Progress in the Development of Chitosan Based Insulin Delivery Systems: A Systematic Literature Review
Diabetes mellitus is a chronic disease that is considered a worldwide epidemic, and its control is a constant challenge for health systems. Since insulin had its first successful use, scientists have researched to improve the desired effects and reduce side-effects. Over the years, the challenge has...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-10-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/12/11/2499 |
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| author | Francivandi Coelho Barbosa Milena Costa da Silva Henrique Nunes da Silva Danyllo Albuquerque Allyson Antônio Ribeiro Gomes Suédina Maria de Lima Silva Marcus Vinícius Lia Fook |
| author_facet | Francivandi Coelho Barbosa Milena Costa da Silva Henrique Nunes da Silva Danyllo Albuquerque Allyson Antônio Ribeiro Gomes Suédina Maria de Lima Silva Marcus Vinícius Lia Fook |
| author_sort | Francivandi Coelho Barbosa |
| collection | DOAJ |
| description | Diabetes mellitus is a chronic disease that is considered a worldwide epidemic, and its control is a constant challenge for health systems. Since insulin had its first successful use, scientists have researched to improve the desired effects and reduce side-effects. Over the years, the challenge has been to increase adherence to treatment and improve the quality of life for diabetics by developing an insulin delivery system. This systematic review (SR) analyses experimental articles from 1998 to 2018 related to the development of the chitosan/insulin delivery system (CIDS). Automated support: Start tool was used to perform part of these activities. The search terms “insulin”, “delivery or release system”, and “chitosan” were used to retrieve articles in PubMed, Science Direct, Engineering Village, and HubMed. A total of 55 articles were selected. The overview, phase, model, way of administration, and the efficiency of CIDS were analyzed. According to SR results, most of the articles were published from 2010 onwards, representing 72.7% of the selected papers, and research groups from China publicized 23.6% of the selected articles. According to the SR, 51% of the studies were carried out in vivo and 45% in vitro. Most of the systems were nanoparticle based (54.8%), and oral administration was proposed by 60.0% of the selected articles. Only 36.4% performed loaded capacity and encapsulation efficiency assays, and 24 h (16.4%), 12 h (12.7%), and 6 h (11.0%) were the most frequent insulin release times. Chitosan’s intrinsic characteristics, which include biodegradability, biocompatibility, adhesiveness, the ability to open epithelial tight junctions to allow an increase in the paracellular transport of macromolecular drugs, such as insulin, and the fact that it does not result in allergic reactions in the human body after implantation, injection, topical application or ingestion, have contributed to the increase in research of CIDS over the years. However, the number of studies is still limited and the use of an alternative form of insulin administration is not yet possible. Thus, more studies in this area, aiming for the development of an insulin delivery system that can promote more adherence to the treatment and patient comfort, are required. |
| first_indexed | 2024-03-10T15:17:56Z |
| format | Article |
| id | doaj.art-8a49f140ada34eaa8363104c4408dc16 |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-10T15:17:56Z |
| publishDate | 2020-10-01 |
| publisher | MDPI AG |
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| series | Polymers |
| spelling | doaj.art-8a49f140ada34eaa8363104c4408dc162023-11-20T18:46:53ZengMDPI AGPolymers2073-43602020-10-011211249910.3390/polym12112499Progress in the Development of Chitosan Based Insulin Delivery Systems: A Systematic Literature ReviewFrancivandi Coelho Barbosa0Milena Costa da Silva1Henrique Nunes da Silva2Danyllo Albuquerque3Allyson Antônio Ribeiro Gomes4Suédina Maria de Lima Silva5Marcus Vinícius Lia Fook6Department of Materials Engineering, Postgraduate Program in Materials Science and Engineering, Federal University of Campina Grande, Campina Grande PB 58429-900, BrazilDepartment of Materials Engineering, Postgraduate Program in Materials Science and Engineering, Federal University of Campina Grande, Campina Grande PB 58429-900, BrazilDepartment