Dynamic mRNP Remodeling in Response to Internal and External Stimuli
Signal transduction and the regulation of gene expression are fundamental processes in every cell. RNA-binding proteins (RBPs) play a key role in the post-transcriptional modulation of gene expression in response to both internal and external stimuli. However, how signaling pathways regulate the ass...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/10/9/1310 |
| _version_ | 1797553932942180352 |
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| author | Kathi Zarnack Sureshkumar Balasubramanian Michael P. Gantier Vladislav Kunetsky Michael Kracht M. Lienhard Schmitz Katja Sträßer |
| author_facet | Kathi Zarnack Sureshkumar Balasubramanian Michael P. Gantier Vladislav Kunetsky Michael Kracht M. Lienhard Schmitz Katja Sträßer |
| author_sort | Kathi Zarnack |
| collection | DOAJ |
| description | Signal transduction and the regulation of gene expression are fundamental processes in every cell. RNA-binding proteins (RBPs) play a key role in the post-transcriptional modulation of gene expression in response to both internal and external stimuli. However, how signaling pathways regulate the assembly of RBPs with mRNAs remains largely unknown. Here, we summarize observations showing that the formation and composition of messenger ribonucleoprotein particles (mRNPs) is dynamically remodeled in space and time by specific signaling cascades and the resulting post-translational modifications. The integration of signaling events with gene expression is key to the rapid adaptation of cells to environmental changes and stress. Only a combined approach analyzing the signal transduction pathways and the changes in post-transcriptional gene expression they cause will unravel the mechanisms coordinating these important cellular processes. |
| first_indexed | 2024-03-10T16:24:33Z |
| format | Article |
| id | doaj.art-8a4369959d984890b0139c73c648f7ce |
| institution | Directory Open Access Journal |
| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T16:24:33Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj.art-8a4369959d984890b0139c73c648f7ce2023-11-20T13:23:43ZengMDPI AGBiomolecules2218-273X2020-09-01109131010.3390/biom10091310Dynamic mRNP Remodeling in Response to Internal and External StimuliKathi Zarnack0Sureshkumar Balasubramanian1Michael P. Gantier2Vladislav Kunetsky3Michael Kracht4M. Lienhard Schmitz5Katja Sträßer6Buchmann Institute for Molecular Life Sciences, Goethe University Frankfurt, 60438 Frankfurt a.M., GermanySchool of Biological Sciences, Monash University, Clayton, VIC 3800, AustraliaCentre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC 3168, AustraliaInstitute of Biochemistry, FB08, Justus Liebig University, 35392 Giessen, GermanyRudolf Buchheim Institute of Pharmacology, FB11, Justus Liebig University, 35392 Giessen, GermanyInstitute of Biochemistry, FB11, Justus Liebig University, 35392 Giessen, GermanyInstitute of Biochemistry, FB08, Justus Liebig University, 35392 Giessen, GermanySignal transduction and the regulation of gene expression are fundamental processes in every cell. RNA-binding proteins (RBPs) play a key role in the post-transcriptional modulation of gene expression in response to both internal and external stimuli. However, how signaling pathways regulate the assembly of RBPs with mRNAs remains largely unknown. Here, we summarize observations showing that the formation and composition of messenger ribonucleoprotein particles (mRNPs) is dynamically remodeled in space and time by specific signaling cascades and the resulting post-translational modifications. The integration of signaling events with gene expression is key to the rapid adaptation of cells to environmental changes and stress. Only a combined approach analyzing the signal transduction pathways and the changes in post-transcriptional gene expression they cause will unravel the mechanisms coordinating these important cellular processes.https://www.mdpi.com/2218-273X/10/9/1310signal transductionextracellular stimuliintracellular stimulistresspost-transcriptional gene regulationRNA-binding proteins (RBPs) |
| spellingShingle | Kathi Zarnack Sureshkumar Balasubramanian Michael P. Gantier Vladislav Kunetsky Michael Kracht M. Lienhard Schmitz Katja Sträßer Dynamic mRNP Remodeling in Response to Internal and External Stimuli Biomolecules signal transduction extracellular stimuli intracellular stimuli stress post-transcriptional gene regulation RNA-binding proteins (RBPs) |
| title | Dynamic mRNP Remodeling in Response to Internal and External Stimuli |
| title_full | Dynamic mRNP Remodeling in Response to Internal and External Stimuli |
| title_fullStr | Dynamic mRNP Remodeling in Response to Internal and External Stimuli |
| title_full_unstemmed | Dynamic mRNP Remodeling in Response to Internal and External Stimuli |
| title_short | Dynamic mRNP Remodeling in Response to Internal and External Stimuli |
| title_sort | dynamic mrnp remodeling in response to internal and external stimuli |
| topic | signal transduction extracellular stimuli intracellular stimuli stress post-transcriptional gene regulation RNA-binding proteins (RBPs) |
| url | https://www.mdpi.com/2218-273X/10/9/1310 |
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