Analysis of the role of Igf2 in adrenal tumour development in transgenic mouse models.

Analysis of the role of Igf2 in adrenal tumour development in transgenic mouse models.

Adrenal cortical carcinomas (ACC) are rare but aggressive tumours associated with poor prognosis. The two most frequent alterations in ACC in patients are overexpression of the growth factor IGF2 and constitutive activation of Wnt/β-catenin signalling. Using a transgenic mouse model, we have previou...

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Main Authors: Coralie Drelon, Annabel Berthon, Bruno Ragazzon, Frédérique Tissier, Roberto Bandiera, Isabelle Sahut-Barnola, Cyrille de Joussineau, Marie Batisse-Lignier, Anne-Marie Lefrançois-Martinez, Jérôme Bertherat, Antoine Martinez, Pierre Val
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22952916/pdf/?tool=EBI

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