Comparison of Treatment Result Between Anticoagulation Alone and Catheter-Directed Thrombolysis Plus Anticoagulation in Acute Lower Extremity Deep Vein Thrombosis
Purpose: Deep vein thrombosis (DVT) is the third most common cause of cardiovascular morbidity and mortality. Anticoagulation has been the primary treatment modality for acute DVT. However, catheter-directed thrombolysis (CDT) has recently become widely accepted as an additional therapy to anticoagu...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Medrang
2019-03-01
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| Series: | Vascular Specialist International |
| Subjects: | |
| Online Access: | http://www.vsijournal.org/journal/view.html?doi=10.5758/vsi.2019.35.1.28 |
| _version_ | 1811275207622524928 |
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| author | Young Jin Choi Dong Hyun Kim Dong il Kim Hyun-Yul Kim Sang Su Lee Hyuk Jae Jung |
| author_facet | Young Jin Choi Dong Hyun Kim Dong il Kim Hyun-Yul Kim Sang Su Lee Hyuk Jae Jung |
| author_sort | Young Jin Choi |
| collection | DOAJ |
| description | Purpose: Deep vein thrombosis (DVT) is the third most common cause of cardiovascular morbidity and mortality. Anticoagulation has been the primary treatment modality for acute DVT. However, catheter-directed thrombolysis (CDT) has recently become widely accepted as an additional therapy to anticoagulation. We assessed comparative outcomes in patients with acute DVT who underwent anticoagulation therapy alone (ACA) group and those treated with CDT group.
Materials and Methods: We retrospectively reviewed medical records of 149 patients with DVT from January 2011 to December 2015. We compared patients who received ACA group (n=120) and those who received CDT plus anticoagulation (CDT group, n=29). We analyzed the prevalence of lesions, thrombus removal rate in each lesion, and recurrence-free rate between the two groups.
Results: We found thrombus involvement in a total of 281 lesions in the ACA group and 85 lesions in the CDT group. For the distribution of lesions in each group, those in the femoral vein accounted for 34.2% of all lesions and those in the popliteal vein accounted for 31.7%. During follow-up, the overall thrombus removal rate was 91.1% in the ACA group and 87.0% in the CDT group (P=0.273). The recurrence-free rate was higher in the CDT group in a log-rank test; however, there was no statistically significant difference between the two groups (P=0.594).
Conclusion: According to our results, there was no significant difference in thrombus removal and recurrence-free rates between the CDT and ACA groups. ACA still has an important role in the treatment of DVT. |
| first_indexed | 2024-04-12T23:33:54Z |
| format | Article |
| id | doaj.art-8a4aee2d69734b5e93295715ba91b93a |
| institution | Directory Open Access Journal |
| issn | 2288-7970 |
| language | English |
| last_indexed | 2024-04-12T23:33:54Z |
| publishDate | 2019-03-01 |
| publisher | Medrang |
| record_format | Article |
| series | Vascular Specialist International |
| spelling | doaj.art-8a4aee2d69734b5e93295715ba91b93a2022-12-22T03:12:12ZengMedrangVascular Specialist International2288-79702019-03-01351283310.5758/vsi.2019.35.1.28vsi.2019.35.1.28Comparison of Treatment Result Between Anticoagulation Alone and Catheter-Directed Thrombolysis Plus Anticoagulation in Acute Lower Extremity Deep Vein ThrombosisYoung Jin Choi0Dong Hyun Kim1Dong il Kim2Hyun-Yul Kim3Sang Su Lee4Hyuk Jae Jung5Endovascular and Vascular Division, Department of Surgery, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, KoreaEndovascular and Vascular Division, Department of Surgery, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, KoreaEndovascular and Vascular Division, Department of Surgery, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, KoreaEndovascular and Vascular Division, Department of Surgery, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, KoreaEndovascular and Vascular Division, Department of Surgery, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, KoreaEndovascular and Vascular Division, Department of Surgery, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, KoreaPurpose: Deep vein thrombosis (DVT) is the third most common cause of cardiovascular morbidity and mortality. Anticoagulation has been the primary treatment modality for acute DVT. However, catheter-directed thrombolysis (CDT) has recently become widely accepted as an additional therapy to anticoagulation. We assessed comparative outcomes in patients with acute DVT who underwent anticoagulation therapy alone (ACA) group and those treated with CDT group. Materials and Methods: We retrospectively reviewed medical records of 149 patients with DVT from January 2011 to December 2015. We compared patients who received ACA group (n=120) and those who received CDT plus anticoagulation (CDT group, n=29). We analyzed the prevalence of lesions, thrombus removal rate in each lesion, and recurrence-free rate between the two groups. Results: We found thrombus involvement in a total of 281 lesions in the ACA group and 85 lesions in the CDT group. For the distribution of lesions in each group, those in the femoral vein accounted for 34.2% of all lesions and those in the popliteal vein accounted for 31.7%. During follow-up, the overall thrombus removal rate was 91.1% in the ACA group and 87.0% in the CDT group (P=0.273). The recurrence-free rate was higher in the CDT group in a log-rank test; however, there was no statistically significant difference between the two groups (P=0.594). Conclusion: According to our results, there was no significant difference in thrombus removal and recurrence-free rates between the CDT and ACA groups. ACA still has an important role in the treatment of DVT.http://www.vsijournal.org/journal/view.html?doi=10.5758/vsi.2019.35.1.28Venous thrombosisAnticoagulantsThrombolytic therapy |
| spellingShingle | Young Jin Choi Dong Hyun Kim Dong il Kim Hyun-Yul Kim Sang Su Lee Hyuk Jae Jung Comparison of Treatment Result Between Anticoagulation Alone and Catheter-Directed Thrombolysis Plus Anticoagulation in Acute Lower Extremity Deep Vein Thrombosis Vascular Specialist International Venous thrombosis Anticoagulants Thrombolytic therapy |
| title | Comparison of Treatment Result Between Anticoagulation Alone and Catheter-Directed Thrombolysis Plus Anticoagulation in Acute Lower Extremity Deep Vein Thrombosis |
| title_full | Comparison of Treatment Result Between Anticoagulation Alone and Catheter-Directed Thrombolysis Plus Anticoagulation in Acute Lower Extremity Deep Vein Thrombosis |
| title_fullStr | Comparison of Treatment Result Between Anticoagulation Alone and Catheter-Directed Thrombolysis Plus Anticoagulation in Acute Lower Extremity Deep Vein Thrombosis |
| title_full_unstemmed | Comparison of Treatment Result Between Anticoagulation Alone and Catheter-Directed Thrombolysis Plus Anticoagulation in Acute Lower Extremity Deep Vein Thrombosis |
| title_short | Comparison of Treatment Result Between Anticoagulation Alone and Catheter-Directed Thrombolysis Plus Anticoagulation in Acute Lower Extremity Deep Vein Thrombosis |
| title_sort | comparison of treatment result between anticoagulation alone and catheter directed thrombolysis plus anticoagulation in acute lower extremity deep vein thrombosis |
| topic | Venous thrombosis Anticoagulants Thrombolytic therapy |
| url | http://www.vsijournal.org/journal/view.html?doi=10.5758/vsi.2019.35.1.28 |
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