Family History of Cancers Increases Risk of Renal Cell Carcinoma in a Chinese Population
Siwei Xing,1,* Xiaohao Ruan,1,* Jingyi Huang,1,* Jiaqi Yan,1 Wenhao Lin,1 Jinlun Huang,1 Jiacheng Liu,1 Da Huang,1 Rong Na,2 Danfeng Xu1 1Department of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 2Division...
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| Format: | Article |
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Dove Medical Press
2022-08-01
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| Series: | Cancer Management and Research |
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| Online Access: | https://www.dovepress.com/family-history-of-cancers-increases-risk-of-renal-cell-carcinoma-in-a--peer-reviewed-fulltext-article-CMAR |
| _version_ | 1798037388304318464 |
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| author | Xing S Ruan X Huang J Yan J Lin W Huang J Liu J Huang D Na R Xu D |
| author_facet | Xing S Ruan X Huang J Yan J Lin W Huang J Liu J Huang D Na R Xu D |
| author_sort | Xing S |
| collection | DOAJ |
| description | Siwei Xing,1,* Xiaohao Ruan,1,* Jingyi Huang,1,* Jiaqi Yan,1 Wenhao Lin,1 Jinlun Huang,1 Jiacheng Liu,1 Da Huang,1 Rong Na,2 Danfeng Xu1 1Department of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 2Division of Urology, Department of Surgery, Queen Mary Hospital, The University of Hong Kong, Hong Kong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Rong Na, Division of Urology, Department of Surgery, Queen Mary Hospital, The University of Hong Kong, 102 Pok Fu Lam Road, Hong Kong, People’s Republic of China, Email narong.hs@gmail.com Da Huang, Department of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, People’s Republic of China, Email huangdasjtu@gmail.comPurpose: To explore the impact of family history (FH) on renal cell carcinoma (RCC) and its pathological subtype clear cell RCC (ccRCC) in a Chinese population; a significant association has previously been determined not only in familial cancer syndrome but also in sporadic cases in western populations.Methods: Consecutive patients with kidney tumors from October 2017 to May 2021 at a tertiary hospital in Shanghai were enrolled in the study. Demographic and clinical information was collected, including age, gender, FH (positive or negative, types of cancers, degree of relatives, etc.), pathological diagnosis, and Fuhrman grades.Results: A positive FH of any cancer was observed in 26.5% of the RCC patients, while only 16.8% patients with benign kidney tumor were found to have a positive FH. A strong correlation was observed between FH of any cancers in first-degree relatives and RCC (odds ratio [OR]=4.60, 95% confidence interval [CI]: 1.95– 10.85, P=5.50× 10− 5) or ccRCC (OR=4.63, 95% CI: 1.95– 11.02, P=9.63× 10− 5). In subgroup analysis, FH of digestive cancers was significantly associated with RCC (OR=4.42, 95% CI: 1.35– 14.51, P=0.005) or ccRCC (OR=4.14, 95% CI: 1.25– 13.75, P=6.84× 10− 4). Similar results were found in multivariate analyses. However, no significant association was observed between FH and age at onset.Conclusion: FH was an independent risk factor for RCC and ccRCC in this Chinese population. FH of any cancer in first-degree relatives and FH of digestive cancers were found to be the most significant risk factors for kidney cancers.Keywords: Chinese population, family history, renal cell carcinoma, risk factor, multivariate regression analysis |
| first_indexed | 2024-04-11T21:25:54Z |
| format | Article |
| id | doaj.art-8a5cbdb2d980473e87d38316dcfaaf77 |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-04-11T21:25:54Z |
| publishDate | 2022-08-01 |
