The effect of respiration-induced target motion on 3D magnetic resonance images used to guide radiotherapy
Background and purpose: 3D Magnetic Resonance Imaging (MRI) is used in radiation therapy for reference planning and, lately, for adaptive treatments on MR accelerators. This study aimed to investigate the impact of different types of respiratory motion on the apparent target position and extent in s...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-10-01
|
| Series: | Physics and Imaging in Radiation Oncology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405631622001002 |
| _version_ | 1828090210552905728 |
|---|---|
| author | Anders Bertelsen Uffe Bernchou Tine Schytte Carsten Brink Faisal Mahmood |
| author_facet | Anders Bertelsen Uffe Bernchou Tine Schytte Carsten Brink Faisal Mahmood |
| author_sort | Anders Bertelsen |
| collection | DOAJ |
| description | Background and purpose: 3D Magnetic Resonance Imaging (MRI) is used in radiation therapy for reference planning and, lately, for adaptive treatments on MR accelerators. This study aimed to investigate the impact of different types of respiratory motion on the apparent target position and extent in such scans. Materials and methods: An MRI motion phantom with a 30 mm diameter target was used to simulate cranial-caudal (CC) motion and imaged at an MR-Linac using a standard clinically released 3D T2w sequence. Scans were acquired for each combination of functions (sin(t), sin4(t) and sin12(t)), peak-to-peak amplitudes (5, 10, 15 and 20 mm), and periods (4, 5 and 6 s). Furthermore, respiration CC motion patterns from two patients were used. Motion functions were shifted such that the time average target position would match a static reference scan at 0-position. The target was automatically identified in coronal and sagittal images using k-means clustering. The mean position and area of the target were calculated and compared to the reference scan. Results: Artefacts increased with amplitude and depended on the motion type. Sin(t) and sin4(t) oscillations resulted in a blurring of the target, which led to an increased target area, while sin12(t) motion did not show significant changes in the target area. However, for the sin12(t) motion, the offset in apparent position was prominent, while that was not the case for the sin(t) and sin4(t) motion. The patient respiration motion profiles showed similar trends. Conclusions: In 3D MRI, target motion can change apparent tumour extent and apparent position. The changes increase with motion amplitude and depend on the motion type. |
| first_indexed | 2024-04-11T05:54:30Z |
| format | Article |
| id | doaj.art-8a5977546a3c475983b3fb4e674f20e8 |
| institution | Directory Open Access Journal |
| issn | 2405-6316 |
| language | English |
| last_indexed | 2024-04-11T05:54:30Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Physics and Imaging in Radiation Oncology |
| spelling | doaj.art-8a5977546a3c475983b3fb4e674f20e82022-12-22T04:41:58ZengElsevierPhysics and Imaging in Radiation Oncology2405-63162022-10-0124167172The effect of respiration-induced target motion on 3D magnetic resonance images used to guide radiotherapyAnders Bertelsen0Uffe Bernchou1Tine Schytte2Carsten Brink3Faisal Mahmood4Laboratory of Radiation Physics, Department of Oncology, Odense University Hospital, Odense, Denmark; Corresponding author.Laboratory of Radiation Physics, Department of Oncology, Odense University Hospital, Odense, Denmark; Department of Clinical Research, University of Southern Denmark, Odense, DenmarkDepartment of Clinical Research, University of Southern Denmark, Odense, Denmark; Department of Oncology, Odense University Hospital, Odense, DenmarkLaboratory of Radiation Physics, Department of Oncology, Odense University Hospital, Odense, Denmark; Department of Clinical Research, University of Southern Denmark, Odense, DenmarkLaboratory of Radiation Physics, Department of Oncology, Odense University Hospital, Odense, Denmark; Department of Clinical Research, University of Southern Denmark, Odense, DenmarkBackground and purpose: 3D Magnetic Resonance Imaging (MRI) is