Clinical Tick-Borne Encephalitis in a Roe Deer (<i>Capreolus capreolus</i> L.)
<i>Tick-borne encephalitis virus</i> (TBEV) is the causative agent of tick-borne encephalitis (TBE), a severe zoonosis occurring in the Palearctic region mainly transmitted through <i>Ixodes</i> ticks. In Italy, TBEV is restricted to the north-eastern part of the country. Thi...
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MDPI AG
2022-01-01
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Online Access: | https://www.mdpi.com/1999-4915/14/2/300 |
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author | Graziana Da Rold Federica Obber Isabella Monne Adelaide Milani Silvia Ravagnan Federica Toniolo Sofia Sgubin Gianpiero Zamperin Greta Foiani Marta Vascellari Petra Drzewniokova Martina Castellan Paola De Benedictis Carlo Vittorio Citterio |
author_facet | Graziana Da Rold Federica Obber Isabella Monne Adelaide Milani Silvia Ravagnan Federica Toniolo Sofia Sgubin Gianpiero Zamperin Greta Foiani Marta Vascellari Petra Drzewniokova Martina Castellan Paola De Benedictis Carlo Vittorio Citterio |
author_sort | Graziana Da Rold |
collection | DOAJ |
description | <i>Tick-borne encephalitis virus</i> (TBEV) is the causative agent of tick-borne encephalitis (TBE), a severe zoonosis occurring in the Palearctic region mainly transmitted through <i>Ixodes</i> ticks. In Italy, TBEV is restricted to the north-eastern part of the country. This report describes for the first time a case of clinical TBE in a roe deer (<i>Capreolus capreolus</i> L.). The case occurred in the Belluno province, Veneto region, an area endemic for TBEV. The affected roe deer showed ataxia, staggering movements, muscle tremors, wide-base stance of the front limbs, repetitive movements of the head, persistent teeth grinding, hypersalivation and prolonged recumbency. An autopsy revealed no significant lesions to explain the neurological signs. TBEV RNA was detected in the brain by real-time RT-PCR, and the nearly complete viral genome (10,897 nucleotides) was sequenced. Phylogenetic analysis of the gene encoding the envelope protein revealed a close relationship to TBEV of the European subtype, and 100% similarity with a partial sequence (520 nucleotides) of a TBEV found in ticks in the bordering Trento province. The histological examination of the midbrain revealed lymphohistiocytic encephalitis, satellitosis and microgliosis, consistent with a viral etiology. Other viral etiologies were ruled out by metagenomic analysis of the brain. This report underlines, for the first time, the occurrence of clinical encephalitic manifestations due to TBEV in a roe deer, suggesting that this pathogen should be included in the frame of differential diagnoses in roe deer with neurologic disease. |
first_indexed | 2024-03-09T20:52:42Z |
format | Article |
id | doaj.art-8a6b0fcf132e443fb4c9cd0244f9ee6f |
institution | Directory Open Access Journal |
issn | 1999-4915 |
language | English |
last_indexed | 2024-03-09T20:52:42Z |
publishDate | 2022-01-01 |
publisher | MDPI AG |
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series | Viruses |
spelling | doaj.art-8a6b0fcf132e443fb4c9cd0244f9ee6f2023-11-23T22:30:39ZengMDPI AGViruses1999-49152022-01-0114230010.3390/v14020300Clinical Tick-Borne Encephalitis in a Roe Deer (<i>Capreolus capreolus</i> L.)Graziana Da Rold0Federica Obber1Isabella Monne2Adelaide Milani3Silvia Ravagnan4Federica Toniolo5Sofia Sgubin6Gianpiero Zamperin7Greta Foiani8Marta Vascellari9Petra Drzewniokova10Martina Castellan11Paola De Benedictis12Carlo Vittorio Citterio13U.O. Ecopathology SCT2-Belluno, Istituto Zoprofilattico Sperimentale delle Venezie (IZSVe), Via Cappellari 44/A, 32100 Belluno, ItalyU.O. Ecopathology SCT2-Belluno, Istituto Zoprofilattico Sperimentale delle Venezie (IZSVe), Via Cappellari 44/A, 32100 Belluno, ItalyOIE Collaborating Centre for Diseases at the Animal/Human Interface, Istituto Zooprofilattico Sperimentale delle Venezie (IZSVe), Viale dell’Università 10, 35020 Legnaro, ItalyOIE Collaborating Centre for Diseases at the Animal/Human Interface, Istituto Zooprofilattico Sperimentale delle Venezie (IZSVe), Viale dell’Università 10, 35020 Legnaro, ItalyOIE Collaborating Centre for Diseases at the Animal/Human Interface, Istituto Zooprofilattico Sperimentale delle Venezie (IZSVe), Viale dell’Università 10, 35020 Legnaro, ItalyOIE Collaborating Centre for Diseases at the