe
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-07-01
Series:eLife
Subjects:
pancreas cancer
SWI/SNF
acinar cell
mouse model
RNAi
plasticity
Online Access:https://elifesciences.org/articles/35216

Similar Items

Similar Items