The Contribution of Hippocampal All-Trans Retinoic Acid (ATRA) Deficiency to Alzheimer’s Disease: A Narrative Overview of ATRA-Dependent Gene Expression in Post-Mortem Hippocampal Tissue

The Contribution of Hippocampal All-Trans Retinoic Acid (ATRA) Deficiency to Alzheimer’s Disease: A Narrative Overview of ATRA-Dependent Gene Expression in Post-Mortem Hippocampal Tissue

There is accumulating evidence that vitamin A (VA) deficiency contributes to the pathogenesis and progression of Alzheimer’s disease (AD). All-<i>trans</i> retinoic acid (ATRA), a metabolite of VA in the brain, serves distinct roles in the human hippocampus. Agonists of retinoic acid rec...

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Bibliographic Details
Main Authors: Joey Almaguer, Ashly Hindle, J. Josh Lawrence
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Antioxidants
Subjects:
retinoic acid
vitamin A
Alzheimer’s disease
aging
Online Access:https://www.mdpi.com/2076-3921/12/11/1921

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