used in radiation therapy for reference planning and, lately, for adaptive treatments on MR accelerators. This study aimed to investigate the impact of different types of respiratory motion on the apparent target position and extent in such scans. Materials and methods: An MRI motion phantom with a 30 mm diameter target was used to simulate cranial-caudal (CC) motion and imaged at an MR-Linac using a standard clinically released 3D T2w sequence. Scans were acquired for each combination of functions (sin(t), sin4(t) and sin12(t)), peak-to-peak amplitudes (5, 10, 15 and 20 mm), and periods (4, 5 and 6 s). Furthermore, respiration CC motion patterns from two patients were used. Motion functions were shifted such that the time average target position would match a static reference scan at 0-position. The target was automatically identified in coronal and sagittal images using k-means clustering. The mean position and area of the target were calculated and compared to the reference scan. Results: Artefacts increased with amplitude and depended on the motion type. Sin(t) and sin4(t) oscillations resulted in a blurring of the target, which led to an increased target area, while sin12(t) motion did not show significant changes in the target area. However, for the sin12(t) motion, the offset in apparent position was prominent, while that was not the case for the sin(t) and sin4(t) motion. The patient respiration motion profiles showed similar trends. Conclusions: In 3D MRI, target motion can change apparent tumour extent and apparent position. The changes increase with motion amplitude and depend on the motion type.http://www.sciencedirect.com/science/article/pii/S2405631622001002Online adaptiveArtefactsMR acceleratorMR-guided radio therapyRespiration motionMRgRT |
| spellingShingle | Anders Bertelsen Uffe Bernchou Tine Schytte Carsten Brink Faisal Mahmood The effect of respiration-induced target motion on 3D magnetic resonance images used to guide radiotherapy Physics and Imaging in Radiation Oncology Online adaptive Artefacts MR accelerator MR-guided radio therapy Respiration motion MRgRT |
| title | The effect of respiration-induced target motion on 3D magnetic resonance images used to guide radiotherapy |
| title_full | The effect of respiration-induced target motion on 3D magnetic resonance images used to guide radiotherapy |
| title_fullStr | The effect of respiration-induced target motion on 3D magnetic resonance images used to guide radiotherapy |
| title_full_unstemmed | The effect of respiration-induced target motion on 3D magnetic resonance images used to guide radiotherapy |
| title_short | The effect of respiration-induced target motion on 3D magnetic resonance images used to guide radiotherapy |
| title_sort | effect of respiration induced target motion on 3d magnetic resonance images used to guide radiotherapy |
| topic | Online adaptive Artefacts MR accelerator MR-guided radio therapy Respiration motion MRgRT |
| url | http://www.sciencedirect.com/science/article/pii/S2405631622001002 |
| work_keys_str_mv | AT andersbertelsen theeffectofrespirationinducedtargetmotionon3dmagneticresonanceimagesusedtoguideradiotherapy AT uffebernchou theeffectofrespirationinducedtargetmotionon3dmagneticresonanceimagesusedtoguideradiotherapy AT tineschytte theeffectofrespirationinducedtargetmotionon3dmagneticresonanceimagesusedtoguideradiotherapy AT carstenbrink theeffectofrespirationinducedtargetmotionon3dmagneticresonanceimagesusedtoguideradiotherapy AT faisalmahmood theeffectofrespirationinducedtargetmotionon3dmagneticresonanceimagesusedtoguideradiotherapy AT andersbertelsen effectofrespirationinducedtargetmotionon3dmagneticresonanceimagesusedtoguideradiotherapy AT uffebernchou effectofrespirationinducedtargetmotionon3dmagneticresonanceimagesusedtoguideradiotherapy AT tineschytte effectofrespirationinducedtargetmotionon3dmagneticresonanceimagesusedtoguideradiotherapy AT carstenbrink effectofrespirationinducedtargetmotionon3dmagneticresonanceimagesusedtoguideradiotherapy AT faisalmahmood effectofrespirationinducedtargetmotionon3dmagneticresonanceimagesusedtoguideradiotherapy |