Losartan may prevent the elevation of plasma glucose, corticosterone and catecholamine levels induced by chronic stress
Introduction Stress is a stimulus that activates the hypothalamic pituitary adrenal (HPA) axis and sympathetic nervous system (SNS). Increased activity of the SNS causes to increment or impairment in blood pressure, heart rate, body temperature and plasma glucose and adrenocorticotrophic hormone (AC...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publications
2004-06-01
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| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | https://doi.org/10.3317/jraas.2004.017 |
| _version_ | 1797283737568804864 |
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| author | Yağiz Üresin Bahar Erbas Mehmet Özek Elif Özkök Ali Osman Gürol |
| author_facet | Yağiz Üresin Bahar Erbas Mehmet Özek Elif Özkök Ali Osman Gürol |
| author_sort | Yağiz Üresin |
| collection | DOAJ |
| description | Introduction Stress is a stimulus that activates the hypothalamic pituitary adrenal (HPA) axis and sympathetic nervous system (SNS). Increased activity of the SNS causes to increment or impairment in blood pressure, heart rate, body temperature and plasma glucose and adrenocorticotrophic hormone (ACTH) levels. Angiotensin II (Ang II), which is a product of the renin-angiotensin system (RAS), is an important factor affecting the activity of the SNS and responses to stress. We suggest that the blockade of Ang II may be worthwhile in the prevention and treatment of diabetes mellitus and cardiovascular diseases affected by stress. Therefore, we investigated the effects of immobilisation stress on blood glucose, norepinephrine (NE), epinephrine (E) and corticosterone levels and the effects of an Ang II receptor antagonist, losartan, on these parameters. Materials and methods The rats were kept in small cylindrical cages for 60 min/day for 10 consecutive days to perform chronic immobilisation stress. Losartan (10 mg/kg) was given daily by gavage to Losartan (L) and Losartan + Chronic Stress (L+CS) groups. Control (C) and Chronic Stress (CS) P groups received an equal volume of saline daily by gavage for 10 days. After the last stress regimen, blood samples were collected for plasma glucose, NE, E and corticosteroid measurements. Results Plasma glucose, NE, E and corticosterone levels in the CS Group increased significantly compared with the C group. In Group L+CS, the plasma glucose, NE, E and corticosterone levels decreased significantly vs. Group CS. In Group L there was no significant difference vs. Group C. Conclusion It can be speculated that chronic blockade of RAS may decrease the excess sympathetic responses to stress in cardiovascular diseases and prevent the likely development of Type II diabetes mellitus. |
| first_indexed | 2024-03-07T17:36:07Z |
| format | Article |
| id | doaj.art-8a4d0d813581420aab21ba4ad8f5499c |
| institution | Directory Open Access Journal |
| issn | 1470-3203 |
| language | English |
| last_indexed | 2024-03-07T17:36:07Z |
| publishDate | 2004-06-01 |
| publisher | SAGE Publications |
| record_format | Article |
| series | Journal of the Renin-Angiotensin-Aldosterone System |
| spelling | doaj.art-8a4d0d813581420aab21ba4ad8f5499c2024-03-02T16:51:15ZengSAGE PublicationsJournal of the Renin-Angiotensin-Aldosterone System1470-32032004-06-01510.3317/jraas.2004.017Losartan may prevent the elevation of plasma glucose, corticosterone and catecholamine levels induced by chronic stressYağiz ÜresinBahar ErbasMehmet ÖzekElif ÖzkökAli Osman GürolIntroduction Stress is a stimulus that activates the hypothalamic pituitary adrenal (HPA) axis and sympathetic nervous system (SNS). Increased activity of the SNS causes to increment or impairment in blood pressure, heart rate, body temperature and plasma glucose and adrenocorticotrophic hormone (ACTH) levels. Angiotensin II (Ang II), which is a product of the renin-angiotensin system (RAS), is an important factor affecting the activity of the SNS and responses to stress. We suggest that the blockade of Ang II may be worthwhile in the prevention and treatment of diabetes mellitus and cardiovascular diseases affected by stress. Therefore, we investigated the effects of immobilisation stress on blood glucose, norepinephrine (NE), epinephrine (E) and corticosterone levels and the effects of an Ang II receptor antagonist, losartan, on these parameters. Materials and methods The rats were kept in small cylindrical cages for 60 min/day for 10 consecutive days to perform chronic immobilisation stress. Losartan (10 mg/kg) was given daily by gavage to Losartan (L) and Losartan + Chronic Stress (L+CS) groups. Control (C) and Chronic Stress (CS) P groups received an equal volume of saline daily by gavage for 10 days. After the last stress regimen, blood samples were collected for plasma glucose, NE, E and corticosteroid measurements. Results Plasma glucose, NE, E and corticosterone levels in the CS Group increased significantly compared with the C group. In Group L+CS, the plasma glucose, NE, E and corticosterone levels decreased significantly vs. Group CS. In Group L there was no significant difference vs. Group C. Conclusion It can be speculated that chronic blockade of RAS may decrease the excess sympathetic responses to stress in cardiovascular diseases and prevent the likely development of Type II diabetes mellitus.https://doi.org/10.3317/jraas.2004.017 |
| spellingShingle | Yağiz Üresin Bahar Erbas Mehmet Özek Elif Özkök Ali Osman Gürol Losartan may prevent the elevation of plasma glucose, corticosterone and catecholamine levels induced by chronic stress Journal of the Renin-Angiotensin-Aldosterone System |
| title | Losartan may prevent the elevation of plasma glucose, corticosterone and catecholamine levels induced by chronic stress |
| title_full | Losartan may prevent the elevation of plasma glucose, corticosterone and catecholamine levels induced by chronic stress |
| title_fullStr | Losartan may prevent the elevation of plasma glucose, corticosterone and catecholamine levels induced by chronic stress |
| title_full_unstemmed | Losartan may prevent the elevation of plasma glucose, corticosterone and catecholamine levels induced by chronic stress |
| title_short | Losartan may prevent the elevation of plasma glucose, corticosterone and catecholamine levels induced by chronic stress |
| title_sort | losartan may prevent the elevation of plasma glucose corticosterone and catecholamine levels induced by chronic stress |
| url | https://doi.org/10.3317/jraas.2004.017 |
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