OTX015 PROTACs: Emerging Novel Therapeutic Agents in Cancer Treatment
Cancer is a wide-spreading disease. Its count goes on increasing and became the second leading cause of death in respect of diseases. New cancer-targeting molecules are explored. In this study, we tried to collect information about one such molecule, OTX015. Articles were searched across reputed sea...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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EDP Sciences
2024-01-01
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| Series: | BIO Web of Conferences |
| Online Access: | https://www.bio-conferences.org/articles/bioconf/pdf/2024/05/bioconf_rtbs2024_01038.pdf |
| _version_ | 1797352918871965696 |
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| author | Kaur Rajwinder Singh Pargat Kaur Amritpal Chaudhary Gaurav Choudhary Diksha Kaur Paranjeet Kumar Sahu Sanjeev |
| author_facet | Kaur Rajwinder Singh Pargat Kaur Amritpal Chaudhary Gaurav Choudhary Diksha Kaur Paranjeet Kumar Sahu Sanjeev |
| author_sort | Kaur Rajwinder |
| collection | DOAJ |
| description | Cancer is a wide-spreading disease. Its count goes on increasing and became the second leading cause of death in respect of diseases. New cancer-targeting molecules are explored. In this study, we tried to collect information about one such molecule, OTX015. Articles were searched across reputed search engines and publishers such as Cochrane, EMBASE, The Lancet, PubMed, GoogleScholar, ScienceDirect, Wiley Online, Springer and Bentham Science by using different keywords: “OTX015”, “Cancer”, “Small molecule PROTACs”, “BRD/BET” and “BET inhibitors”. The quality papers were retrieved, studied, categorized into different sections, analyzed, and used for article writing.OTX015 is a novel molecule in clinical trials. It showed some promising results in various cancers as well as other diseases like latent-HIV with the least side-effects.This article will give an insight into Small Molecules as PROTACs, their advantages and disadvantages, OTX015 and its PROTAC ARV- 825. It is advised that more research/studies are required to be carried out to know more about OTX015 and other PROTACs, their advancements, receptors, and mechanism/ mode of action to know their abilities to work against proteins involving diseases. |
| first_indexed | 2024-03-08T13:23:41Z |
| format | Article |
| id | doaj.art-8a5d4ba7ba5a495f9dd780dcd76893c5 |
| institution | Directory Open Access Journal |
| issn | 2117-4458 |
| language | English |
| last_indexed | 2024-03-08T13:23:41Z |
| publishDate | 2024-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | BIO Web of Conferences |
| spelling | doaj.art-8a5d4ba7ba5a495f9dd780dcd76893c52024-01-17T15:02:13ZengEDP SciencesBIO Web of Conferences2117-44582024-01-01860103810.1051/bioconf/20248601038bioconf_rtbs2024_01038OTX015 PROTACs: Emerging Novel Therapeutic Agents in Cancer TreatmentKaur Rajwinder0Singh Pargat1Kaur Amritpal2Chaudhary Gaurav3Choudhary Diksha4Kaur Paranjeet5Kumar Sahu Sanjeev6Chitkara College of Pharmacy, Chitkara UniversityLambton CollegeChitkara College of Pharmacy, Chitkara UniversityDepartment of Pharmaceutical, Ministry of Chemicals &FertilisersChitkara College of Pharmacy, Chitkara UniversityChitkara College of Pharmacy, Chitkara UniversitySchool of Pharmaceutical Sciences, Lovely Professional UniversityCancer is a wide-spreading disease. Its count goes on increasing and became the second leading cause of death in respect of diseases. New cancer-targeting molecules are explored. In this study, we tried to collect information about one such molecule, OTX015. Articles were searched across reputed search engines and publishers such as Cochrane, EMBASE, The Lancet, PubMed, GoogleScholar, ScienceDirect, Wiley Online, Springer and Bentham Science by using different keywords: “OTX015”, “Cancer”, “Small molecule PROTACs”, “BRD/BET” and “BET inhibitors”. The quality papers were retrieved, studied, categorized into different sections, analyzed, and used for article writing.OTX015 is a novel molecule in clinical trials. It showed some promising results in various cancers as well as other diseases like latent-HIV with the least side-effects.This article will give an insight into Small Molecules as PROTACs, their advantages and disadvantages, OTX015 and its PROTAC ARV- 825. It is advised that more research/studies are required to be carried out to know more about OTX015 and other PROTACs, their advancements, receptors, and mechanism/ mode of action to know their abilities to work against proteins involving diseases.https://www.bio-conferences.org/articles/bioconf/pdf/2024/05/bioconf_rtbs2024_01038.pdf |
| spellingShingle | Kaur Rajwinder Singh Pargat Kaur Amritpal Chaudhary Gaurav Choudhary Diksha Kaur Paranjeet Kumar Sahu Sanjeev OTX015 PROTACs: Emerging Novel Therapeutic Agents in Cancer Treatment BIO Web of Conferences |
| title | OTX015 PROTACs: Emerging Novel Therapeutic Agents in Cancer Treatment |
| title_full | OTX015 PROTACs: Emerging Novel Therapeutic Agents in Cancer Treatment |
| title_fullStr | OTX015 PROTACs: Emerging Novel Therapeutic Agents in Cancer Treatment |
| title_full_unstemmed | OTX015 PROTACs: Emerging Novel Therapeutic Agents in Cancer Treatment |
| title_short | OTX015 PROTACs: Emerging Novel Therapeutic Agents in Cancer Treatment |
| title_sort | otx015 protacs emerging novel therapeutic agents in cancer treatment |
| url | https://www.bio-conferences.org/articles/bioconf/pdf/2024/05/bioconf_rtbs2024_01038.pdf |
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