On the role of autophagy in the progression of differentiated thyroid cancer (literature review)
The aim of the study was to analyze and summarize available literature data on the role of autophagy in thyroid cancer. Material and methods. We analyzed 34 publications available from pubmed and elibrary. Ru databases concerning thyroid cancer and autophagy. Results. The review discussed the role o...
| Main Authors: | , , |
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| Format: | Article |
| Language: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2022-01-01
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| Series: | Сибирский онкологический журнал |
| Subjects: | |
| Online Access: | https://www.siboncoj.ru/jour/article/view/1996 |
| _version_ | 1826563686890733568 |
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| author | K. A. Garipov Z. A. Afanaseva Z. I. Abramova |
| author_facet | K. A. Garipov Z. A. Afanaseva Z. I. Abramova |
| author_sort | K. A. Garipov |
| collection | DOAJ |
| description | The aim of the study was to analyze and summarize available literature data on the role of autophagy in thyroid cancer. Material and methods. We analyzed 34 publications available from pubmed and elibrary. Ru databases concerning thyroid cancer and autophagy. Results. The review discussed the role of autophagy in the progression of thyroid cancer. The development of autophagy-targeted therapy was shown can improve treatment for thyroid cancer. Differentiated thyroid cancer (dtc) is the most common endocrine malignancy. Treatment of dtc patients who are resistant to radioactive iodine therapy is a major challenge. Molecular targeted therapy using tyrosine kinase inhibitors significantly improves treatment outcomes. Conclusion. To enhance the therapeutic effect of treatment with multi-target tyrosine kinase inhibitors, as well as to overcome drug resistance, it is necessary to study the role of autophagy in the development and progression of thyroid cancer. |
| first_indexed | 2024-04-10T01:52:21Z |
| format | Article |
| id | doaj.art-8a6928a094a44b459cb9a364e52f301a |
| institution | Directory Open Access Journal |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| last_indexed | 2025-03-14T10:07:55Z |
| publishDate | 2022-01-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj.art-8a6928a094a44b459cb9a364e52f301a2025-03-02T11:16:15ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682022-01-0120613414010.21294/1814-4861-2021-20-6-134-140932On the role of autophagy in the progression of differentiated thyroid cancer (literature review)K. A. Garipov0Z. A. Afanaseva1Z. I. Abramova2Kazan State Medical Academy – branch of the Russian Medical Academy of Continuing Professional Education; Republican Clinical Cancer Center of Ministry of Health of the Republic of TatarstanKazan State Medical Academy – branch of the Russian Medical Academy of Continuing Professional Education; Republican Clinical Cancer Center of Ministry of Health of the Republic of TatarstanFederal University Kazan (Volga Region) Federal University, Institute of Fundamental Medicine and BiologyThe aim of the study was to analyze and summarize available literature data on the role of autophagy in thyroid cancer. Material and methods. We analyzed 34 publications available from pubmed and elibrary. Ru databases concerning thyroid cancer and autophagy. Results. The review discussed the role of autophagy in the progression of thyroid cancer. The development of autophagy-targeted therapy was shown can improve treatment for thyroid cancer. Differentiated thyroid cancer (dtc) is the most common endocrine malignancy. Treatment of dtc patients who are resistant to radioactive iodine therapy is a major challenge. Molecular targeted therapy using tyrosine kinase inhibitors significantly improves treatment outcomes. Conclusion. To enhance the therapeutic effect of treatment with multi-target tyrosine kinase inhibitors, as well as to overcome drug resistance, it is necessary to study the role of autophagy in the development and progression of thyroid cancer.https://www.siboncoj.ru/jour/article/view/1996dfferentiated thyroid cancerresistance to anticancer therapyautophagymolecular-targeted therapytyrosine kinase inhibitors |
| spellingShingle | K. A. Garipov Z. A. Afanaseva Z. I. Abramova On the role of autophagy in the progression of differentiated thyroid cancer (literature review) Сибирский онкологический журнал dfferentiated thyroid cancer resistance to anticancer therapy autophagy molecular-targeted therapy tyrosine kinase inhibitors |
| title | On the role of autophagy in the progression of differentiated thyroid cancer (literature review) |
| title_full | On the role of autophagy in the progression of differentiated thyroid cancer (literature review) |
| title_fullStr | On the role of autophagy in the progression of differentiated thyroid cancer (literature review) |
| title_full_unstemmed | On the role of autophagy in the progression of differentiated thyroid cancer (literature review) |
| title_short | On the role of autophagy in the progression of differentiated thyroid cancer (literature review) |
| title_sort | on the role of autophagy in the progression of differentiated thyroid cancer literature review |
| topic | dfferentiated thyroid cancer resistance to anticancer therapy autophagy molecular-targeted therapy tyrosine kinase inhibitors |
| url | https://www.siboncoj.ru/jour/article/view/1996 |
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