A Review of Immunotherapeutic Strategies in Canine Malignant Melanoma
In dogs, melanomas are relatively common tumors and the most common form of oral malignancy. Biological behavior is highly variable, usually aggressive, and frequently metastatic, with reported survival times of three months for oral or mucosal melanomas in advanced disease stages. Classical clinica...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2019-02-01
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| Series: | Veterinary Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2306-7381/6/1/15 |
| _version_ | 1818347672106434560 |
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| author | Ramón M. Almela Agustina Ansón |
| author_facet | Ramón M. Almela Agustina Ansón |
| author_sort | Ramón M. Almela |
| collection | DOAJ |
| description | In dogs, melanomas are relatively common tumors and the most common form of oral malignancy. Biological behavior is highly variable, usually aggressive, and frequently metastatic, with reported survival times of three months for oral or mucosal melanomas in advanced disease stages. Classical clinical management remains challenging; thus, novel and more efficacious treatment strategies are needed. Evidence-based medicine supports the role of the immune system to treat neoplastic diseases. Besides, immunotherapy offers the possibility of a precise medicinal approach to treat cancer. In recent years, multiple immunotherapeutic strategies have been developed, and are now recognized as a pillar of treatment. In addition, dogs represent a good model for translational medicine purposes. This review will cover the most relevant immunotherapeutic strategies for the treatment of canine malignant melanoma, divided among five different categories, namely, monoclonal antibodies, nonspecific immunotherapy activated by bacteria, vaccines, gene therapy, and lymphokine-activated killer cell therapy. |
| first_indexed | 2024-12-13T17:37:53Z |
| format | Article |
| id | doaj.art-8a61be7635464c26a7fa1b879e8e45f2 |
| institution | Directory Open Access Journal |
| issn | 2306-7381 |
| language | English |
| last_indexed | 2024-12-13T17:37:53Z |
| publishDate | 2019-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Veterinary Sciences |
| spelling | doaj.art-8a61be7635464c26a7fa1b879e8e45f22022-12-21T23:36:52ZengMDPI AGVeterinary Sciences2306-73812019-02-01611510.3390/vetsci6010015vetsci6010015A Review of Immunotherapeutic Strategies in Canine Malignant MelanomaRamón M. Almela0Agustina Ansón1Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, Grafton, MA 01536, USADepartment of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, Grafton, MA 01536, USAIn dogs, melanomas are relatively common tumors and the most common form of oral malignancy. Biological behavior is highly variable, usually aggressive, and frequently metastatic, with reported survival times of three months for oral or mucosal melanomas in advanced disease stages. Classical clinical management remains challenging; thus, novel and more efficacious treatment strategies are needed. Evidence-based medicine supports the role of the immune system to treat neoplastic diseases. Besides, immunotherapy offers the possibility of a precise medicinal approach to treat cancer. In recent years, multiple immunotherapeutic strategies have been developed, and are now recognized as a pillar of treatment. In addition, dogs represent a good model for translational medicine purposes. This review will cover the most relevant immunotherapeutic strategies for the treatment of canine malignant melanoma, divided among five different categories, namely, monoclonal antibodies, nonspecific immunotherapy activated by bacteria, vaccines, gene therapy, and lymphokine-activated killer cell therapy.https://www.mdpi.com/2306-7381/6/1/15melanomamalignantcanineimmunotherapyvaccinegene therapyreview |
| spellingShingle | Ramón M. Almela Agustina Ansón A Review of Immunotherapeutic Strategies in Canine Malignant Melanoma Veterinary Sciences melanoma malignant canine immunotherapy vaccine gene therapy review |
| title | A Review of Immunotherapeutic Strategies in Canine Malignant Melanoma |
| title_full | A Review of Immunotherapeutic Strategies in Canine Malignant Melanoma |
| title_fullStr | A Review of Immunotherapeutic Strategies in Canine Malignant Melanoma |
| title_full_unstemmed | A Review of Immunotherapeutic Strategies in Canine Malignant Melanoma |
| title_short | A Review of Immunotherapeutic Strategies in Canine Malignant Melanoma |
| title_sort | review of immunotherapeutic strategies in canine malignant melanoma |
| topic | melanoma malignant canine immunotherapy vaccine gene therapy review |
| url | https://www.mdpi.com/2306-7381/6/1/15 |
| work_keys_str_mv | AT ramonmalmela areviewofimmunotherapeuticstrategiesincaninemalignantmelanoma AT agustinaanson areviewofimmunotherapeuticstrategiesincaninemalignantmelanoma AT ramonmalmela reviewofimmunotherapeuticstrategiesincaninemalignantmelanoma AT agustinaanson reviewofimmunotherapeuticstrategiesincaninemalignantmelanoma |