The impact of time from injury to surgery on the risk of neuropathic pain after traumatic spinal cord injury
Abstract Traumatic spinal cord injury (SCI) is a devastating neurological disorder often accompanied by neuropathic pain (NeP), significantly affecting patients' quality of life. This retrospective study aimed to investigate the impact of the time from injury to surgery on the development of Ne...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-11-01
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| Series: | Journal of Orthopaedic Surgery and Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13018-023-04355-7 |
| _version_ | 1797630112447856640 |
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| author | Tengbin Shi Zhengxi Yu Zhi Chen Dingwei Wu Zhenyu Wang Wenge Liu |
| author_facet | Tengbin Shi Zhengxi Yu Zhi Chen Dingwei Wu Zhenyu Wang Wenge Liu |
| author_sort | Tengbin Shi |
| collection | DOAJ |
| description | Abstract Traumatic spinal cord injury (SCI) is a devastating neurological disorder often accompanied by neuropathic pain (NeP), significantly affecting patients' quality of life. This retrospective study aimed to investigate the impact of the time from injury to surgery on the development of NeP following traumatic SCI. Medical records of patients with traumatic SCI who underwent surgical intervention between January 2017 and January 2021 at two specialized centers were reviewed. Variables associated with NeP including demographics, injury profiles, medical history, surgical details, and pain assessments were investigated. Independent risk factors related to NeP were identified using multivariate logistic regression analysis. A total of 320 patients met the inclusion criteria, with 245 (76.6%) being male and a mean age of 56.5 ± 13.2 years. NeP was identified in 48.4% of patients (155 of 320). The multivariate analysis identifies age at injury, Injury Severity Score, and the neurological level of injury as independent risk factors for the development of NeP in both AIS A and AIS B, C, and D subgroups. Additionally, a significant association between the time from injury to surgery and NeP was observed in AIS B, C, and D patients, while no such association was found in AIS A patients. This study highlights the benefits of early and ultra-early surgical intervention in preventing NeP in patients with incomplete traumatic SCI (AIS B, C, and D), underscoring the importance of optimizing surgical timing to improve patient outcomes. Prospective studies are warranted to establish evidence-based surgical guidelines for managing traumatic SCI and preventing NeP effectively. |
| first_indexed | 2024-03-11T11:02:18Z |
| format | Article |
| id | doaj.art-8a4ef99366a142f5bb55f8df4558d861 |
| institution | Directory Open Access Journal |
| issn | 1749-799X |
| language | English |
| last_indexed | 2024-03-11T11:02:18Z |
| publishDate | 2023-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Orthopaedic Surgery and Research |
| spelling | doaj.art-8a4ef99366a142f5bb55f8df4558d8612023-11-12T12:24:27ZengBMCJournal of Orthopaedic Surgery and Research1749-799X2023-11-0118111110.1186/s13018-023-04355-7The impact of time from injury to surgery on the risk of neuropathic pain after traumatic spinal cord injuryTengbin Shi0Zhengxi Yu1Zhi Chen2Dingwei Wu3Zhenyu Wang4Wenge Liu5Fujian Medical University Union HospitalDepartment of Minimally Invasive Spinal Surgery, The Affiliated Hospital of Putian UniversityDepartment of Orthopedics, Fujian Medical University Union HospitalDepartment of Orthopedics, Fujian Medical University Union HospitalDepartment of Orthopedics, Fujian Medical University Union HospitalDepartment of Orthopedics, Fujian Medical University Union HospitalAbstract Traumatic spinal cord injury (SCI) is a devastating neurological disorder often accompanied by neuropathic pain (NeP), significantly affecting patients' quality of life. This retrospective study aimed to investigate the impact of the time from injury to surgery on the development of NeP following traumatic SCI. Medical records of patients with traumatic SCI who underwent surgical intervention between January 2017 and January 2021 at two specialized centers were reviewed. Variables associated with NeP including demographics, injury profiles, medical history, surgical details, and pain assessments were investigated. Independent risk factors related to NeP were identified using multivariate logistic regression analysis. A total of 320 patients met the inclusion criteria, with 245 (76.6%) being male and a mean age of 56.5 ± 13.2 years. NeP was identified in 48.4% of patients (155 of 320). The multivariate analysis identifies age at injury, Injury Severity Score, and the neurological level of injury as independent risk factors for the development of NeP in both AIS A and AIS B, C, and D subgroups. Additionally, a significant association between the time from injury to surgery and NeP was observed in AIS B, C, and D patients, while no such association was found in AIS A patients. This study highlights the benefits of early and ultra-early surgical intervention in preventing NeP in patients with incomplete traumatic SCI (AIS B, C, and D), underscoring the importance of optimizing surgical timing to improve patient outcomes. Prospective studies are warranted to establish evidence-based surgical guidelines for managing traumatic SCI and preventing NeP effectively.https://doi.org/10.1186/s13018-023-04355-7Traumatic spinal cord injuryNeuralgiaPainNeuropathic painSurgery timing |
| spellingShingle | Tengbin Shi Zhengxi Yu Zhi Chen Dingwei Wu Zhenyu Wang Wenge Liu The impact of time from injury to surgery on the risk of neuropathic pain after traumatic spinal cord injury Journal of Orthopaedic Surgery and Research Traumatic spinal cord injury Neuralgia Pain Neuropathic pain Surgery timing |
| title | The impact of time from injury to surgery on the risk of neuropathic pain after traumatic spinal cord injury |
| title_full | The impact of time from injury to surgery on the risk of neuropathic pain after traumatic spinal cord injury |
| title_fullStr | The impact of time from injury to surgery on the risk of neuropathic pain after traumatic spinal cord injury |
| title_full_unstemmed | The impact of time from injury to surgery on the risk of neuropathic pain after traumatic spinal cord injury |
| title_short | The impact of time from injury to surgery on the risk of neuropathic pain after traumatic spinal cord injury |
| title_sort | impact of time from injury to surgery on the risk of neuropathic pain after traumatic spinal cord injury |
| topic | Traumatic spinal cord injury Neuralgia Pain Neuropathic pain Surgery timing |
| url | https://doi.org/10.1186/s13018-023-04355-7 |
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