Optimized bilosome-based nanoparticles enhance cytotoxic and pro-apoptotic activity of costunolide in LS174T colon cancer cells

Optimized bilosome-based nanoparticles enhance cytotoxic and pro-apoptotic activity of costunolide in LS174T colon cancer cells

Costunolide (COST) is a sesquiterpene lactone that belongs to the germacranolide group, and occurs mainly in Saussurea lappa Clarke. Although COST inhibits the proliferation and metastasis of cancer cells and induces their apoptosis, it suffers poor water solubility and cellular permeability. Theref...

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Bibliographic Details
Main Authors: Abdulmohsin J. Alamoudi, Shaimaa M. Badr-Eldin, Osama A.A. Ahmed, Usama A. Fahmy, Serag Eldin I. Elbehairi, Mohammad Y. Alfaifi, Hani Z. Asfour, Gamal A. Mohamed, Sabrin R.M. Ibrahim, Ashraf B. Abdel-Naim, Hossam M. Abdallah
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Costunolide
Bilosomes
Apoptosis
Anti-proliferative activity
Colon cancer
Drug discovery
Online Access:http://www.sciencedirect.com/science/article/pii/S075333222301555X

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