CD36 and CD97 in Pancreatic Cancer versus Other Malignancies
Starting from the recent identification of CD36 and CD97 as a novel marker combination of fibroblast quiescence in lung during fibrosis, we aimed to survey the literature in search for facts about the separate (or concomitant) expression of clusters of differentiation CD36 and CD97 in either tumor-...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/21/16/5656 |
| _version_ | 1797559841890238464 |
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| author | Cristiana Tanase Ancuta-Augustina Gheorghisan-Galateanu Ionela Daniela Popescu Simona Mihai Elena Codrici Radu Albulescu Mihail Eugen Hinescu |
| author_facet | Cristiana Tanase Ancuta-Augustina Gheorghisan-Galateanu Ionela Daniela Popescu Simona Mihai Elena Codrici Radu Albulescu Mihail Eugen Hinescu |
| author_sort | Cristiana Tanase |
| collection | DOAJ |
| description | Starting from the recent identification of CD36 and CD97 as a novel marker combination of fibroblast quiescence in lung during fibrosis, we aimed to survey the literature in search for facts about the separate (or concomitant) expression of clusters of differentiation CD36 and CD97 in either tumor- or pancreatic-cancer-associated cells. Here, we provide an account of the current knowledge on the diversity of the cellular functions of CD36 and CD97 and explore their potential (common) contributions to key cellular events in oncogenesis or metastasis development. Emphasis is placed on quiescence as an underexplored mechanism and/or potential target in therapy. Furthermore, we discuss intricate signaling mechanisms and networks involving CD36 and CD97 that may regulate different subpopulations of tumor-associated cells, such as cancer-associated fibroblasts, adipocyte-associated fibroblasts, tumor-associated macrophages, or neutrophils, during aggressive pancreatic cancer. The coexistence of quiescence and activated states in cancer-associated cell subtypes during pancreatic cancer should be better documented, in different histological forms. Remodeling of the local microenvironment may also change the balance between growth and dormant state. Taking advantage of the reported data in different other tissue types, we explore the possibility to induce quiescence (similar to that observed in normal cells), as a therapeutic option to delay the currently observed clinical outcome. |
| first_indexed | 2024-03-10T17:51:00Z |
| format | Article |
| id | doaj.art-8a44b5cf84954b11954eff8bea97eb0d |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T17:51:00Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-8a44b5cf84954b11954eff8bea97eb0d2023-11-20T09:21:39ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-08-012116565610.3390/ijms21165656CD36 and CD97 in Pancreatic Cancer versus Other MalignanciesCristiana Tanase0Ancuta-Augustina Gheorghisan-Galateanu1Ionela Daniela Popescu2Simona Mihai3Elena Codrici4Radu Albulescu5Mihail Eugen Hinescu6Victor Babeș National Institute of Pathology, 99-101 Splaiul Independentei, 050096 Bucharest, RomaniaDepartment of Cellular and Molecular Biology and Histology, Carol Davila University of Medicine and Pharmacy, 8 Eroilor Sanitari Str., 050474 Bucharest, RomaniaVictor Babeș National Institute of Pathology, 99-101 Splaiul Independentei, 050096 Bucharest, RomaniaVictor Babeș National Institute of Pathology, 99-101 Splaiul Independentei, 050096 Bucharest, RomaniaVictor Babeș National Institute of Pathology, 99-101 Splaiul Independentei, 050096 Bucharest, RomaniaVictor Babeș National Institute of Pathology, 99-101 Splaiul Independentei, 050096 Bucharest, RomaniaVictor Babeș National Institute of Pathology, 99-101 Splaiul Independentei, 050096 Bucharest, RomaniaStarting from the recent identification of CD36 and CD97 as a novel marker combination of fibroblast quiescence in lung during fibrosis, we aimed to survey the literature in search for facts about the separate (or concomitant) expression of clusters of differentiation CD36 and CD97 in either tumor- or pancreatic-cancer-associated cells. Here, we provide an account of the current knowledge on the diversity of the cellular functions of CD36 and CD97 and explore their potential (common) contributions to key cellular events in oncogenesis or metastasis development. Emphasis is placed on quiescence as an underexplored mechanism and/or potential target in therapy. Furthermore, we discuss intricate signaling mechanisms and networks involving CD36 and CD97 that may regulate different subpopulations of tumor-associated cells, such as cancer-associated fibroblasts, adipocyte-associated fibroblasts, tumor-associated macrophages, or neutrophils, during aggressive pancreatic cancer. The coexistence of quiescence and activated states in cancer-associated cell subtypes during pancreatic cancer should be better documented, in different histological forms. Remodeling of the local microenvironment may also change the balance between growth and dormant state. Taking advantage of the reported data in different other tissue types, we explore the possibility to induce quiescence (similar to that observed in normal cells), as a therapeutic option to delay the currently observed clinical outcome.https://www.mdpi.com/1422-0067/21/16/5656pancreatic cancerCD36CD97cancer-associated fibroblastspancreatic ductal adenocarcinoma (PDAC)quiescence |
| spellingShingle | Cristiana Tanase Ancuta-Augustina Gheorghisan-Galateanu Ionela Daniela Popescu Simona Mihai Elena Codrici Radu Albulescu Mihail Eugen Hinescu CD36 and CD97 in Pancreatic Cancer versus Other Malignancies International Journal of Molecular Sciences pancreatic cancer CD36 CD97 cancer-associated fibroblasts pancreatic ductal adenocarcinoma (PDAC) quiescence |
| title | CD36 and CD97 in Pancreatic Cancer versus Other Malignancies |
| title_full | CD36 and CD97 in Pancreatic Cancer versus Other Malignancies |
| title_fullStr | CD36 and CD97 in Pancreatic Cancer versus Other Malignancies |
| title_full_unstemmed | CD36 and CD97 in Pancreatic Cancer versus Other Malignancies |
| title_short | CD36 and CD97 in Pancreatic Cancer versus Other Malignancies |
| title_sort | cd36 and cd97 in pancreatic cancer versus other malignancies |
| topic | pancreatic cancer CD36 CD97 cancer-associated fibroblasts pancreatic ductal adenocarcinoma (PDAC) quiescence |
| url | https://www.mdpi.com/1422-0067/21/16/5656 |
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