Anti-ulcer properties, cytokines, and apoptosis regulatory effects of Olea europaea leaves from Hail Province, Saudi Arabia
This study investigated the anti-ulcer properties of raw olive leaf powder (OLP) and its immunomodulatory potential through the cytokine network. The efficacy of OLP extract in treating stomach ulcers in rats in ethanol-induced models was examined using a single dosage (100, 200, 400 mg/kg) in grou...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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AcademicPres
2022-09-01
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| Series: | Notulae Botanicae Horti Agrobotanici Cluj-Napoca |
| Subjects: | |
| Online Access: | https://www.notulaebotanicae.ro/index.php/nbha/article/view/12891 |
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| author | Rahamat UNISSA Sivakumar S. MONI Humera BANU Sulafah S. ALRAHEF Sadeem S. ALRAHEF Taif K.M. ALENEZI Marwa H. ABDALLAH Amr S. ABU LILA Hemat EL-HORANY Amr S. ABOUZIED Siddig I. ABDELWAHAB Manal M.E. THAHA |
| author_facet | Rahamat UNISSA Sivakumar S. MONI Humera BANU Sulafah S. ALRAHEF Sadeem S. ALRAHEF Taif K.M. ALENEZI Marwa H. ABDALLAH Amr S. ABU LILA Hemat EL-HORANY Amr S. ABOUZIED Siddig I. ABDELWAHAB Manal M.E. THAHA |
| author_sort | Rahamat UNISSA |
| collection | DOAJ |
| description |
This study investigated the anti-ulcer properties of raw olive leaf powder (OLP) and its immunomodulatory potential through the cytokine network. The efficacy of OLP extract in treating stomach ulcers in rats in ethanol-induced models was examined using a single dosage (100, 200, 400 mg/kg) in groups 4, 5, and 6. The OLP demonstrated substantial anti-ulcer action even at 100 mg/kg. The activity was better at 400 mg/kg and almost equivalent to the conventional omeprazole treatment at 20 mg/kg in group 3. The cytokine network was studied in groups 1, 2, 3, and 6. The cytokine network was efficiently regulated by reducing the production of cytokines such as IL-1β, IL-2, IL-4, IL-6, IL-10, and TNF-α. The levels of caspase-3 and caspase-9 were also lowered in groups 3 and 4 considerably at p < 0.05. It is interesting to note that the expression of IFN was greater in animals treated with OLP in group 4, as compared to animals treated with omeprazole in group 3, as well as animals from the disease control group 2, when analyzed at a significance level of p < 0.05. The results revealed that OLP has intriguing potential for anti-ulcer action, and possesses immunomodulatory capabilities to control inflammatory cytokines and apoptotic markers.
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| first_indexed | 2024-12-10T04:44:16Z |
| format | Article |
| id | doaj.art-8a5f29016fdb42fd9a224fd8cf10eb25 |
| institution | Directory Open Access Journal |
| issn | 0255-965X 1842-4309 |
| language | English |
| last_indexed | 2024-12-10T04:44:16Z |
| publishDate | 2022-09-01 |
| publisher | AcademicPres |
| record_format | Article |
| series | Notulae Botanicae Horti Agrobotanici Cluj-Napoca |
| spelling | doaj.art-8a5f29016fdb42fd9a224fd8cf10eb252022-12-22T02:01:47ZengAcademicPresNotulae Botanicae Horti Agrobotanici Cluj-Napoca0255-965X1842-43092022-09-0150310.15835/nbha50312891Anti-ulcer properties, cytokines, and apoptosis regulatory effects of Olea europaea leaves from Hail Province, Saudi Arabia Rahamat UNISSA0Sivakumar S. MONI1Humera BANU2Sulafah S. ALRAHEF3Sadeem S. ALRAHEF4Taif K.M. ALENEZI5Marwa H. ABDALLAH6Amr S. ABU LILA7Hemat EL-HORANY8Amr S. ABOUZIED9Siddig I. ABDELWAHAB10Manal M.E. THAHA11University of Hail, College of Pharmacy, Department of Pharmaceutics, Hail, 81442Jazan University, Department of Pharmaceutics, College of Pharmacy, Jazan, 45142University of Hail, College of Applied Medical Sciences, Department of Clinical Nutrition, Hail, 81442University of Hail, College of Pharmacy, Hail, 81442University