Longitudinal Analysis of 1α,25-dihidroxyvitamin D<sub>3</sub> and Homocysteine Changes in Colorectal Cancer
Background: 1α,25-dihydroxycholecalciferol (1,25(OH)<sub>2</sub>D<sub>3</sub>) and homocysteine are known to play a role in the pathophysiology of colorectal cancer (CRC). In health, the two changes are inversely proportional to each other, but little is known about their com...
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| Format: | Article |
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MDPI AG
2022-01-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/3/658 |
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| author | Dorottya Mühl Magdolna Herold Zoltan Herold Lilla Hornyák Attila Marcell Szasz Magdolna Dank |
| author_facet | Dorottya Mühl Magdolna Herold Zoltan Herold Lilla Hornyák Attila Marcell Szasz Magdolna Dank |
| author_sort | Dorottya Mühl |
| collection | DOAJ |
| description | Background: 1α,25-dihydroxycholecalciferol (1,25(OH)<sub>2</sub>D<sub>3</sub>) and homocysteine are known to play a role in the pathophysiology of colorectal cancer (CRC). In health, the two changes are inversely proportional to each other, but little is known about their combined effect in CRC. Methods: The serum 1,25(OH)<sub>2</sub>D<sub>3</sub> and the homocysteine levels of eighty-six CRC patients were measured, who were enrolled into four cohorts based on the presence of metastases (Adj vs. Met) and vitamin D<sub>3</sub> supplementation (ND vs. D). Results: 1,25(OH)<sub>2</sub>D<sub>3</sub> was constant (Adj-ND), increased significantly (Adj-D, <i>p</i> = 0.0261), decreased (Met-ND), or returned close to the baseline after an initial increase (Met-D). The longitudinal increase in 1,25(OH)<sub>2</sub>D<sub>3</sub> (HR: 0.9130, <i>p</i> = 0.0111) positively affected the overall survival in non-metastatic CRC, however, this effect was cancelled out in those with metastasis (<i>p</i> = 0.0107). The increase in homocysteine negatively affected both the overall (HR: 1.0940, <i>p</i> = 0.0067) and the progression-free survival (HR: 1.0845, <i>p</i> = 0.0073). Lower 1,25(OH)<sub>2</sub>D<sub>3</sub> and/or higher homocysteine level was characteristic for patients with higher serum lipids, albumin, total protein, white blood cell and platelet count, male sex, and right-sided tumors. No statistically justifiable connection was found between the target variables. Conclusions: A measurement-based titration of vitamin D<sub>3</sub> supplementation and better management of comorbidities are recommended for CRC. |
| first_indexed | 2024-03-10T00:07:19Z |
| format | Article |
| id | doaj.art-8a67903ce893467dadf28937b69c6a36 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T00:07:19Z |
| publishDate | 2022-01-01 |
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| record_format | Article |
| series | Cancers |
| spelling | doaj.art-8a67903ce893467dadf28937b69c6a362023-11-23T16:06:33ZengMDPI AGCancers2072-66942022-01-0114365810.3390/cancers14030658Longitudinal Analysis of 1α,25-dihidroxyvitamin D<sub>3</sub> and Homocysteine Changes in Colorectal CancerDorottya Mühl0Magdolna Herold1Zoltan Herold2Lilla Hornyák3Attila Marcell Szasz4Magdolna Dank5Division of Oncology, Department of Internal Medicine and Oncology, Semmelweis University, 1083 Budapest, HungaryDepartment of Internal Medicine and Hematology, Semmelweis University, 1088 Budapest, HungaryDivision of Oncology, Department of Internal Medicine and Oncology, Semmelweis University, 1083 Budapest, HungaryDivision of Oncology, Department of Internal Medicine and Oncology, Semmelweis University, 1083 Budapest, HungaryDivision of Oncology, Department of Internal Medicine and Oncology, Semmelweis University, 1083 Budapest, HungaryDivision of Oncology, Department of Internal Medicine and Oncology, Semmelweis University, 1083 Budapest, HungaryBackground: 1α,25-dihydroxycholecalciferol (1,25(OH)<sub>2</sub>D<sub>3</sub>) and homocysteine are known to play a role in the pathophysiology of colorectal cancer (CRC). In health, the two changes are inversely proportional to each other, but little is known about their combined effect in CRC. Methods: The serum 1,25(OH)<sub>2</sub>D<sub>3</sub> and the homocysteine levels of eighty-six CRC patients were measured, who were enrolled into four cohorts based on the presence of metastases (Adj vs. Met) and vitamin D<sub>3</sub> supplementation (ND vs. D). Results: 1,25(OH)<sub>2</sub>D<sub>3</sub> was constant (Adj-ND), increased significantly (Adj-D, <i>p</i> = 0.0261), decreased (Met-ND), or returned close to the baseline after an initial increase (Met-D). The longitudinal increase in 1,25(OH)<sub>2</sub>D<sub>3</sub> (HR: 0.9130, <i>p</i> = 0.0111) positively affected the overall survival in non-metastatic CRC, however, this effect was cancelled out in those with metastasis (<i>p</i> = 0.0107). The increase in homocysteine negatively affected both the overall (HR: 1.0940, <i>p</i> = 0.0067) and the progression-free survival (HR: 1.0845, <i>p</i> = 0.0073). Lower 1,25(OH)<sub>2</sub>D<sub>3</sub> and/or higher homocysteine level was characteristic for patients with higher serum lipids, albumin, total protein, white blood cell and platelet count, male sex, and right-sided tumors. No statistically justifiable connection was found between the target variables. Conclusions: A measurement-based titration of vitamin D<sub>3</sub> supplementation and better management of comorbidities are recommended for CRC.https://www.mdpi.com/2072-6694/14/3/658vitamin Dhomocysteinecolorectal neoplasmslongitudinal analysissurvival analysis |
| spellingShingle | Dorottya Mühl Magdolna Herold Zoltan Herold Lilla Hornyák Attila Marcell Szasz Magdolna Dank Longitudinal Analysis of 1α,25-dihidroxyvitamin D<sub>3</sub> and Homocysteine Changes in Colorectal Cancer Cancers vitamin D homocysteine colorectal neoplasms longitudinal analysis survival analysis |
| title | Longitudinal Analysis of 1α,25-dihidroxyvitamin D<sub>3</sub> and Homocysteine Changes in Colorectal Cancer |
| title_full | Longitudinal Analysis of 1α,25-dihidroxyvitamin D<sub>3</sub> and Homocysteine Changes in Colorectal Cancer |
| title_fullStr | Longitudinal Analysis of 1α,25-dihidroxyvitamin D<sub>3</sub> and Homocysteine Changes in Colorectal Cancer |
| title_full_unstemmed | Longitudinal Analysis of 1α,25-dihidroxyvitamin D<sub>3</sub> and Homocysteine Changes in Colorectal Cancer |
| title_short | Longitudinal Analysis of 1α,25-dihidroxyvitamin D<sub>3</sub> and Homocysteine Changes in Colorectal Cancer |
| title_sort | longitudinal analysis of 1α 25 dihidroxyvitamin d sub 3 sub and homocysteine changes in colorectal cancer |
| topic | vitamin D homocysteine colorectal neoplasms longitudinal analysis survival analysis |
| url | https://www.mdpi.com/2072-6694/14/3/658 |
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