New Physico-Chemical Analysis of Magnesium-Doped Hydroxyapatite in Dextran Matrix Nanocomposites
The new magnesium-doped hydroxyapatite in dextran matrix (10MgHApD) nanocomposites were synthesized using coprecipitation technique. A spherical morphology was observed by scanning electron microscopy (SEM). The X-ray diffraction (XRD) characterization results show hydroxyapatite hexagonal phase for...
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MDPI AG
2023-12-01
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| Series: | Polymers |
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| Online Access: | https://www.mdpi.com/2073-4360/16/1/125 |
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| author | Daniela Predoi Steluta Carmen Ciobanu Simona Liliana Iconaru Ştefan Ţălu Liliana Ghegoiu Robert Saraiva Matos Henrique Duarte da Fonseca Filho Roxana Trusca |
| author_facet | Daniela Predoi Steluta Carmen Ciobanu Simona Liliana Iconaru Ştefan Ţălu Liliana Ghegoiu Robert Saraiva Matos Henrique Duarte da Fonseca Filho Roxana Trusca |
| author_sort | Daniela Predoi |
| collection | DOAJ |
| description | The new magnesium-doped hydroxyapatite in dextran matrix (10MgHApD) nanocomposites were synthesized using coprecipitation technique. A spherical morphology was observed by scanning electron microscopy (SEM). The X-ray diffraction (XRD) characterization results show hydroxyapatite hexagonal phase formation. The element map scanning during the EDS analysis revealed homogenous distribution of constituent elements of calcium, phosphor, oxygen and magnesium. The presence of dextran in the sample was revealed by Fourier transform infrared (FTIR) spectroscopy. The antimicrobial activity of the 10MgHAPD nanocomposites was assessed by in vitro assays using <i>Staphylococcus aureus</i> ATCC 25923, <i>Pseudomonas aeruginosa</i> ATCC 27853, <i>Streptococcus mutans</i> ATCC 25175, <i>Porphyromonas gingivalis</i> ATCC 33277 and <i>Candida albicans</i> ATCC 10231 microbial strains. The results of the antimicrobial assays highlighted that the 10MgHApD nanocomposites presented excellent antimicrobial activity against all the tested microorganisms and for all the tested time intervals. Furthermore, the biocompatibility assays determined that the 10MgHApD nanocomposites did not exhibit any toxicity towards Human gingival fibroblast (HGF-1) cells. |
| first_indexed | 2024-03-08T14:59:28Z |
| format | Article |
| id | doaj.art-8a60e2fc639a4406b22f66a1f6a45aee |
| institution | Directory Open Access Journal |
| issn | 2073-4360 |
| language | English |
| last_indexed | 2024-03-08T14:59:28Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Polymers |
| spelling | doaj.art-8a60e2fc639a4406b22f66a1f6a45aee2024-01-10T15:06:55ZengMDPI AGPolymers2073-43602023-12-0116112510.3390/polym16010125New Physico-Chemical Analysis of Magnesium-Doped Hydroxyapatite in Dextran Matrix NanocompositesDaniela Predoi0Steluta Carmen Ciobanu1Simona Liliana Iconaru2Ştefan Ţălu3Liliana Ghegoiu4Robert Saraiva Matos5Henrique Duarte da Fonseca Filho6Roxana Trusca7National Institute of Materials Physics, Atomistilor Street, No. 405A, P.O. Box MG 07, 077125 Magurele, RomaniaNational Institute of Materials Physics, Atomistilor Street, No. 405A, P.O. Box MG 07, 077125 Magurele, RomaniaNational Institute of Materials Physics, Atomistilor Street, No. 405A, P.O. Box MG 07, 077125 Magurele, RomaniaThe Directorate of Research, Development and Innovation Management (DMCDI), Technical University of Cluj-Napoca, 15 Constantin Daicoviciu St., 400020 Cluj-Napoca, RomaniaNational Institute of Materials Physics, Atomistilor Street, No. 405A, P.O. Box MG 07, 077125 Magurele, RomaniaAmazonian Materials Group, Physics Department, Federal University of Amapá (UNIFAP), Macapá 68903-419, Amapá, BrazilLaboratory of Synthesis of Nanomaterials and Nanoscopy (LSNN), Physics Department, Federal University of Amazonas-UFAM, Manaus 69067-005, Amazonas, BrazilNational Centre for Micro and Nanomaterials, University Politehnica of Bucharest, 060042 Bucharest, RomaniaThe new magnesium-doped hydroxyapatite in dextran matrix (10MgHApD) nanocomposites were synthesized using coprecipitation technique. A spherical morphology was observed by scanning electron microscopy (SEM). The X-ray diffraction (XRD) characterization results show hydroxyapatite hexagonal phase formation. The element map scanning during the EDS analysis revealed homogenous distribution of constituent elements of calcium, phosphor, oxygen and magnesium. The presence of dextran in the sample was revealed by Fourier transform infrared (FTIR) spectroscopy. The antimicrobial activity of the 10MgHAPD nanocomposites was assessed by in vitro assays using <i>Staphylococcus aureus</i> ATCC 25923, <i>Pseudomonas aeruginosa</i> ATCC 27853, <i>Streptococcus mutans</i> ATCC 25175, <i>Porphyromonas gingivalis</i> ATCC 33277 and <i>Candida albicans</i> ATCC 10231 microbial strains. The results of the antimicrobial assays highlighted that the 10MgHApD nanocomposites presented excellent antimicrobial activity against all the tested microorganisms and for all the tested time intervals. Furthermore, the biocompatibility assays determined that the 10MgHApD nanocomposites did not exhibit any toxicity towards Human gingival fibroblast (HGF-1) cells.https://www.mdpi.com/2073-4360/16/1/125biomedical applicationsdextranfractal featureshydroxyapatitemagnesium |
| spellingShingle | Daniela Predoi Steluta Carmen Ciobanu Simona Liliana Iconaru Ştefan Ţălu Liliana Ghegoiu Robert Saraiva Matos Henrique Duarte da Fonseca Filho Roxana Trusca New Physico-Chemical Analysis of Magnesium-Doped Hydroxyapatite in Dextran Matrix Nanocomposites Polymers biomedical applications dextran fractal features hydroxyapatite magnesium |
| title | New Physico-Chemical Analysis of Magnesium-Doped Hydroxyapatite in Dextran Matrix Nanocomposites |
| title_full | New Physico-Chemical Analysis of Magnesium-Doped Hydroxyapatite in Dextran Matrix Nanocomposites |
| title_fullStr | New Physico-Chemical Analysis of Magnesium-Doped Hydroxyapatite in Dextran Matrix Nanocomposites |
| title_full_unstemmed | New Physico-Chemical Analysis of Magnesium-Doped Hydroxyapatite in Dextran Matrix Nanocomposites |
| title_short | New Physico-Chemical Analysis of Magnesium-Doped Hydroxyapatite in Dextran Matrix Nanocomposites |
| title_sort | new physico chemical analysis of magnesium doped hydroxyapatite in dextran matrix nanocomposites |
| topic | biomedical applications dextran fractal features hydroxyapatite magnesium |
| url | https://www.mdpi.com/2073-4360/16/1/125 |
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