Paclitaxel-incorporated nanoparticles improve functional recovery after spinal cord injury
As a worldwide medical problem, spinal cord injury has no clear and effective treatment to improve its prognosis. Hence, new treatment strategies for spinal cord injury with good therapeutic efficacy have been actively pursued. As a new drug loading system, acetal dextran nanoparticles (SAD) have go...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.957433/full |
| _version_ | 1798040676522262528 |
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| author | Xinzhu Zhang Xinzhu Zhang Wu Xiong Wu Xiong Guang Kong Guang Kong Guang Kong Yushan Zhen Qiang Zeng Siming Wang Siming Wang Sheng Chen Jun Gu Cong Li Cong Li Kaijin Guo |
| author_facet | Xinzhu Zhang Xinzhu Zhang Wu Xiong Wu Xiong Guang Kong Guang Kong Guang Kong Yushan Zhen Qiang Zeng Siming Wang Siming Wang Sheng Chen Jun Gu Cong Li Cong Li Kaijin Guo |
| author_sort | Xinzhu Zhang |
| collection | DOAJ |
| description | As a worldwide medical problem, spinal cord injury has no clear and effective treatment to improve its prognosis. Hence, new treatment strategies for spinal cord injury with good therapeutic efficacy have been actively pursued. As a new drug loading system, acetal dextran nanoparticles (SAD) have good biocompatibility and biodegradability. Therefore, we designed spermine-functionalized acetal-dextran (SAD) nanoparticles and encapsulated paclitaxel (PCL) into them. This design can ensure the sustained release of paclitaxel in the injured area for 4 days and promote the extension of nerve processes in vitro. In our experiment, we found that paclitaxel-loaded SAD nanoparticles (PCL@SAD) decreased the level of chondroitin sulfate proteoglycan in the rat spinal cord injury model, which reduced the scar repair of the injured site and changed the inhibitory environment after spinal cord injury. This reveals that PCL@SAD can effectively protect the injured spinal cord and ultimately improve the functional recovery of the injured spinal cord. One single injection of PCL@SAD shows better therapeutic effect than that of PCL. This study opens an exciting perspective toward the application of neuroprotective PCL@SAD for the treatment of severe neurological diseases. |
| first_indexed | 2024-04-11T22:10:52Z |
| format | Article |
| id | doaj.art-8a4d8fa6caeb4eed88b814ddd9e2ded3 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-11T22:10:52Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-8a4d8fa6caeb4eed88b814ddd9e2ded32022-12-22T04:00:34ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-08-011310.3389/fphar.2022.957433957433Paclitaxel-incorporated nanoparticles improve functional recovery after spinal cord injuryXinzhu Zhang0Xinzhu Zhang1Wu Xiong2Wu Xiong3Guang Kong4Guang Kong5Guang Kong6Yushan Zhen7Qiang Zeng8Siming Wang9Siming Wang10Sheng Chen11Jun Gu12Cong Li13Cong Li14Kaijin Guo15Nanjing Medical University, Nanjing, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Xuzhou Medical University, Xuzhou, ChinaNanjing Medical University, Nanjing, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaNanjing Medical University, Nanjing, ChinaGusu School, Nanjing Medical University, Suzhou, ChinaDepartment of Orthopedics, The Affiliated Jiangsu Shengze Hospital of Nanjing Medical University, Suzhou, ChinaMedical College of Jiangsu University, Zhenjiang, ChinaNanjing Medical University, Nanjing, ChinaNanjing Medical University, Nanjing, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Orthopedics, The Affiliated Jiangsu Shengze Hospital of Nanjing Medical University, Suzhou, ChinaDepartment of Orthopedics, Xishan People’s Hospital, Wuxi, ChinaNanjing Medical University, Nanjing, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Orthopedics, The First Affiliated Hospital of Xuzhou Medical University, Xuzhou, ChinaAs a worldwide medical problem, spinal cord injury has no clear and effective treatment to improve its prognosis. Hence, new treatment strategies for spinal cord injury with good therapeutic efficacy have been actively pursued. As a new drug loading system, acetal dextran nanoparticles (SAD) have good biocompatibility and biodegradability. Therefore, we designed spermine-functionalized acetal-dextran (SAD) nanoparticles and encapsulated paclitaxel (PCL) into them. This design can ensure the sustained release of paclitaxel in the injured area for 4 days and promote the extension of nerve processes in vitro. In our experiment, we found that paclitaxel-loaded SAD nanoparticles (PCL@SAD) decreased the level of chondroitin sulfate proteoglycan in the rat spinal cord injury model, which reduced the scar repair of the injured site and changed the inhibitory environment after spinal cord injury. This reveals that PCL@SAD can effectively protect the injured spinal cord and ultimately improve the functional recovery of the injured spinal cord. One single injection of PCL@SAD shows better therapeutic effect than that of PCL. This study opens an exciting perspective toward the application of neuroprotective PCL@SAD for the treatment of severe neurological diseases.https://www.frontiersin.org/articles/10.3389/fphar.2022.957433/fullspinal cord injuryspermine-functionalized acetalated dextranpaclitaxelchondroitin sulfate proteoglycan inhibitionspinal cord injury |
| spellingShingle | Xinzhu Zhang Xinzhu Zhang Wu Xiong Wu Xiong Guang Kong Guang Kong Guang Kong Yushan Zhen Qiang Zeng Siming Wang Siming Wang Sheng Chen Jun Gu Cong Li Cong Li Kaijin Guo Paclitaxel-incorporated nanoparticles improve functional recovery after spinal cord injury Frontiers in Pharmacology spinal cord injury spermine-functionalized acetalated dextran paclitaxel chondroitin sulfate proteoglycan inhibition spinal cord injury |
| title | Paclitaxel-incorporated nanoparticles improve functional recovery after spinal cord injury |
| title_full | Paclitaxel-incorporated nanoparticles improve functional recovery after spinal cord injury |
| title_fullStr | Paclitaxel-incorporated nanoparticles improve functional recovery after spinal cord injury |
| title_full_unstemmed | Paclitaxel-incorporated nanoparticles improve functional recovery after spinal cord injury |
| title_short | Paclitaxel-incorporated nanoparticles improve functional recovery after spinal cord injury |
| title_sort | paclitaxel incorporated nanoparticles improve functional recovery after spinal cord injury |
| topic | spinal cord injury spermine-functionalized acetalated dextran paclitaxel chondroitin sulfate proteoglycan inhibition spinal cord injury |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.957433/full |
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