Establishment and verification of prediction model of occult peritoneal metastasis in advanced gastric cancer
Abstract Background To investigate the risk factors associated with the development of occult peritoneal metastasis in advanced gastric cancer, and establish and externally validate a nomogram for predicting the occurrence of occult peritoneal metastasis in patients with advanced gastric cancer. Met...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-10-01
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| Series: | World Journal of Surgical Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12957-023-03188-2 |
| _version_ | 1827634046397579264 |
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| author | Hengfei Gao Kangkang Ji Linsen Bao Hao Chen Chen Lin Min Feng Liang Tao Meng Wang |
| author_facet | Hengfei Gao Kangkang Ji Linsen Bao Hao Chen Chen Lin Min Feng Liang Tao Meng Wang |
| author_sort | Hengfei Gao |
| collection | DOAJ |
| description | Abstract Background To investigate the risk factors associated with the development of occult peritoneal metastasis in advanced gastric cancer, and establish and externally validate a nomogram for predicting the occurrence of occult peritoneal metastasis in patients with advanced gastric cancer. Methods A total of 111 patients with advanced gastric cancer who underwent laparoscopic exploration or peritoneal lavage cytology examination at the Affiliated Drum Tower Hospital of Nanjing University Medical School from August 2014 to December 2021 were retrospectively analyzed. The patients diagnosed between 2019 and 2021 were assigned to the training set (n = 64), while those diagnosed between 2014 and 2016 constituted the external validation set (n = 47). In the training set, patients were classified into two groups based on preoperative imaging and postoperative pathological data: the occult peritoneal metastasis group (OPMG) and the peritoneal metastasis negative group (PMNG). In the validation set, patients were classified into the occult peritoneal metastasis group (CY1P0, OPMG) and the peritoneal metastasis negative group (CY0P0, PMNG) based on peritoneal lavage cytology results. A nomogram was constructed using univariate and multivariate analyses. The performance of the nomogram was evaluated using Harrell’s C-index, the area under the receiver operating characteristic curve (AUC), decision curve analysis (DCA), and calibration plots. Results This study analyzed 22 potential variables of OPM in 111 gastric cancer patients who underwent laparoscopic exploration or peritoneal lavage cytology examination. Logistic regression analysis results showed that Lauren classification, CLDN18.2 score and CA125 were independent risk factors for OPM in patients with gastric cancer. We developed a simple and easy-to-use prediction nomogram of occult peritoneal metastasis in advanced gastric cancer. This nomogram had an excellent diagnostic performance. The AUC of the bootstrap model in the training set was 0.771 and in the validation set was 0.711. This model showed a good fitting and calibration and positive net benefits in decision curve analysis. Conclusion We have developed a prediction nomogram of OPM for gastric cancer. This novel nomogram has the potential to enhance diagnostic accuracy for occult peritoneal metastasis in gastric cancer patients. |
| first_indexed | 2024-03-09T15:09:00Z |
| format | Article |
| id | doaj.art-8a5af29591ea4e08a58aa96bcf97b4a7 |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-03-09T15:09:00Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-8a5af29591ea4e08a58aa96bcf97b4a72023-11-26T13:31:36ZengBMCWorld Journal of Surgical Oncology1477-78192023-10-0121111210.1186/s12957-023-03188-2Establishment and verification of prediction model of occult peritoneal metastasis in advanced gastric cancerHengfei Gao0Kangkang Ji1Linsen Bao2Hao Chen3Chen Lin4Min Feng5Liang Tao6Meng Wang7Department of General Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical SchoolDepartment of Gastrointestinal, Fuyang People’s HospitalDepartment of General Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical SchoolDepartment of General Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical SchoolDepartment of General Surgery, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical UniversityDepartment of General Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical SchoolDepartment of General Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical SchoolDepartment of General Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical SchoolAbstract Background To investigate the risk factors associated with the development of occult peritoneal metastasis in advanced gastric cancer, and establish and externally validate a nomogram for predicting the occurrence of occult peritoneal metastasis in patients with advanced gastric cancer. Methods A total of 111 patients with advanced gastric cancer who underwent laparoscopic exploration or peritoneal lavage cytology examination at the Affiliated Drum Tower Hospital of Nanjing University Medical School from August 2014 to December 2021 were retrospectively analyzed. The patients diagnosed between 2019 and 2021 were assigned to the training set (n = 64), while those diagnosed between 2014 and 2016 constituted the external validation set (n = 47). In the training set, patients were classified into two groups based on preoperative imaging and postoperative pathological data: the occult peritoneal metastasis group (OPMG) and the peritoneal metastasis negative group (PMNG). In the validation set, patients were classified into the occult peritoneal metastasis group (CY1P0, OPMG) and the peritoneal metastasis negative group (CY0P0, PMNG) based on peritoneal lavage cytology results. A nomogram was constructed using univariate and multivariate analyses. The performance of the nomogram was evaluated using Harrell’s C-index, the area under the receiver operating characteristic curve (AUC), decision curve analysis (DCA), and calibration plots. Results This study analyzed 22 potential variables of OPM in 111 gastric cancer patients who underwent laparoscopic exploration or peritoneal lavage cytology examination. Logistic regression analysis results showed that Lauren classification, CLDN18.2 score and CA125 were independent risk factors for OPM in patients with gastric cancer. We developed a simple and easy-to-use prediction nomogram of occult peritoneal metastasis in advanced gastric cancer. This nomogram had an excellent diagnostic performance. The AUC of the bootstrap model in the training set was 0.771 and in the validation set was 0.711. This model showed a good fitting and calibration and positive net benefits in decision curve analysis. Conclusion We have developed a prediction nomogram of OPM for gastric cancer. This novel nomogram has the potential to enhance diagnostic accuracy for occult peritoneal metastasis in gastric cancer patients.https://doi.org/10.1186/s12957-023-03188-2Gastric cancerClaudin18.2CA125Occult peritoneal metastasisNomogram |
| spellingShingle | Hengfei Gao Kangkang Ji Linsen Bao Hao Chen Chen Lin Min Feng Liang Tao Meng Wang Establishment and verification of prediction model of occult peritoneal metastasis in advanced gastric cancer World Journal of Surgical Oncology Gastric cancer Claudin18.2 CA125 Occult peritoneal metastasis Nomogram |
| title | Establishment and verification of prediction model of occult peritoneal metastasis in advanced gastric cancer |
| title_full | Establishment and verification of prediction model of occult peritoneal metastasis in advanced gastric cancer |
| title_fullStr | Establishment and verification of prediction model of occult peritoneal metastasis in advanced gastric cancer |
| title_full_unstemmed | Establishment and verification of prediction model of occult peritoneal metastasis in advanced gastric cancer |
| title_short | Establishment and verification of prediction model of occult peritoneal metastasis in advanced gastric cancer |
| title_sort | establishment and verification of prediction model of occult peritoneal metastasis in advanced gastric cancer |
| topic | Gastric cancer Claudin18.2 CA125 Occult peritoneal metastasis Nomogram |
| url | https://doi.org/10.1186/s12957-023-03188-2 |
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