<i>Bacillus anthracis</i>, “la maladie du charbon”, Toxins, and Institut Pasteur
Institut Pasteur and <i>Bacillus anthracis</i> have enjoyed a relationship lasting almost 120 years, starting from its foundation and the pioneering work of Louis Pasteur in the nascent fields of microbiology and vaccination, and blooming after 1986 following the molecular biology/geneti...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Toxins |
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| Online Access: | https://www.mdpi.com/2072-6651/16/2/66 |
| _version_ | 1797296880246325248 |
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| author | Pierre L. Goossens |
| author_facet | Pierre L. Goossens |
| author_sort | Pierre L. Goossens |
| collection | DOAJ |
| description | Institut Pasteur and <i>Bacillus anthracis</i> have enjoyed a relationship lasting almost 120 years, starting from its foundation and the pioneering work of Louis Pasteur in the nascent fields of microbiology and vaccination, and blooming after 1986 following the molecular biology/genetic revolution. This contribution will give a historical overview of these two research eras, taking advantage of the archives conserved at Institut Pasteur. The first era mainly focused on the production, characterisation, surveillance and improvement of veterinary anthrax vaccines; the concepts and technologies with which to reach a deep understanding of this research field were not yet available. The second period saw a new era of <i>B. anthracis</i> research at Institut Pasteur, with the anthrax laboratory developing a multi-disciplinary approach, ranging from structural analysis, biochemistry, genetic expression, and regulation to bacterial-host cell interactions, <i>in vivo</i> pathogenicity, and therapy development; this led to the comprehensive unravelling of many facets of this toxi-infection. <i>B. anthracis</i> may exemplify some general points on how science is performed in a given society at a given time and how a scientific research domain evolves. A striking illustration can be seen in the additive layers of regulations that were implemented from the beginning of the 21st century and their impact on <i>B. anthracis</i> research. <i>B. anthracis</i> and anthrax are complex systems that raise many valuable questions regarding basic research. One may hope that <i>B. anthracis</i> research will be re-initiated under favourable circumstances later at Institut Pasteur. |
| first_indexed | 2024-03-07T22:12:11Z |
| format | Article |
| id | doaj.art-8a68ff9d94684de9ab6fc6e91e50830c |
| institution | Directory Open Access Journal |
| issn | 2072-6651 |
| language | English |
| last_indexed | 2024-03-07T22:12:11Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Toxins |
| spelling | doaj.art-8a68ff9d94684de9ab6fc6e91e50830c2024-02-23T15:36:30ZengMDPI AGToxins2072-66512024-01-011626610.3390/toxins16020066<i>Bacillus anthracis</i>, “la maladie du charbon”, Toxins, and Institut PasteurPierre L. Goossens0Yersinia, Institut Pasteur, 28 rue du Dr Roux, 75015 Paris, FranceInstitut Pasteur and <i>Bacillus anthracis</i> have enjoyed a relationship lasting almost 120 years, starting from its foundation and the pioneering work of Louis Pasteur in the nascent fields of microbiology and vaccination, and blooming after 1986 following the molecular biology/genetic revolution. This contribution will give a historical overview of these two research eras, taking advantage of the archives conserved at Institut Pasteur. The first era mainly focused on the production, characterisation, surveillance and improvement of veterinary anthrax vaccines; the concepts and technologies with which to reach a deep understanding of this research field were not yet available. The second period saw a new era of <i>B. anthracis</i> research at Institut Pasteur, with the anthrax laboratory developing a multi-disciplinary approach, ranging from structural analysis, biochemistry, genetic expression, and regulation to bacterial-host cell interactions, <i>in vivo</i> pathogenicity, and therapy development; this led to the comprehensive unravelling of many facets of this toxi-infection. <i>B. anthracis</i> may exemplify some general points on how science is performed in a given society at a given time and how a scientific research domain evolves. A striking illustration can be seen in the additive layers of regulations that were implemented from the beginning of the 21st century and their impact on <i>B. anthracis</i> research. <i>B. anthracis</i> and anthrax are complex systems that raise many valuable questions regarding basic research. One may hope that <i>B. anthracis</i> research will be re-initiated under favourable circumstances later at Institut Pasteur.https://www.mdpi.com/2072-6651/16/2/66<i>Bacillus anthracis</i>anthrax<i>anthracis</i> toxinsInstitut Pasteurvaccinesregulations |
| spellingShingle | Pierre L. Goossens <i>Bacillus anthracis</i>, “la maladie du charbon”, Toxins, and Institut Pasteur Toxins <i>Bacillus anthracis</i> anthrax <i>anthracis</i> toxins Institut Pasteur vaccines regulations |
| title | <i>Bacillus anthracis</i>, “la maladie du charbon”, Toxins, and Institut Pasteur |
| title_full | <i>Bacillus anthracis</i>, “la maladie du charbon”, Toxins, and Institut Pasteur |
| title_fullStr | <i>Bacillus anthracis</i>, “la maladie du charbon”, Toxins, and Institut Pasteur |
| title_full_unstemmed | <i>Bacillus anthracis</i>, “la maladie du charbon”, Toxins, and Institut Pasteur |
| title_short | <i>Bacillus anthracis</i>, “la maladie du charbon”, Toxins, and Institut Pasteur |
| title_sort | i bacillus anthracis i la maladie du charbon toxins and institut pasteur |
| topic | <i>Bacillus anthracis</i> anthrax <i>anthracis</i> toxins Institut Pasteur vaccines regulations |
| url | https://www.mdpi.com/2072-6651/16/2/66 |
| work_keys_str_mv | AT pierrelgoossens ibacillusanthracisilamaladieducharbontoxinsandinstitutpasteur |