Hippocampal place cells construct reward related sequences through unexplored space
Dominant theories of hippocampal function propose that place cell representations are formed during an animal's first encounter with a novel environment and are subsequently replayed during off-line states to support consolidation and future behaviour. Here we report that viewing the delivery o...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2015-06-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/06063 |
| _version_ | 1828375132975923200 |
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| author | H Freyja Ólafsdóttir Caswell Barry Aman B Saleem Demis Hassabis Hugo J Spiers |
| author_facet | H Freyja Ólafsdóttir Caswell Barry Aman B Saleem Demis Hassabis Hugo J Spiers |
| author_sort | H Freyja Ólafsdóttir |
| collection | DOAJ |
| description | Dominant theories of hippocampal function propose that place cell representations are formed during an animal's first encounter with a novel environment and are subsequently replayed during off-line states to support consolidation and future behaviour. Here we report that viewing the delivery of food to an unvisited portion of an environment leads to off-line pre-activation of place cells sequences corresponding to that space. Such ‘preplay’ was not observed for an unrewarded but otherwise similar portion of the environment. These results suggest that a hippocampal representation of a visible, yet unexplored environment can be formed if the environment is of motivational relevance to the animal. We hypothesise such goal-biased preplay may support preparation for future experiences in novel environments. |
| first_indexed | 2024-04-14T07:42:16Z |
| format | Article |
| id | doaj.art-8a6a2f7d1a6149959bab5fed80d187c3 |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-14T07:42:16Z |
| publishDate | 2015-06-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-8a6a2f7d1a6149959bab5fed80d187c32022-12-22T02:05:26ZengeLife Sciences Publications LtdeLife2050-084X2015-06-01410.7554/eLife.06063Hippocampal place cells construct reward related sequences through unexplored spaceH Freyja Ólafsdóttir0Caswell Barry1Aman B Saleem2Demis Hassabis3Hugo J Spiers4Institute of Behavioural Neuroscience, Department of Experimental Psychology, Division of Psychology and Language Sciences, University College London, London, United Kingdom; Department of Cell and Developmental Biology, University College London, London, United KingdomDepartment of Cell and Developmental Biology, University College London, London, United KingdomUCL Institute of Ophthalmology, University College London, London, United KingdomGatsby Computational Neuroscience Unit, University College London, London, United KingdomInstitute of Behavioural Neuroscience, Department of Experimental Psychology, Division of Psychology and Language Sciences, University College London, London, United KingdomDominant theories of hippocampal function propose that place cell representations are formed during an animal's first encounter with a novel environment and are subsequently replayed during off-line states to support consolidation and future behaviour. Here we report that viewing the delivery of food to an unvisited portion of an environment leads to off-line pre-activation of place cells sequences corresponding to that space. Such ‘preplay’ was not observed for an unrewarded but otherwise similar portion of the environment. These results suggest that a hippocampal representation of a visible, yet unexplored environment can be formed if the environment is of motivational relevance to the animal. We hypothesise such goal-biased preplay may support preparation for future experiences in novel environments.https://elifesciences.org/articles/06063place cellreplayconsolidationhippocampuspreplayspatial memory |
| spellingShingle | H Freyja Ólafsdóttir Caswell Barry Aman B Saleem Demis Hassabis Hugo J Spiers Hippocampal place cells construct reward related sequences through unexplored space eLife place cell replay consolidation hippocampus preplay spatial memory |
| title | Hippocampal place cells construct reward related sequences through unexplored space |
| title_full | Hippocampal place cells construct reward related sequences through unexplored space |
| title_fullStr | Hippocampal place cells construct reward related sequences through unexplored space |
| title_full_unstemmed | Hippocampal place cells construct reward related sequences through unexplored space |
| title_short | Hippocampal place cells construct reward related sequences through unexplored space |
| title_sort | hippocampal place cells construct reward related sequences through unexplored space |
| topic | place cell replay consolidation hippocampus preplay spatial memory |
| url | https://elifesciences.org/articles/06063 |
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