HLA-DR3 restricted environmental epitopes from the bacterium Clostridium tetani have T cell cross-reactivity to the SLE-related autoantigen SmD

HLA-DR3 restricted environmental epitopes from the bacterium Clostridium tetani have T cell cross-reactivity to the SLE-related autoantigen SmD

HLA-DR3 (DR3) is one of the dominant HLA-DR alleles associated with systemic lupus erythematosus (SLE) susceptibility. Our previous studies showed multiple intramolecular DR3 restricted T cell epitopes in the Smith D (SmD) protein, from which we generated a non-homologous, bacterial epitope mimics l...

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Bibliographic Details
Main Authors: Zhenhuan Zhao, Ashley N. Anderson, Carol C. Kannapell, William W. Kwok, Felicia Gaskin, Shu Man Fu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Immunology
Subjects:
T cell epitope
HLA-DR3
environmental bacteria
molecular mimicry
autoantigen
Smith D (SmD)
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.928374/full

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