Association between Chronic Kidney Disease and Chronic Rhinosinusitis: A Longitudinal Follow-Up Study Using a National Health Screening Cohort
Chronic kidney disease (CKD) is a leading cause of global mortality. While recent reports suggest potential connections between CKD and chronic rhinosinusitis (CRS), further research is needed to elucidate the direct association between CKD and CRS. This study investigated the association between CK...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/14/3/268 |
| _version_ | 1797240354671427584 |
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| author | Heejin Kim Tae Jun Kim Mi Jung Kwon Jee Hye Wee Sung Kwang Hong Hyo Geun Choi Joong Seob Lee |
| author_facet | Heejin Kim Tae Jun Kim Mi Jung Kwon Jee Hye Wee Sung Kwang Hong Hyo Geun Choi Joong Seob Lee |
| author_sort | Heejin Kim |
| collection | DOAJ |
| description | Chronic kidney disease (CKD) is a leading cause of global mortality. While recent reports suggest potential connections between CKD and chronic rhinosinusitis (CRS), further research is needed to elucidate the direct association between CKD and CRS. This study investigated the association between CKD and CRS using data from the Korean National Health Insurance Service Health Screening Cohort. Participants were recruited according to medical claim codes, and individuals with CKD were matched in a 1:4 ratio with the control group. Covariates, such as demographics, health-related data, and medical history were used. The incidence rates and hazard ratio of CRS were analyzed. A further analysis was performed based on the presence of nasal polyps. Among the 514,866 participants, 16,644 patients with CKD and 66,576 matched controls were included in the analysis. The CKD group demonstrated a higher incidence of CRS than the controls: 18.30 versus 13.10 per 10,000 person-years. The CKD group demonstrated a higher risk of CRS than the control group (1.28 adjusted hazard ratio). In additional analyses, the CKD group did not exhibit a statistically significant correlation for the development of CRS with nasal polyps. This study suggests that CKD is associated with an increased risk for CRS. |
| first_indexed | 2024-04-24T18:06:06Z |
| format | Article |
| id | doaj.art-8a4addc994224346977ef42e2abd010a |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-04-24T18:06:06Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-8a4addc994224346977ef42e2abd010a2024-03-27T13:50:07ZengMDPI AGJournal of Personalized Medicine2075-44262024-02-0114326810.3390/jpm14030268Association between Chronic Kidney Disease and Chronic Rhinosinusitis: A Longitudinal Follow-Up Study Using a National Health Screening CohortHeejin Kim0Tae Jun Kim1Mi Jung Kwon2Jee Hye Wee3Sung Kwang Hong4Hyo Geun Choi5Joong Seob Lee6Department of Otorhinolaryngology-Head & Neck Surgery, Hallym University Sacred Heart Hospital, Anyang 14068, Republic of KoreaDepartment of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Republic of KoreaDepartment of Pathology, Hallym University Sacred Heart Hospital, Anyang 14068, Republic of KoreaDepartment of Otorhinolaryngology-Head & Neck Surgery, Hallym University Sacred Heart Hospital, Anyang 14068, Republic of KoreaDepartment of Otorhinolaryngology-Head & Neck Surgery, Hallym University Sacred Heart Hospital, Anyang 14068, Republic of KoreaSuseo Seoul ENT Clinics, Seoul 06349, Republic of KoreaDepartment of Otorhinolaryngology-Head & Neck Surgery, Hallym University Sacred Heart Hospital, Anyang 14068, Republic of KoreaChronic kidney disease (CKD) is a leading cause of global mortality. While recent reports suggest potential connections between CKD and chronic rhinosinusitis (CRS), further research is needed to elucidate the direct association between CKD and CRS. This study investigated the association between CKD and CRS using data from the Korean National Health Insurance Service Health Screening Cohort. Participants were recruited according to medical claim codes, and individuals with CKD were matched in a 1:4 ratio with the control group. Covariates, such as demographics, health-related data, and medical history were used. The incidence rates and hazard ratio of CRS were analyzed. A further analysis was performed based on the presence of nasal polyps. Among the 514,866 participants, 16,644 patients with CKD and 66,576 matched controls were included in the analysis. The CKD group demonstrated a higher incidence of CRS than the controls: 18.30 versus 13.10 per 10,000 person-years. The CKD group demonstrated a higher risk of CRS than the control group (1.28 adjusted hazard ratio). In additional analyses, the CKD group did not exhibit a statistically significant correlation for the development of CRS with nasal polyps. This study suggests that CKD is associated with an increased risk for CRS.https://www.mdpi.com/2075-4426/14/3/268chronic rhinosinusitischronic kidney diseasecohort study |
| spellingShingle | Heejin Kim Tae Jun Kim Mi Jung Kwon Jee Hye Wee Sung Kwang Hong Hyo Geun Choi Joong Seob Lee Association between Chronic Kidney Disease and Chronic Rhinosinusitis: A Longitudinal Follow-Up Study Using a National Health Screening Cohort Journal of Personalized Medicine chronic rhinosinusitis chronic kidney disease cohort study |
| title | Association between Chronic Kidney Disease and Chronic Rhinosinusitis: A Longitudinal Follow-Up Study Using a National Health Screening Cohort |
| title_full | Association between Chronic Kidney Disease and Chronic Rhinosinusitis: A Longitudinal Follow-Up Study Using a National Health Screening Cohort |
| title_fullStr | Association between Chronic Kidney Disease and Chronic Rhinosinusitis: A Longitudinal Follow-Up Study Using a National Health Screening Cohort |
| title_full_unstemmed | Association between Chronic Kidney Disease and Chronic Rhinosinusitis: A Longitudinal Follow-Up Study Using a National Health Screening Cohort |
| title_short | Association between Chronic Kidney Disease and Chronic Rhinosinusitis: A Longitudinal Follow-Up Study Using a National Health Screening Cohort |
| title_sort | association between chronic kidney disease and chronic rhinosinusitis a longitudinal follow up study using a national health screening cohort |
| topic | chronic rhinosinusitis chronic kidney disease cohort study |
| url | https://www.mdpi.com/2075-4426/14/3/268 |
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