TDP-43-stratified single-cell proteomics of postmortem human spinal motor neurons reveals protein dynamics in amyotrophic lateral sclerosis

TDP-43-stratified single-cell proteomics of postmortem human spinal motor neurons reveals protein dynamics in amyotrophic lateral sclerosis

Summary: A limitation of conventional bulk-tissue proteome studies in amyotrophic lateral sclerosis (ALS) is the confounding of motor neuron (MN) signals by admixed non-MN proteins. Here, we leverage laser capture microdissection and nanoPOTS single-cell mass spectrometry-based proteomics to query c...

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Main Authors: Amanda J. Guise, Santosh A. Misal, Richard Carson, Jen-Hwa Chu, Hannah Boekweg, Daisha Van Der Watt, Nora C. Welsh, Thy Truong, Yiran Liang, Shanqin Xu, Gina Benedetto, Jake Gagnon, Samuel H. Payne, Edward D. Plowey, Ryan T. Kelly
格式: 文件
语言:English
出版: Elsevier 2024-01-01
丛编:Cell Reports
主题:
CP: Neuroscience
CP: Molecular biology
在线阅读:http://www.sciencedirect.com/science/article/pii/S2211124723016479

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http://www.sciencedirect.com/science/article/pii/S2211124723016479

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