Sterubin protects against chemically-induced Alzheimer’s disease by reducing biomarkers of inflammation- IL-6/ IL-β/ TNF-α and oxidative stress- SOD/MDA in rats
Sterubin, a flavanone is an active chemical compound that possesses neuroprotective activity. The current investigation was intended to assess the sterubin effect in scopolamine-activated Alzheimer's disease. The rats were induced with scopolamine (1.5 mg/kg) followed by treatment with sterubin...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-02-01
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| Series: | Saudi Journal of Biological Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1319562X23000050 |
| _version_ | 1811171010766962688 |
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| author | Imran Kazmi Fahad A. Al-Abbasi Muhammad Afzal Muhammad Shahid Nadeem Hisham N. Altayb |
| author_facet | Imran Kazmi Fahad A. Al-Abbasi Muhammad Afzal Muhammad Shahid Nadeem Hisham N. Altayb |
| author_sort | Imran Kazmi |
| collection | DOAJ |
| description | Sterubin, a flavanone is an active chemical compound that possesses neuroprotective activity. The current investigation was intended to assess the sterubin effect in scopolamine-activated Alzheimer's disease. The rats were induced with scopolamine (1.5 mg/kg) followed by treatment with sterubin (10 mg/kg) for 14 days. Behavioural analysis was predictable by the Y-maze test and Morris water test. Biochemical variables like nitric oxide acetylcholinesterase, Choline acetyltransferase, antioxidant markers like superoxide dismutase, glutathione transferase, malondialdehyde, catalase, and myeloperoxidase activity, neuroinflammatory markers such as tumor necrosis factor-alpha, nuclear factor kappa B, interferon-gamma, interleukin (IL-1β), and IL-6 were measured. The result stated that sterubin reversed the oxidative stress parameters, increased motor performance, and lowered the inflammatory markers in scopolamine-induced rats. The study demonstrated that sterubin possesses neuroprotective, anti-inflammatory, and antioxidant properties which can be used as a beneficial medication in AD. |
| first_indexed | 2024-04-10T17:06:22Z |
| format | Article |
| id | doaj.art-8a5122e8b3114fd3973a16ce1200371c |
| institution | Directory Open Access Journal |
| issn | 1319-562X |
| language | English |
| last_indexed | 2024-04-10T17:06:22Z |
| publishDate | 2023-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Saudi Journal of Biological Sciences |
| spelling | doaj.art-8a5122e8b3114fd3973a16ce1200371c2023-02-06T04:05:42ZengElsevierSaudi Journal of Biological Sciences1319-562X2023-02-01302103560Sterubin protects against chemically-induced Alzheimer’s disease by reducing biomarkers of inflammation- IL-6/ IL-β/ TNF-α and oxidative stress- SOD/MDA in ratsImran Kazmi0Fahad A. Al-Abbasi1Muhammad Afzal2Muhammad Shahid Nadeem3Hisham N. Altayb4Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi Arabia; Corresponding author.Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi ArabiaDepartment of Pharmacology, Himalayan Institute of Pharmacy and Research, Rajawala, Dehradun, Uttarakhand, IndiaDepartment of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi ArabiaDepartment of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah 21589, Saudi ArabiaSterubin, a flavanone is an active chemical compound that possesses neuroprotective activity. The current investigation was intended to assess the sterubin effect in scopolamine-activated Alzheimer's disease. The rats were induced with scopolamine (1.5 mg/kg) followed by treatment with sterubin (10 mg/kg) for 14 days. Behavioural analysis was predictable by the Y-maze test and Morris water test. Biochemical variables like nitric oxide acetylcholinesterase, Choline acetyltransferase, antioxidant markers like superoxide dismutase, glutathione transferase, malondialdehyde, catalase, and myeloperoxidase activity, neuroinflammatory markers such as tumor necrosis factor-alpha, nuclear factor kappa B, interferon-gamma, interleukin (IL-1β), and IL-6 were measured. The result stated that sterubin reversed the oxidative stress parameters, increased motor performance, and lowered the inflammatory markers in scopolamine-induced rats. The study demonstrated that sterubin possesses neuroprotective, anti-inflammatory, and antioxidant properties which can be used as a beneficial medication in AD.http://www.sciencedirect.com/science/article/pii/S1319562X23000050Alzheimer’s diseaseNeuroprotectiveNeuroinflammatory markersOxidative stressScopolamineSterubin |
| spellingShingle | Imran Kazmi Fahad A. Al-Abbasi Muhammad Afzal Muhammad Shahid Nadeem Hisham N. Altayb Sterubin protects against chemically-induced Alzheimer’s disease by reducing biomarkers of inflammation- IL-6/ IL-β/ TNF-α and oxidative stress- SOD/MDA in rats Saudi Journal of Biological Sciences Alzheimer’s disease Neuroprotective Neuroinflammatory markers Oxidative stress Scopolamine Sterubin |
| title | Sterubin protects against chemically-induced Alzheimer’s disease by reducing biomarkers of inflammation- IL-6/ IL-β/ TNF-α and oxidative stress- SOD/MDA in rats |
| title_full | Sterubin protects against chemically-induced Alzheimer’s disease by reducing biomarkers of inflammation- IL-6/ IL-β/ TNF-α and oxidative stress- SOD/MDA in rats |
| title_fullStr | Sterubin protects against chemically-induced Alzheimer’s disease by reducing biomarkers of inflammation- IL-6/ IL-β/ TNF-α and oxidative stress- SOD/MDA in rats |
| title_full_unstemmed | Sterubin protects against chemically-induced Alzheimer’s disease by reducing biomarkers of inflammation- IL-6/ IL-β/ TNF-α and oxidative stress- SOD/MDA in rats |
| title_short | Sterubin protects against chemically-induced Alzheimer’s disease by reducing biomarkers of inflammation- IL-6/ IL-β/ TNF-α and oxidative stress- SOD/MDA in rats |
| title_sort | sterubin protects against chemically induced alzheimer s disease by reducing biomarkers of inflammation il 6 il β tnf α and oxidative stress sod mda in rats |
| topic | Alzheimer’s disease Neuroprotective Neuroinflammatory markers Oxidative stress Scopolamine Sterubin |
| url | http://www.sciencedirect.com/science/article/pii/S1319562X23000050 |
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