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| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-8a5cbdb2d980473e87d38316dcfaaf772022-12-22T04:02:24ZengDove Medical PressCancer Management and Research1179-13222022-08-01Volume 142561256877800Family History of Cancers Increases Risk of Renal Cell Carcinoma in a Chinese PopulationXing SRuan XHuang JYan JLin WHuang JLiu JHuang DNa RXu DSiwei Xing,1,* Xiaohao Ruan,1,* Jingyi Huang,1,* Jiaqi Yan,1 Wenhao Lin,1 Jinlun Huang,1 Jiacheng Liu,1 Da Huang,1 Rong Na,2 Danfeng Xu1 1Department of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 2Division of Urology, Department of Surgery, Queen Mary Hospital, The University of Hong Kong, Hong Kong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Rong Na, Division of Urology, Department of Surgery, Queen Mary Hospital, The University of Hong Kong, 102 Pok Fu Lam Road, Hong Kong, People’s Republic of China, Email narong.hs@gmail.com Da Huang, Department of Urology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, People’s Republic of China, Email huangdasjtu@gmail.comPurpose: To explore the impact of family history (FH) on renal cell carcinoma (RCC) and its pathological subtype clear cell RCC (ccRCC) in a Chinese population; a significant association has previously been determined not only in familial cancer syndrome but also in sporadic cases in western populations.Methods: Consecutive patients with kidney tumors from October 2017 to May 2021 at a tertiary hospital in Shanghai were enrolled in the study. Demographic and clinical information was collected, including age, gender, FH (positive or negative, types of cancers, degree of relatives, etc.), pathological diagnosis, and Fuhrman grades.Results: A positive FH of any cancer was observed in 26.5% of the RCC patients, while only 16.8% patients with benign kidney tumor were found to have a positive FH. A strong correlation was observed between FH of any cancers in first-degree relatives and RCC (odds ratio [OR]=4.60, 95% confidence interval [CI]: 1.95– 10.85, P=5.50× 10− 5) or ccRCC (OR=4.63, 95% CI: 1.95– 11.02, P=9.63× 10− 5). In subgroup analysis, FH of digestive cancers was significantly associated with RCC (OR=4.42, 95% CI: 1.35– 14.51, P=0.005) or ccRCC (OR=4.14, 95% CI: 1.25– 13.75, P=6.84× 10− 4). Similar results were found in multivariate analyses. However, no significant association was observed between FH and age at onset.Conclusion: FH was an independent risk factor for RCC and ccRCC in this Chinese population. FH of any cancer in first-degree relatives and FH of digestive cancers were found to be the most significant risk factors for kidney cancers.Keywords: Chinese population, family history, renal cell carcinoma, risk factor, multivariate regression analysishttps://www.dovepress.com/family-history-of-cancers-increases-risk-of-renal-cell-carcinoma-in-a--peer-reviewed-fulltext-article-CMARchinese populationfamily historyrenal cell carcinomarisk factormultivariate regression analysis |
| spellingShingle | Xing S Ruan X Huang J Yan J Lin W Huang J Liu J Huang D Na R Xu D Family History of Cancers Increases Risk of Renal Cell Carcinoma in a Chinese Population Cancer Management and Research chinese population family history renal cell carcinoma risk factor multivariate regression analysis |
| title | Family History of Cancers Increases Risk of Renal Cell Carcinoma in a Chinese Population |
| title_full | Family History of Cancers Increases Risk of Renal Cell Carcinoma in a Chinese Population |
| title_fullStr | Family History of Cancers Increases Risk of Renal Cell Carcinoma in a Chinese Population |
| title_full_unstemmed | Family History of Cancers Increases Risk of Renal Cell Carcinoma in a Chinese Population |
| title_short | Family History of Cancers Increases Risk of Renal Cell Carcinoma in a Chinese Population |
| title_sort | family history of cancers increases risk of renal cell carcinoma in a chinese population |
| topic | chinese population family history renal cell carcinoma risk factor multivariate regression analysis |
| url | https://www.dovepress.com/family-history-of-cancers-increases-risk-of-renal-cell-carcinoma-in-a--peer-reviewed-fulltext-article-CMAR |
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