TDP-43-stratified single-cell proteomics of postmortem human spinal motor neurons reveals protein dynamics in amyotrophic lateral sclerosis

TDP-43-stratified single-cell proteomics of postmortem human spinal motor neurons reveals protein dynamics in amyotrophic lateral sclerosis

Summary: A limitation of conventional bulk-tissue proteome studies in amyotrophic lateral sclerosis (ALS) is the confounding of motor neuron (MN) signals by admixed non-MN proteins. Here, we leverage laser capture microdissection and nanoPOTS single-cell mass spectrometry-based proteomics to query c...

Celý popis

Podrobná bibliografie
Hlavní autoři: Amanda J. Guise, Santosh A. Misal, Richard Carson, Jen-Hwa Chu, Hannah Boekweg, Daisha Van Der Watt, Nora C. Welsh, Thy Truong, Yiran Liang, Shanqin Xu, Gina Benedetto, Jake Gagnon, Samuel H. Payne, Edward D. Plowey, Ryan T. Kelly
Médium: Článek
Jazyk:English
Vydáno: Elsevier 2024-01-01
Edice:Cell Reports
Témata:
CP: Neuroscience
CP: Molecular biology
On-line přístup:http://www.sciencedirect.com/science/article/pii/S2211124723016479

Internet

http://www.sciencedirect.com/science/article/pii/S2211124723016479

Podobné jednotky