Metabolic disorders during pregnancy and postpartum cardiometabolic risk
Hormonal changes during pregnancy can trigger gestational diabetes (GDM), which is constantly increasing. Its main characteristic is pronounced insulin resistance, but it appears to be a multifactorial process involving several metabolic factors; taken together, the latter leads to silent or clinica...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Bioscientifica
2018-05-01
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| Series: | Endocrine Connections |
| Subjects: | |
| Online Access: | http://www.endocrineconnections.com/content/7/5/E1.full |
| _version_ | 1818590873809584128 |
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| author | Angelo Maria Patti Kalliopi Pafili Nikolaos Papanas Manfredi Rizzo |
| author_facet | Angelo Maria Patti Kalliopi Pafili Nikolaos Papanas Manfredi Rizzo |
| author_sort | Angelo Maria Patti |
| collection | DOAJ |
| description | Hormonal changes during pregnancy can trigger gestational diabetes (GDM), which is constantly increasing. Its main characteristic is pronounced insulin resistance, but it appears to be a multifactorial process involving several metabolic factors; taken together, the latter leads to silent or clinically evident cardiovascular (CV) events. Insulin resistance and central adiposity are of crucial importance in the development of metabolic syndrome, and they appear to correlate with CV risk factors, including hypertension and atherogenic dyslipidaemia. Hypertensive disease of pregnancy (HDP) is more likely to be an accompanying co-morbidity in pregnancies complicated with GDM. There is still inconsistent evidence as to whether or not co-existent GDM and HDP have a synergistic effects on postpartum risk of cardiometabolic disease; however, this synergism is becoming more accepted since both these conditions may promote endothelial inflammation and early atherosclerosis. Regardless of the presence or absence of the synergism between GDM and HDP, these conditions need to be dealt early enough, in order to reduce CV morbidity and to improve health outcomes for both women and their offspring. |
| first_indexed | 2024-12-16T10:03:28Z |
| format | Article |
| id | doaj.art-8a56864138de44b78766652413f75365 |
| institution | Directory Open Access Journal |
| issn | 2049-3614 2049-3614 |
| language | English |
| last_indexed | 2024-12-16T10:03:28Z |
| publishDate | 2018-05-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Connections |
| spelling | doaj.art-8a56864138de44b78766652413f753652022-12-21T22:35:44ZengBioscientificaEndocrine Connections2049-36142049-36142018-05-0175E1E4https://doi.org/10.1530/EC-18-0130Metabolic disorders during pregnancy and postpartum cardiometabolic riskAngelo Maria Patti0Kalliopi Pafili1Nikolaos Papanas2Manfredi Rizzo3Department of Internal Medicine and Medical Specialties, University of Palermo, Palermo, ItalyDiabetes Centre, Second Department of Internal Medicine, Democritus University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis, GreeceDiabetes Centre, Second Department of Internal Medicine, Democritus University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis, GreeceDepartment of Internal Medicine and Medical Specialties, University of Palermo, Palermo, ItalyHormonal changes during pregnancy can trigger gestational diabetes (GDM), which is constantly increasing. Its main characteristic is pronounced insulin resistance, but it appears to be a multifactorial process involving several metabolic factors; taken together, the latter leads to silent or clinically evident cardiovascular (CV) events. Insulin resistance and central adiposity are of crucial importance in the development of metabolic syndrome, and they appear to correlate with CV risk factors, including hypertension and atherogenic dyslipidaemia. Hypertensive disease of pregnancy (HDP) is more likely to be an accompanying co-morbidity in pregnancies complicated with GDM. There is still inconsistent evidence as to whether or not co-existent GDM and HDP have a synergistic effects on postpartum risk of cardiometabolic disease; however, this synergism is becoming more accepted since both these conditions may promote endothelial inflammation and early atherosclerosis. Regardless of the presence or absence of the synergism between GDM and HDP, these conditions need to be dealt early enough, in order to reduce CV morbidity and to improve health outcomes for both women and their offspring.http://www.endocrineconnections.com/content/7/5/E1.fullcardiovascular riskgestational diabeteshypertensionmetabolic syndrome |
| spellingShingle | Angelo Maria Patti Kalliopi Pafili Nikolaos Papanas Manfredi Rizzo Metabolic disorders during pregnancy and postpartum cardiometabolic risk Endocrine Connections cardiovascular risk gestational diabetes hypertension metabolic syndrome |
| title | Metabolic disorders during pregnancy and postpartum cardiometabolic risk |
| title_full | Metabolic disorders during pregnancy and postpartum cardiometabolic risk |
| title_fullStr | Metabolic disorders during pregnancy and postpartum cardiometabolic risk |
| title_full_unstemmed | Metabolic disorders during pregnancy and postpartum cardiometabolic risk |
| title_short | Metabolic disorders during pregnancy and postpartum cardiometabolic risk |
| title_sort | metabolic disorders during pregnancy and postpartum cardiometabolic risk |
| topic | cardiovascular risk gestational diabetes hypertension metabolic syndrome |
| url | http://www.endocrineconnections.com/content/7/5/E1.full |
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