of Materials Engineering, Postgraduate Program in Materials Science and Engineering, Federal University of Campina Grande, Campina Grande PB 58429-900, BrazilElectrical Engineering and Informatics Centre, Postgraduate Program in Computer Science, Federal University of Campina Grande, Campina Grande PB 58429-900, BrazilDepartment of Materials Engineering, Postgraduate Program in Materials Science and Engineering, Federal University of Campina Grande, Campina Grande PB 58429-900, BrazilDepartment of Materials Engineering, Federal University of Campina Grande, Campina Grande, PB 58429-900, BrazilDepartment of Materials Engineering, Federal University of Campina Grande, Campina Grande, PB 58429-900, BrazilDiabetes mellitus is a chronic disease that is considered a worldwide epidemic, and its control is a constant challenge for health systems. Since insulin had its first successful use, scientists have researched to improve the desired effects and reduce side-effects. Over the years, the challenge has been to increase adherence to treatment and improve the quality of life for diabetics by developing an insulin delivery system. This systematic review (SR) analyses experimental articles from 1998 to 2018 related to the development of the chitosan/insulin delivery system (CIDS). Automated support: Start tool was used to perform part of these activities. The search terms “insulin”, “delivery or release system”, and “chitosan” were used to retrieve articles in PubMed, Science Direct, Engineering Village, and HubMed. A total of 55 articles were selected. The overview, phase, model, way of administration, and the efficiency of CIDS were analyzed. According to SR results, most of the articles were published from 2010 onwards, representing 72.7% of the selected papers, and research groups from China publicized 23.6% of the selected articles. According to the SR, 51% of the studies were carried out in vivo and 45% in vitro. Most of the systems were nanoparticle based (54.8%), and oral administration was proposed by 60.0% of the selected articles. Only 36.4% performed loaded capacity and encapsulation efficiency assays, and 24 h (16.4%), 12 h (12.7%), and 6 h (11.0%) were the most frequent insulin release times. Chitosan’s intrinsic characteristics, which include biodegradability, biocompatibility, adhesiveness, the ability to open epithelial tight junctions to allow an increase in the paracellular transport of macromolecular drugs, such as insulin, and the fact that it does not result in allergic reactions in the human body after implantation, injection, topical application or ingestion, have contributed to the increase in research of CIDS over the years. However, the number of studies is still limited and the use of an alternative form of insulin administration is not yet possible. Thus, more studies in this area, aiming for the development of an insulin delivery system that can promote more adherence to the treatment and patient comfort, are required.https://www.mdpi.com/2073-4360/12/11/2499delivery systemrelease systeminsulinchitosansystematic review |
| spellingShingle | Francivandi Coelho Barbosa Milena Costa da Silva Henrique Nunes da Silva Danyllo Albuquerque Allyson Antônio Ribeiro Gomes Suédina Maria de Lima Silva Marcus Vinícius Lia Fook Progress in the Development of Chitosan Based Insulin Delivery Systems: A Systematic Literature Review Polymers delivery system release system insulin chitosan systematic review |
| title | Progress in the Development of Chitosan Based Insulin Delivery Systems: A Systematic Literature Review |
| title_full | Progress in the Development of Chitosan Based Insulin Delivery Systems: A Systematic Literature Review |
| title_fullStr | Progress in the Development of Chitosan Based Insulin Delivery Systems: A Systematic Literature Review |
| title_full_unstemmed | Progress in the Development of Chitosan Based Insulin Delivery Systems: A Systematic Literature Review |
| title_short | Progress in the Development of Chitosan Based Insulin Delivery Systems: A Systematic Literature Review |
| title_sort | progress in the development of chitosan based insulin delivery systems a systematic literature review |
| topic | delivery system release system insulin chitosan systematic review |
| url | https://www.mdpi.com/2073-4360/12/11/2499 |
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