Efficacy of one drop of 2% pilocarpine to reverse the intraocular pressure peak at 6:00 a.m. in early glaucoma
Purpose: To assess the efficacy of one drop of 2% pilocarpine (2% Pi) at night to reverse the intraocular pressure (IOP) peak at 6:00 a.m. in the daily curve of intraocular pressure (DCPo) of pre-perimetric open-angle glaucoma. Methods: We retrospectively analyzed the charts of patients with early...
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| Format: | Article |
| Language: | English |
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Pan-American Association of Ophthalmology
2012-03-01
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| Series: | Vision Pan-America |
| Subjects: | |
| Online Access: | http://journals.sfu.ca/paao/index.php/journal/article/view/19 |
| _version_ | 1818651961040306176 |
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| author | Sebastião Cronemberger Nassim Calixto Marcelo Nacif Moraes Iuri David Castro Patrícia Cordeiro Lana Artur Furst Loredo |
| author_facet | Sebastião Cronemberger Nassim Calixto Marcelo Nacif Moraes Iuri David Castro Patrícia Cordeiro Lana Artur Furst Loredo |
| author_sort | Sebastião Cronemberger |
| collection | DOAJ |
| description | Purpose: To assess the efficacy of one drop of 2% pilocarpine (2% Pi) at night to reverse the intraocular pressure (IOP) peak at 6:00 a.m. in the daily curve of intraocular pressure (DCPo) of pre-perimetric open-angle glaucoma.
Methods: We retrospectively analyzed the charts of patients with early glaucoma. We compared the IOP values at 6:00 a.m. in the same eye of two DCPos. In the first DCPo the patients were without medication, and in the second they were using one drop of 2% Pi between 10:00 and 10:30 p.m. for at least six months. Each DCPo had five IOP measurements taken at 9:00 a.m., 12:00, 6:00 and 10:00 p.m. (Goldmann applanation tonometer) and in the morning of the following day at 06:00 a.m. (Perkins tonometer) in a supine position in bed and in darkness before the patient had stood up. The pre-perimetric glaucoma patients, without medication, presented an IOP peak at 6:00 a.m. in the DCPo. This peak represents a difference ≥7 mmHg between the IOP value at 6:00 a.m. and that lesser IOP at any other time in the DCPo. An IOP peak reversion at 6:00 a.m under 2% Pi occurred when the difference between the IOP at 6:00 a.m. and the lesser IOP was ≤5 mmHg in the DCPo. Patients with secondary glaucoma were excluded. We set the significance level at 5% (P<0.05).
Results: Sixty-one eyes of 35 patients with average age of 56.1 years were included. Under 2% Pi the IOP peak at 6:00 a.m. reversed significantly (X2=7.96; P=0.005) in 44 (72.1%) eyes. The mean IOP dropped from 22.1±2.3 mmHg in the DCPo without medication to 16.8±2.7 mmHg in the DCPo under 2% Pi (t=7.9; P<0.001).
Conclusion: One drop of 2% Pi at night is effective to reverse the IOP peak at 6:00 a.m. in pre-perimetric glaucoma. |
| first_indexed | 2024-12-17T02:14:25Z |
| format | Article |
| id | doaj.art-8a66d33dce404d549f1182da165d834e |
| institution | Directory Open Access Journal |
| issn | 2219-4665 2219-4673 |
| language | English |
| last_indexed | 2024-12-17T02:14:25Z |
| publishDate | 2012-03-01 |
| publisher | Pan-American Association of Ophthalmology |
| record_format | Article |
| series | Vision Pan-America |
| spelling | doaj.art-8a66d33dce404d549f1182da165d834e2022-12-21T22:07:27ZengPan-American Association of OphthalmologyVision Pan-America2219-46652219-46732012-03-01111141610.15324/vpa.v11i1.194Efficacy of one drop of 2% pilocarpine to reverse the intraocular pressure peak at 6:00 a.m. in early glaucomaSebastião Cronemberger0Nassim Calixto1Marcelo Nacif Moraes2Iuri David Castro3Patrícia Cordeiro Lana4Artur Furst Loredo5Federal University of Minas GeraisFederal University of Minas GeraisFederal University of Minas GeraisFederal University of Minas GeraisFederal University of Minas GeraisFederal University of Minas GeraisPurpose: To assess the efficacy of one drop of 2% pilocarpine (2% Pi) at night to reverse the intraocular pressure (IOP) peak at 6:00 a.m. in the daily curve of intraocular pressure (DCPo) of pre-perimetric open-angle glaucoma. Methods: We retrospectively analyzed the charts of patients with early glaucoma. We compared the IOP values at 6:00 a.m. in the same eye of two DCPos. In the first DCPo the patients were without medication, and in the second they were using one drop of 2% Pi between 10:00 and 10:30 p.m. for at least six months. Each DCPo had five IOP measurements taken at 9:00 a.m., 12:00, 6:00 and 10:00 p.m. (Goldmann applanation tonometer) and in the morning of the following day at 06:00 a.m. (Perkins tonometer) in a supine position in bed and in darkness before the patient had stood up. The pre-perimetric glaucoma patients, without medication, presented an IOP peak at 6:00 a.m. in the DCPo. This peak represents a difference ≥7 mmHg between the IOP value at 6:00 a.m. and that lesser IOP at any other time in the DCPo. An IOP peak reversion at 6:00 a.m under 2% Pi occurred when the difference between the IOP at 6:00 a.m. and the lesser IOP was ≤5 mmHg in the DCPo. Patients with secondary glaucoma were excluded. We set the significance level at 5% (P<0.05). Results: Sixty-one eyes of 35 patients with average age of 56.1 years were included. Under 2% Pi the IOP peak at 6:00 a.m. reversed significantly (X2=7.96; P=0.005) in 44 (72.1%) eyes. The mean IOP dropped from 22.1±2.3 mmHg in the DCPo without medication to 16.8±2.7 mmHg in the DCPo under 2% Pi (t=7.9; P<0.001). Conclusion: One drop of 2% Pi at night is effective to reverse the IOP peak at 6:00 a.m. in pre-perimetric glaucoma.http://journals.sfu.ca/paao/index.php/journal/article/view/19intraocular pressurepilocarpineefficacy. |
| spellingShingle | Sebastião Cronemberger Nassim Calixto Marcelo Nacif Moraes Iuri David Castro Patrícia Cordeiro Lana Artur Furst Loredo Efficacy of one drop of 2% pilocarpine to reverse the intraocular pressure peak at 6:00 a.m. in early glaucoma Vision Pan-America intraocular pressure pilocarpine efficacy. |
| title | Efficacy of one drop of 2% pilocarpine to reverse the intraocular pressure peak at 6:00 a.m. in early glaucoma |
| title_full | Efficacy of one drop of 2% pilocarpine to reverse the intraocular pressure peak at 6:00 a.m. in early glaucoma |
| title_fullStr | Efficacy of one drop of 2% pilocarpine to reverse the intraocular pressure peak at 6:00 a.m. in early glaucoma |
| title_full_unstemmed | Efficacy of one drop of 2% pilocarpine to reverse the intraocular pressure peak at 6:00 a.m. in early glaucoma |
| title_short | Efficacy of one drop of 2% pilocarpine to reverse the intraocular pressure peak at 6:00 a.m. in early glaucoma |
| title_sort | efficacy of one drop of 2 pilocarpine to reverse the intraocular pressure peak at 6 00 a m in early glaucoma |
| topic | intraocular pressure pilocarpine efficacy. |
| url | http://journals.sfu.ca/paao/index.php/journal/article/view/19 |
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