Discordant Eosinophilic/T-Cell Chorionic Vasculitis in a Dichorionic Diamniotic Placenta
Eosinophilic/T-cell chorionic vasculitis (ETCV) is an idiopathic lesion composed of eosinophils, CD3+ T lymphocytes, and histiocytes. In twins, ETCV may affect only one chorionic plate, a feature defined as “discordant”. We present a case of ETCV discordance in a diamniotic dichorionic placenta at 3...
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MDPI AG
2023-05-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/11/9207 |
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| author | Evelina Silvestri Francesca Servadei Ione Tamagnini Laura Moretti Maria Paola Bonasoni |
| author_facet | Evelina Silvestri Francesca Servadei Ione Tamagnini Laura Moretti Maria Paola Bonasoni |
| author_sort | Evelina Silvestri |
| collection | DOAJ |
| description | Eosinophilic/T-cell chorionic vasculitis (ETCV) is an idiopathic lesion composed of eosinophils, CD3+ T lymphocytes, and histiocytes. In twins, ETCV may affect only one chorionic plate, a feature defined as “discordant”. We present a case of ETCV discordance in a diamniotic dichorionic placenta at 38 weeks of gestation, in which the female twin was small for gestational age, weighing 2670 g (25th percentile). The corresponding placental territory presented ETCV in two close chorionic vessels with concordance of the fetal inflammatory response. Immunohistochemistry showed an abundance of CD3+/CD4+/CD25+T lymphocytes, CD68 PG M1+ macrophages, and scattered CD8+ T cells with focal TIA-1 positivity. Granzyme B, CD20 B lymphocytes, and CD56 natural killer cells were negative. High-grade villitis of unknown etiology (VUE) was additionally found and displayed comparable ETCV findings, except for an equivalent ratio of CD4+/CD8+ T cells, but TIA-1 was focally expressed. VUE was associated with chronic histiocytic intervillositis (CHI). The combination of ETCV, VUE, and CHI may have been responsible for reduced fetal growth. Concordance was observed in the ETCV and TIA-1 expression, both in ETCV and in VUE, which is a maternal response. These findings may suggest a common antigen or chemokine pathway to which both mother and fetus accordingly responded. |
| first_indexed | 2024-03-11T03:06:45Z |
| format | Article |
| id | doaj.art-8a5d9629eb3847bfb77e25ed40d182da |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T03:06:45Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-8a5d9629eb3847bfb77e25ed40d182da2023-11-18T07:55:58ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-05-012411920710.3390/ijms24119207Discordant Eosinophilic/T-Cell Chorionic Vasculitis in a Dichorionic Diamniotic PlacentaEvelina Silvestri0Francesca Servadei1Ione Tamagnini2Laura Moretti3Maria Paola Bonasoni4Unit of Fetal and Neonatal Pathology, Division of Pathology, San Camillo-Forlanini Hospital, 00152 Rome, ItalyAnatomic Pathology, Department of Experimental Medicine, University of Rome “Tor Vergata”, 00133 Rome, ItalyPathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, ItalyPathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, ItalyPathology Unit, Azienda USL-IRCCS di Reggio Emilia, 42123 Reggio Emilia, ItalyEosinophilic/T-cell chorionic vasculitis (ETCV) is an idiopathic lesion composed of eosinophils, CD3+ T lymphocytes, and histiocytes. In twins, ETCV may affect only one chorionic plate, a feature defined as “discordant”. We present a case of ETCV discordance in a diamniotic dichorionic placenta at 38 weeks of gestation, in which the female twin was small for gestational age, weighing 2670 g (25th percentile). The corresponding placental territory presented ETCV in two close chorionic vessels with concordance of the fetal inflammatory response. Immunohistochemistry showed an abundance of CD3+/CD4+/CD25+T lymphocytes, CD68 PG M1+ macrophages, and scattered CD8+ T cells with focal TIA-1 positivity. Granzyme B, CD20 B lymphocytes, and CD56 natural killer cells were negative. High-grade villitis of unknown etiology (VUE) was additionally found and displayed comparable ETCV findings, except for an equivalent ratio of CD4+/CD8+ T cells, but TIA-1 was focally expressed. VUE was associated with chronic histiocytic intervillositis (CHI). The combination of ETCV, VUE, and CHI may have been responsible for reduced fetal growth. Concordance was observed in the ETCV and TIA-1 expression, both in ETCV and in VUE, which is a maternal response. These findings may suggest a common antigen or chemokine pathway to which both mother and fetus accordingly responded.https://www.mdpi.com/1422-0067/24/11/9207Eosinophilic/T-Cell chorionic vasculitistwin placentadiscordanceTIA-1 concordance |
| spellingShingle | Evelina Silvestri Francesca Servadei Ione Tamagnini Laura Moretti Maria Paola Bonasoni Discordant Eosinophilic/T-Cell Chorionic Vasculitis in a Dichorionic Diamniotic Placenta International Journal of Molecular Sciences Eosinophilic/T-Cell chorionic vasculitis twin placenta discordance TIA-1 concordance |
| title | Discordant Eosinophilic/T-Cell Chorionic Vasculitis in a Dichorionic Diamniotic Placenta |
| title_full | Discordant Eosinophilic/T-Cell Chorionic Vasculitis in a Dichorionic Diamniotic Placenta |
| title_fullStr | Discordant Eosinophilic/T-Cell Chorionic Vasculitis in a Dichorionic Diamniotic Placenta |
| title_full_unstemmed | Discordant Eosinophilic/T-Cell Chorionic Vasculitis in a Dichorionic Diamniotic Placenta |
| title_short | Discordant Eosinophilic/T-Cell Chorionic Vasculitis in a Dichorionic Diamniotic Placenta |
| title_sort | discordant eosinophilic t cell chorionic vasculitis in a dichorionic diamniotic placenta |
| topic | Eosinophilic/T-Cell chorionic vasculitis twin placenta discordance TIA-1 concordance |
| url | https://www.mdpi.com/1422-0067/24/11/9207 |
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