Animal/Human Interface, Istituto Zooprofilattico Sperimentale delle Venezie (IZSVe), Viale dell’Università 10, 35020 Legnaro, ItalyOIE Collaborating Centre for Diseases at the Animal/Human Interface, Istituto Zooprofilattico Sperimentale delle Venezie (IZSVe), Viale dell’Università 10, 35020 Legnaro, ItalyOIE Collaborating Centre for Diseases at the Animal/Human Interface, Istituto Zooprofilattico Sperimentale delle Venezie (IZSVe), Viale dell’Università 10, 35020 Legnaro, ItalyOIE Collaborating Centre for Diseases at the Animal/Human Interface, Istituto Zooprofilattico Sperimentale delle Venezie (IZSVe), Viale dell’Università 10, 35020 Legnaro, ItalyOIE Collaborating Centre for Diseases at the Animal/Human Interface, Istituto Zooprofilattico Sperimentale delle Venezie (IZSVe), Viale dell’Università 10, 35020 Legnaro, ItalyOIE Collaborating Centre for Diseases at the Animal/Human Interface, Istituto Zooprofilattico Sperimentale delle Venezie (IZSVe), Viale dell’Università 10, 35020 Legnaro, ItalyOIE Collaborating Centre for Diseases at the Animal/Human Interface, Istituto Zooprofilattico Sperimentale delle Venezie (IZSVe), Viale dell’Università 10, 35020 Legnaro, ItalyOIE Collaborating Centre for Diseases at the Animal/Human Interface, Istituto Zooprofilattico Sperimentale delle Venezie (IZSVe), Viale dell’Università 10, 35020 Legnaro, ItalyU.O. Ecopathology SCT2-Belluno, Istituto Zoprofilattico Sperimentale delle Venezie (IZSVe), Via Cappellari 44/A, 32100 Belluno, Italy<i>Tick-borne encephalitis virus</i> (TBEV) is the causative agent of tick-borne encephalitis (TBE), a severe zoonosis occurring in the Palearctic region mainly transmitted through <i>Ixodes</i> ticks. In Italy, TBEV is restricted to the north-eastern part of the country. This report describes for the first time a case of clinical TBE in a roe deer (<i>Capreolus capreolus</i> L.). The case occurred in the Belluno province, Veneto region, an area endemic for TBEV. The affected roe deer showed ataxia, staggering movements, muscle tremors, wide-base stance of the front limbs, repetitive movements of the head, persistent teeth grinding, hypersalivation and prolonged recumbency. An autopsy revealed no significant lesions to explain the neurological signs. TBEV RNA was detected in the brain by real-time RT-PCR, and the nearly complete viral genome (10,897 nucleotides) was sequenced. Phylogenetic analysis of the gene encoding the envelope protein revealed a close relationship to TBEV of the European subtype, and 100% similarity with a partial sequence (520 nucleotides) of a TBEV found in ticks in the bordering Trento province. The histological examination of the midbrain revealed lymphohistiocytic encephalitis, satellitosis and microgliosis, consistent with a viral etiology. Other viral etiologies were ruled out by metagenomic analysis of the brain. This report underlines, for the first time, the occurrence of clinical encephalitic manifestations due to TBEV in a roe deer, suggesting that this pathogen should be included in the frame of differential diagnoses in roe deer with neurologic disease.https://www.mdpi.com/1999-4915/14/2/300roe deertick-borne encephalitisneurologic diseasepathologygenetic characterization |
spellingShingle | Graziana Da Rold Federica Obber Isabella Monne Adelaide Milani Silvia Ravagnan Federica Toniolo Sofia Sgubin Gianpiero Zamperin Greta Foiani Marta Vascellari Petra Drzewniokova Martina Castellan Paola De Benedictis Carlo Vittorio Citterio Clinical Tick-Borne Encephalitis in a Roe Deer (<i>Capreolus capreolus</i> L.) Viruses roe deer tick-borne encephalitis neurologic disease pathology genetic characterization |
title | Clinical Tick-Borne Encephalitis in a Roe Deer (<i>Capreolus capreolus</i> L.) |
title_full | Clinical Tick-Borne Encephalitis in a Roe Deer (<i>Capreolus capreolus</i> L.) |
title_fullStr | Clinical Tick-Borne Encephalitis in a Roe Deer (<i>Capreolus capreolus</i> L.) |
title_full_unstemmed | Clinical Tick-Borne Encephalitis in a Roe Deer (<i>Capreolus capreolus</i> L.) |
title_short | Clinical Tick-Borne Encephalitis in a Roe Deer (<i>Capreolus capreolus</i> L.) |
title_sort | clinical tick borne encephalitis in a roe deer i capreolus capreolus i l |
topic | roe deer tick-borne encephalitis neurologic disease pathology genetic characterization |
url | https://www.mdpi.com/1999-4915/14/2/300 |
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