The trafficking and targeting of P2X receptors
The functional expression of P2X receptors at the plasma membrane is dependent on their trafficking along secretory and endocytic pathways. There are seven P2X receptor subunits, and these differ in their subcellular distributions because they have very different trafficking properties. Some are ret...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-11-01
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| Series: | Frontiers in Cellular Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00233/full |
| _version_ | 1819261796165353472 |
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| author | Ruth Dorothy Murrell-Lagnado Lucy Elizabeth Robinson |
| author_facet | Ruth Dorothy Murrell-Lagnado Lucy Elizabeth Robinson |
| author_sort | Ruth Dorothy Murrell-Lagnado |
| collection | DOAJ |
| description | The functional expression of P2X receptors at the plasma membrane is dependent on their trafficking along secretory and endocytic pathways. There are seven P2X receptor subunits, and these differ in their subcellular distributions because they have very different trafficking properties. Some are retained within the endoplasmic reticulum (ER), while others are predominantly at the cell surface or within endosomes and lysosomes. Changes in recruitment of receptors to and from the plasma membrane provides a way of rapidly up- or down-regulating the cellular response to ATP. An additional layer of regulation is the targeting of these receptors within the membranes of each compartment, which affects their stability, function and the nature of the effector proteins with which they form signaling complexes. The trafficking and targeting of P2X receptors is regulated by their interactions with other proteins and with lipids and we can expect this to vary in a cell-type specific manner, giving rise to differences in receptor activity and function. |
| first_indexed | 2024-12-23T19:47:29Z |
| format | Article |
| id | doaj.art-8a6134e8cffe49e6a77629c85c65f08e |
| institution | Directory Open Access Journal |
| issn | 1662-5102 |
| language | English |
| last_indexed | 2024-12-23T19:47:29Z |
| publishDate | 2013-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular Neuroscience |
| spelling | doaj.art-8a6134e8cffe49e6a77629c85c65f08e2022-12-21T17:33:29ZengFrontiers Media S.A.Frontiers in Cellular Neuroscience1662-51022013-11-01710.3389/fncel.2013.0023370900The trafficking and targeting of P2X receptorsRuth Dorothy Murrell-Lagnado0Lucy Elizabeth Robinson1University of CambridgeUniversity of CambridgeThe functional expression of P2X receptors at the plasma membrane is dependent on their trafficking along secretory and endocytic pathways. There are seven P2X receptor subunits, and these differ in their subcellular distributions because they have very different trafficking properties. Some are retained within the endoplasmic reticulum (ER), while others are predominantly at the cell surface or within endosomes and lysosomes. Changes in recruitment of receptors to and from the plasma membrane provides a way of rapidly up- or down-regulating the cellular response to ATP. An additional layer of regulation is the targeting of these receptors within the membranes of each compartment, which affects their stability, function and the nature of the effector proteins with which they form signaling complexes. The trafficking and targeting of P2X receptors is regulated by their interactions with other proteins and with lipids and we can expect this to vary in a cell-type specific manner, giving rise to differences in receptor activity and function.http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00233/fulllipid raftsP2X receptor traffickingreceptor endocytosisreceptor regulationP2X receptor targeting |
| spellingShingle | Ruth Dorothy Murrell-Lagnado Lucy Elizabeth Robinson The trafficking and targeting of P2X receptors Frontiers in Cellular Neuroscience lipid rafts P2X receptor trafficking receptor endocytosis receptor regulation P2X receptor targeting |
| title | The trafficking and targeting of P2X receptors |
| title_full | The trafficking and targeting of P2X receptors |
| title_fullStr | The trafficking and targeting of P2X receptors |
| title_full_unstemmed | The trafficking and targeting of P2X receptors |
| title_short | The trafficking and targeting of P2X receptors |
| title_sort | trafficking and targeting of p2x receptors |
| topic | lipid rafts P2X receptor trafficking receptor endocytosis receptor regulation P2X receptor targeting |
| url | http://journal.frontiersin.org/Journal/10.3389/fncel.2013.00233/full |
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