Rice bran phenolic extract supplementation ameliorates impaired lipid metabolism in high-fat-diet fed mice through AMPK activation in liver
Rice bran is a by-product of rice milling, which contains variety of nutrients, and has been reported to possess various activities. Here, we used high fat (HF) diet induced mice to investigate the effects of rice bran phenolic extracts (RBPE) on lipid metabolism. Sixteen-week intake of RBPE (200 mg...
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| Format: | Article |
| Language: | English |
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Elsevier
2020-10-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464620303558 |
| _version_ | 1818410530583347200 |
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| author | Ruifen Zhang Qin Ma Xin Tong Lei Liu Lihong Dong Fei Huang Yuanyuan Deng Xuchao Jia Jianwei Chi Mingwei Zhang |
| author_facet | Ruifen Zhang Qin Ma Xin Tong Lei Liu Lihong Dong Fei Huang Yuanyuan Deng Xuchao Jia Jianwei Chi Mingwei Zhang |
| author_sort | Ruifen Zhang |
| collection | DOAJ |
| description | Rice bran is a by-product of rice milling, which contains variety of nutrients, and has been reported to possess various activities. Here, we used high fat (HF) diet induced mice to investigate the effects of rice bran phenolic extracts (RBPE) on lipid metabolism. Sixteen-week intake of RBPE (200 mg/kg/d and 400 mg/kg/d) significantly improved the serum lipid profiles of HF diet-fed mice and ameliorated HF diet-induced liver steatosis. Further study showed that RBPE might regulate lipid metabolism through increasing the levels of serum adiponectin, and thereby promoting the activation of 5′ adenosine monophosphate-activated protein kinase α (AMPKα) in liver. Taken together, RBPE might regulate lipid metabolism through adiponectin-mediated AMPK activation and the subsequent reduction of lipid biosynthesis together with the increase of fatty acid oxidation in liver. These results provide us new evidence of the health benefits of rice bran. |
| first_indexed | 2024-12-14T10:16:59Z |
| format | Article |
| id | doaj.art-8a418757052c4f8daada0c4ecbc21363 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-14T10:16:59Z |
| publishDate | 2020-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-8a418757052c4f8daada0c4ecbc213632022-12-21T23:06:47ZengElsevierJournal of Functional Foods1756-46462020-10-0173104131Rice bran phenolic extract supplementation ameliorates impaired lipid metabolism in high-fat-diet fed mice through AMPK activation in liverRuifen Zhang0Qin Ma1Xin Tong2Lei Liu3Lihong Dong4Fei Huang5Yuanyuan Deng6Xuchao Jia7Jianwei Chi8Mingwei Zhang9Sericultural & Agri-Food Research Institute Guangdong Academy of Agricultural Sciences/Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs/Guangdong Key Laboratory of Agricultural Products Processing, Guangzhou 510610, ChinaSericultural & Agri-Food Research Institute Guangdong Academy of Agricultural Sciences/Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs/Guangdong Key Laboratory of Agricultural Products Processing, Guangzhou 510610, ChinaSericultural & Agri-Food Research Institute Guangdong Academy of Agricultural Sciences/Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs/Guangdong Key Laboratory of Agricultural Products Processing, Guangzhou 510610, ChinaSericultural & Agri-Food Research Institute Guangdong Academy of Agricultural Sciences/Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs/Guangdong Key Laboratory of Agricultural Products Processing, Guangzhou 510610, ChinaSericultural & Agri-Food Research Institute Guangdong Academy of Agricultural Sciences/Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs/Guangdong Key Laboratory of Agricultural Products Processing, Guangzhou 510610, ChinaSericultural & Agri-Food Research Institute Guangdong Academy of Agricultural Sciences/Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs/Guangdong Key Laboratory of Agricultural Products Processing, Guangzhou 510610, ChinaSericultural & Agri-Food Research Institute Guangdong Academy of Agricultural Sciences/Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs/Guangdong Key Laboratory of Agricultural Products Processing, Guangzhou 510610, ChinaSericultural & Agri-Food Research Institute Guangdong Academy of Agricultural Sciences/Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs/Guangdong Key Laboratory of Agricultural Products Processing, Guangzhou 510610, ChinaSericultural & Agri-Food Research Institute Guangdong Academy of Agricultural Sciences/Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs/Guangdong Key Laboratory of Agricultural Products Processing, Guangzhou 510610, ChinaCorresponding author.; Sericultural & Agri-Food Research Institute Guangdong Academy of Agricultural Sciences/Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs/Guangdong Key Laboratory of Agricultural Products Processing, Guangzhou 510610, ChinaRice bran is a by-product of rice milling, which contains variety of nutrients, and has been reported to possess various activities. Here, we used high fat (HF) diet induced mice to investigate the effects of rice bran phenolic extracts (RBPE) on lipid metabolism. Sixteen-week intake of RBPE (200 mg/kg/d and 400 mg/kg/d) significantly improved the serum lipid profiles of HF diet-fed mice and ameliorated HF diet-induced liver steatosis. Further study showed that RBPE might regulate lipid metabolism through increasing the levels of serum adiponectin, and thereby promoting the activation of 5′ adenosine monophosphate-activated protein kinase α (AMPKα) in liver. Taken together, RBPE might regulate lipid metabolism through adiponectin-mediated AMPK activation and the subsequent reduction of lipid biosynthesis together with the increase of fatty acid oxidation in liver. These results provide us new evidence of the health benefits of rice bran.http://www.sciencedirect.com/science/article/pii/S1756464620303558Rice branPhenolic compoundsLipid metabolismAMP-activated protein kinaseAdiponectin |
| spellingShingle | Ruifen Zhang Qin Ma Xin Tong Lei Liu Lihong Dong Fei Huang Yuanyuan Deng Xuchao Jia Jianwei Chi Mingwei Zhang Rice bran phenolic extract supplementation ameliorates impaired lipid metabolism in high-fat-diet fed mice through AMPK activation in liver Journal of Functional Foods Rice bran Phenolic compounds Lipid metabolism AMP-activated protein kinase Adiponectin |
| title | Rice bran phenolic extract supplementation ameliorates impaired lipid metabolism in high-fat-diet fed mice through AMPK activation in liver |
| title_full | Rice bran phenolic extract supplementation ameliorates impaired lipid metabolism in high-fat-diet fed mice through AMPK activation in liver |
| title_fullStr | Rice bran phenolic extract supplementation ameliorates impaired lipid metabolism in high-fat-diet fed mice through AMPK activation in liver |
| title_full_unstemmed | Rice bran phenolic extract supplementation ameliorates impaired lipid metabolism in high-fat-diet fed mice through AMPK activation in liver |
| title_short | Rice bran phenolic extract supplementation ameliorates impaired lipid metabolism in high-fat-diet fed mice through AMPK activation in liver |
| title_sort | rice bran phenolic extract supplementation ameliorates impaired lipid metabolism in high fat diet fed mice through ampk activation in liver |
| topic | Rice bran Phenolic compounds Lipid metabolism AMP-activated protein kinase Adiponectin |
| url | http://www.sciencedirect.com/science/article/pii/S1756464620303558 |
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