of Hail, College of Pharmacy, Hail, 81442University of Hail, College of Pharmacy, Hail, 81442University of Hail, College of Pharmacy, Department of Pharmaceutics, Hail, 81442; Zagazig University, Faculty of Pharmacy, Department of Pharmaceutics and Industrial Pharmacy, ZagazigUniversity of Hail, College of Pharmacy, Department of Pharmaceutics, Hail, 81442; Zagazig University, Faculty of Pharmacy, Department of Pharmaceutics and Industrial Pharmacy, ZagazigUniversity of Hail, College of Medicine, Department of Biochemistry, Hail, 81442; Tanta University, Department of Medical Biochemistry, Faculty of MedicineUniversity of Hail, College of Pharmacy, Department of Pharmaceutical Chemistry, Hail, 81442; National Organization for Drug Control and Research, Department of Pharmaceutical Chemistry, GizaJazan University, Medical Research Center, Jazan, 45142Jazan University, Substance Abuse and Toxicology Research Centre, Jazan, 45142 This study investigated the anti-ulcer properties of raw olive leaf powder (OLP) and its immunomodulatory potential through the cytokine network. The efficacy of OLP extract in treating stomach ulcers in rats in ethanol-induced models was examined using a single dosage (100, 200, 400 mg/kg) in groups 4, 5, and 6. The OLP demonstrated substantial anti-ulcer action even at 100 mg/kg. The activity was better at 400 mg/kg and almost equivalent to the conventional omeprazole treatment at 20 mg/kg in group 3. The cytokine network was studied in groups 1, 2, 3, and 6. The cytokine network was efficiently regulated by reducing the production of cytokines such as IL-1β, IL-2, IL-4, IL-6, IL-10, and TNF-α. The levels of caspase-3 and caspase-9 were also lowered in groups 3 and 4 considerably at p < 0.05. It is interesting to note that the expression of IFN was greater in animals treated with OLP in group 4, as compared to animals treated with omeprazole in group 3, as well as animals from the disease control group 2, when analyzed at a significance level of p < 0.05. The results revealed that OLP has intriguing potential for anti-ulcer action, and possesses immunomodulatory capabilities to control inflammatory cytokines and apoptotic markers. https://www.notulaebotanicae.ro/index.php/nbha/article/view/12891anti-ulcer activityapoptosis markerscytokine networkolive leavesraw powder |
| spellingShingle | Rahamat UNISSA Sivakumar S. MONI Humera BANU Sulafah S. ALRAHEF Sadeem S. ALRAHEF Taif K.M. ALENEZI Marwa H. ABDALLAH Amr S. ABU LILA Hemat EL-HORANY Amr S. ABOUZIED Siddig I. ABDELWAHAB Manal M.E. THAHA Anti-ulcer properties, cytokines, and apoptosis regulatory effects of Olea europaea leaves from Hail Province, Saudi Arabia Notulae Botanicae Horti Agrobotanici Cluj-Napoca anti-ulcer activity apoptosis markers cytokine network olive leaves raw powder |
| title | Anti-ulcer properties, cytokines, and apoptosis regulatory effects of Olea europaea leaves from Hail Province, Saudi Arabia |
| title_full | Anti-ulcer properties, cytokines, and apoptosis regulatory effects of Olea europaea leaves from Hail Province, Saudi Arabia |
| title_fullStr | Anti-ulcer properties, cytokines, and apoptosis regulatory effects of Olea europaea leaves from Hail Province, Saudi Arabia |
| title_full_unstemmed | Anti-ulcer properties, cytokines, and apoptosis regulatory effects of Olea europaea leaves from Hail Province, Saudi Arabia |
| title_short | Anti-ulcer properties, cytokines, and apoptosis regulatory effects of Olea europaea leaves from Hail Province, Saudi Arabia |
| title_sort | anti ulcer properties cytokines and apoptosis regulatory effects of olea europaea leaves from hail province saudi arabia |
| topic | anti-ulcer activity apoptosis markers cytokine network olive leaves raw powder |
| url | https://www.notulaebotanicae.ro/index.php/nbha/article/view/12891 |
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