Human Recombinant Alkaline Phosphatase (Ilofotase Alfa) Protects Against Kidney Ischemia-Reperfusion Injury in Mice and Rats Through Adenosine Receptors

Human Recombinant Alkaline Phosphatase (Ilofotase Alfa) Protects Against Kidney Ischemia-Reperfusion Injury in Mice and Rats Through Adenosine Receptors

Adenosine triphosphate (ATP) released from injured or dying cells is a potent pro-inflammatory “danger” signal. Alkaline phosphatase (AP), an endogenous enzyme that de-phosphorylates extracellular ATP, likely plays an anti-inflammatory role in immune responses. We hypothesized that ilofotase alfa, a...

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Bibliographic Details
Main Authors: Diane L. Rosin, J. Perry Hall, Shuqiu Zheng, Liping Huang, Silvia Campos-Bilderback, Ruben Sandoval, Andrea Bree, Kevin Beaumont, Emily Miller, Jennifer Larsen, Ghazal Hariri, Neelu Kaila, Iain M. Encarnacion, Jeremy D. Gale, Andrea van Elsas, Bruce A. Molitoris, Mark D. Okusa
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Medicine
Subjects:
acute kidney injury
adenosine
ATP
IRI
CD73
alkaline phosphatase
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2022.931293/full

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