Dynamic alterations in decoy VEGF receptor-1 stability regulate angiogenesis
Membrane-bound mVEGFR1 is a decoy VEGF-A receptor that regulates VEGF-A signalling amplitude. Boucheret al. show that Rab27a-regulated palmitoylation of mVEGFR1 redirects the receptor from a stable, constitutively recycling mode to a degradative route that removes ligands from the system.
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-06-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms15699 |
| _version_ | 1828977753374851072 |
|---|---|
| author | Joshua M. Boucher Ryan P. Clark Diana C. Chong Kathryn M. Citrin Lyndsay A. Wylie Victoria L. Bautch |
| author_facet | Joshua M. Boucher Ryan P. Clark Diana C. Chong Kathryn M. Citrin Lyndsay A. Wylie Victoria L. Bautch |
| author_sort | Joshua M. Boucher |
| collection | DOAJ |
| description | Membrane-bound mVEGFR1 is a decoy VEGF-A receptor that regulates VEGF-A signalling amplitude. Boucheret al. show that Rab27a-regulated palmitoylation of mVEGFR1 redirects the receptor from a stable, constitutively recycling mode to a degradative route that removes ligands from the system. |
| first_indexed | 2024-12-14T15:05:27Z |
| format | Article |
| id | doaj.art-8a6449f75bca4d14bde1f8777d50adc4 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T15:05:27Z |
| publishDate | 2017-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-8a6449f75bca4d14bde1f8777d50adc42022-12-21T22:56:43ZengNature PortfolioNature Communications2041-17232017-06-018111510.1038/ncomms15699Dynamic alterations in decoy VEGF receptor-1 stability regulate angiogenesisJoshua M. Boucher0Ryan P. Clark1Diana C. Chong2Kathryn M. Citrin3Lyndsay A. Wylie4Victoria L. Bautch5Department of Biology, University of North Carolina at Chapel HillDepartment of Biology, University of North Carolina at Chapel HillGenetics and Molecular Biology Curriculum, University of North Carolina at Chapel HillDepartment of Biology, University of North Carolina at Chapel HillGenetics and Molecular Biology Curriculum, University of North Carolina at Chapel HillDepartment of Biology, University of North Carolina at Chapel HillMembrane-bound mVEGFR1 is a decoy VEGF-A receptor that regulates VEGF-A signalling amplitude. Boucheret al. show that Rab27a-regulated palmitoylation of mVEGFR1 redirects the receptor from a stable, constitutively recycling mode to a degradative route that removes ligands from the system.https://doi.org/10.1038/ncomms15699 |
| spellingShingle | Joshua M. Boucher Ryan P. Clark Diana C. Chong Kathryn M. Citrin Lyndsay A. Wylie Victoria L. Bautch Dynamic alterations in decoy VEGF receptor-1 stability regulate angiogenesis Nature Communications |
| title | Dynamic alterations in decoy VEGF receptor-1 stability regulate angiogenesis |
| title_full | Dynamic alterations in decoy VEGF receptor-1 stability regulate angiogenesis |
| title_fullStr | Dynamic alterations in decoy VEGF receptor-1 stability regulate angiogenesis |
| title_full_unstemmed | Dynamic alterations in decoy VEGF receptor-1 stability regulate angiogenesis |
| title_short | Dynamic alterations in decoy VEGF receptor-1 stability regulate angiogenesis |
| title_sort | dynamic alterations in decoy vegf receptor 1 stability regulate angiogenesis |
| url | https://doi.org/10.1038/ncomms15699 |
| work_keys_str_mv | AT joshuamboucher dynamicalterationsindecoyvegfreceptor1stabilityregulateangiogenesis AT ryanpclark dynamicalterationsindecoyvegfreceptor1stabilityregulateangiogenesis AT dianacchong dynamicalterationsindecoyvegfreceptor1stabilityregulateangiogenesis AT kathrynmcitrin dynamicalterationsindecoyvegfreceptor1stabilityregulateangiogenesis AT lyndsayawylie dynamicalterationsindecoyvegfreceptor1stabilityregulateangiogenesis AT victorialbautch dynamicalterationsindecoyvegfreceptor1stabilityregulateangiogenesis |