CT attenuation values of blood and myocardium: rationale for accurate coronary artery calcifications detection with multi-detector CT.
<h4>Objectives</h4>To determine inter-session and intra/inter-individual variations of the attenuations of aortic blood/myocardium with MDCT in the context of calcium scoring. To evaluate whether these variations are dependent on patients' characteristics.<h4>Methods</h4>...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0124175 |
| _version_ | 1819028769328857088 |
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| author | Salah D Qanadli Anne-Marie Jouannic Jamshid Dehmeshki Tri-Linh Lu |
| author_facet | Salah D Qanadli Anne-Marie Jouannic Jamshid Dehmeshki Tri-Linh Lu |
| author_sort | Salah D Qanadli |
| collection | DOAJ |
| description | <h4>Objectives</h4>To determine inter-session and intra/inter-individual variations of the attenuations of aortic blood/myocardium with MDCT in the context of calcium scoring. To evaluate whether these variations are dependent on patients' characteristics.<h4>Methods</h4>Fifty-four volunteers were evaluated with calcium scoring non-enhanced CT. We measured attenuations (inter-individual variation) and standard deviations (SD, intra-individual variation) of the blood in the ascending aorta and of the myocardium of left ventricle. Every volunteer was examined twice to study the inter-session variation. The fat pad thickness at the sternum and noise (SD of air) were measured too. These values were correlated with the measured aortic/ventricular attenuations and their SDs (Pearson). Historically fixed thresholds (90 and 130 HU) were tested against different models based on attenuations of blood/ventricle.<h4>Results</h4>The mean attenuation was 46 HU (range, 17-84 HU) with mean SD 23 HU for the blood, and 39 HU (10-82 HU) with mean SD 18 HU for the myocardium. The attenuation/SD of the blood were significantly higher than those of the myocardium (p < 0.01). The inter-session variation was not significant. There was a poor correlation between SD of aortic blood/ventricle with fat thickness/noise. Based on existing models, 90 HU threshold offers a confidence interval of approximately 95% and 130 HU more than 99%.<h4>Conclusions</h4>Historical thresholds offer high confidence intervals for exclusion of aortic blood/myocardium and by the way for detecting calcifications. Nevertheless, considering the large variations of blood/myocardium CT values and the influence of patient's characteristics, a better approach might be an adaptive threshold. |
| first_indexed | 2024-12-21T06:03:38Z |
| format | Article |
| id | doaj.art-8a5e9ddb3bae441d9c07fbbde5c8cfdd |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-21T06:03:38Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-8a5e9ddb3bae441d9c07fbbde5c8cfdd2022-12-21T19:13:42ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01104e012417510.1371/journal.pone.0124175CT attenuation values of blood and myocardium: rationale for accurate coronary artery calcifications detection with multi-detector CT.Salah D QanadliAnne-Marie JouannicJamshid DehmeshkiTri-Linh Lu<h4>Objectives</h4>To determine inter-session and intra/inter-individual variations of the attenuations of aortic blood/myocardium with MDCT in the context of calcium scoring. To evaluate whether these variations are dependent on patients' characteristics.<h4>Methods</h4>Fifty-four volunteers were evaluated with calcium scoring non-enhanced CT. We measured attenuations (inter-individual variation) and standard deviations (SD, intra-individual variation) of the blood in the ascending aorta and of the myocardium of left ventricle. Every volunteer was examined twice to study the inter-session variation. The fat pad thickness at the sternum and noise (SD of air) were measured too. These values were correlated with the measured aortic/ventricular attenuations and their SDs (Pearson). Historically fixed thresholds (90 and 130 HU) were tested against different models based on attenuations of blood/ventricle.<h4>Results</h4>The mean attenuation was 46 HU (range, 17-84 HU) with mean SD 23 HU for the blood, and 39 HU (10-82 HU) with mean SD 18 HU for the myocardium. The attenuation/SD of the blood were significantly higher than those of the myocardium (p < 0.01). The inter-session variation was not significant. There was a poor correlation between SD of aortic blood/ventricle with fat thickness/noise. Based on existing models, 90 HU threshold offers a confidence interval of approximately 95% and 130 HU more than 99%.<h4>Conclusions</h4>Historical thresholds offer high confidence intervals for exclusion of aortic blood/myocardium and by the way for detecting calcifications. Nevertheless, considering the large variations of blood/myocardium CT values and the influence of patient's characteristics, a better approach might be an adaptive threshold.https://doi.org/10.1371/journal.pone.0124175 |
| spellingShingle | Salah D Qanadli Anne-Marie Jouannic Jamshid Dehmeshki Tri-Linh Lu CT attenuation values of blood and myocardium: rationale for accurate coronary artery calcifications detection with multi-detector CT. PLoS ONE |
| title | CT attenuation values of blood and myocardium: rationale for accurate coronary artery calcifications detection with multi-detector CT. |
| title_full | CT attenuation values of blood and myocardium: rationale for accurate coronary artery calcifications detection with multi-detector CT. |
| title_fullStr | CT attenuation values of blood and myocardium: rationale for accurate coronary artery calcifications detection with multi-detector CT. |
| title_full_unstemmed | CT attenuation values of blood and myocardium: rationale for accurate coronary artery calcifications detection with multi-detector CT. |
| title_short | CT attenuation values of blood and myocardium: rationale for accurate coronary artery calcifications detection with multi-detector CT. |
| title_sort | ct attenuation values of blood and myocardium rationale for accurate coronary artery calcifications detection with multi detector ct |
| url | https://doi.org/10.1371/journal.pone.0124175 |
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