Proteases of Malaria Parasites: New Targets for Chemotherapy
The increasing resistance of malaria parasites to antimalarial drugs is a major contributor to the reemergence of the disease as a major public health problem and its spread in new locations and populations. Among potential targets for new modes of chemotherapy are malarial proteases, which appear t...
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Centers for Disease Control and Prevention
1998-03-01
|
| Series: | Emerging Infectious Diseases |
| Subjects: | |
| Online Access: | https://wwwnc.cdc.gov/eid/article/4/1/98-0107_article |
| _version_ | 1818910918238535680 |
|---|---|
| author | Philip J. Rosenthal |
| author_facet | Philip J. Rosenthal |
| author_sort | Philip J. Rosenthal |
| collection | DOAJ |
| description | The increasing resistance of malaria parasites to antimalarial drugs is a major contributor to the reemergence of the disease as a major public health problem and its spread in new locations and populations. Among potential targets for new modes of chemotherapy are malarial proteases, which appear to mediate processes within the erythrocytic malarial life cycle, including the rupture and invasion of infected erythrocytes and the degradation of hemoglobin by trophozoites. Cysteine and aspartic protease inhibitors are now under study as potential antimalarials. Lead compounds have blocked in vitro parasite development at nanomolar concentrations and cured malaria-infected mice. This review discusses available antimalarial agents and summarizes experimental results that support development of protease inhibitors as antimalarial drugs. |
| first_indexed | 2024-12-19T22:50:26Z |
| format | Article |
| id | doaj.art-8a4a69bbd1c945128232a2247fe0b5ce |
| institution | Directory Open Access Journal |
| issn | 1080-6040 1080-6059 |
| language | English |
| last_indexed | 2024-12-19T22:50:26Z |
| publishDate | 1998-03-01 |
| publisher | Centers for Disease Control and Prevention |
| record_format | Article |
| series | Emerging Infectious Diseases |
| spelling | doaj.art-8a4a69bbd1c945128232a2247fe0b5ce2022-12-21T20:02:50ZengCenters for Disease Control and PreventionEmerging Infectious Diseases1080-60401080-60591998-03-0141495710.3201/eid0401.980107Proteases of Malaria Parasites: New Targets for ChemotherapyPhilip J. RosenthalThe increasing resistance of malaria parasites to antimalarial drugs is a major contributor to the reemergence of the disease as a major public health problem and its spread in new locations and populations. Among potential targets for new modes of chemotherapy are malarial proteases, which appear to mediate processes within the erythrocytic malarial life cycle, including the rupture and invasion of infected erythrocytes and the degradation of hemoglobin by trophozoites. Cysteine and aspartic protease inhibitors are now under study as potential antimalarials. Lead compounds have blocked in vitro parasite development at nanomolar concentrations and cured malaria-infected mice. This review discusses available antimalarial agents and summarizes experimental results that support development of protease inhibitors as antimalarial drugs.https://wwwnc.cdc.gov/eid/article/4/1/98-0107_articleUnited States |
| spellingShingle | Philip J. Rosenthal Proteases of Malaria Parasites: New Targets for Chemotherapy Emerging Infectious Diseases United States |
| title | Proteases of Malaria Parasites: New Targets for Chemotherapy |
| title_full | Proteases of Malaria Parasites: New Targets for Chemotherapy |
| title_fullStr | Proteases of Malaria Parasites: New Targets for Chemotherapy |
| title_full_unstemmed | Proteases of Malaria Parasites: New Targets for Chemotherapy |
| title_short | Proteases of Malaria Parasites: New Targets for Chemotherapy |
| title_sort | proteases of malaria parasites new targets for chemotherapy |
| topic | United States |
| url | https://wwwnc.cdc.gov/eid/article/4/1/98-0107_article |
| work_keys_str_mv | AT philipjrosenthal proteasesofmalariaparasitesnewtargetsforchemotherapy |