Nitric oxide in liver fibrosis: The role of inducible nitric oxide synthase
The inducible form of nitric oxide synthase (iNOS) is expressed in hepatic cells in pathological conditions. Its induction is involved in the development of liver fibrosis, and thus iNOS could be a therapeutic target for liver fibrosis. This review summarizes the role of iNOS in liver fibrosis, focu...
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| Format: | Article |
| Language: | English |
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Korean Association for the Study of the Liver
2015-12-01
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| Series: | Clinical and Molecular Hepatology |
| Subjects: | |
| Online Access: | http://e-cmh.org/upload/pdf/cmh-21-319.pdf |
| _version_ | 1828796986938097664 |
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| author | Yasuko Iwakiri |
| author_facet | Yasuko Iwakiri |
| author_sort | Yasuko Iwakiri |
| collection | DOAJ |
| description | The inducible form of nitric oxide synthase (iNOS) is expressed in hepatic cells in pathological conditions. Its induction is involved in the development of liver fibrosis, and thus iNOS could be a therapeutic target for liver fibrosis. This review summarizes the role of iNOS in liver fibrosis, focusing on 1) iNOS biology, 2) iNOS-expressing liver cells, 3) iNOS-related therapeutic strategies, and 4) future directions. |
| first_indexed | 2024-12-12T04:32:40Z |
| format | Article |
| id | doaj.art-8a6b78bb5291460f88d6ce7160732fc9 |
| institution | Directory Open Access Journal |
| issn | 2287-2728 2287-285X |
| language | English |
| last_indexed | 2024-12-12T04:32:40Z |
| publishDate | 2015-12-01 |
| publisher | Korean Association for the Study of the Liver |
| record_format | Article |
| series | Clinical and Molecular Hepatology |
| spelling | doaj.art-8a6b78bb5291460f88d6ce7160732fc92022-12-22T00:38:02ZengKorean Association for the Study of the LiverClinical and Molecular Hepatology2287-27282287-285X2015-12-0121431932510.3350/cmh.2015.21.4.3191158Nitric oxide in liver fibrosis: The role of inducible nitric oxide synthaseYasuko Iwakiri0Department of Internal Medicine, Section of Digestive Diseases, Yale University School of Medicine, New Haven, CT, USA.The inducible form of nitric oxide synthase (iNOS) is expressed in hepatic cells in pathological conditions. Its induction is involved in the development of liver fibrosis, and thus iNOS could be a therapeutic target for liver fibrosis. This review summarizes the role of iNOS in liver fibrosis, focusing on 1) iNOS biology, 2) iNOS-expressing liver cells, 3) iNOS-related therapeutic strategies, and 4) future directions.http://e-cmh.org/upload/pdf/cmh-21-319.pdfiNOSNOLiver sinusoidal endothelial cellHepatic stellate cellKupffer cell |
| spellingShingle | Yasuko Iwakiri Nitric oxide in liver fibrosis: The role of inducible nitric oxide synthase Clinical and Molecular Hepatology iNOS NO Liver sinusoidal endothelial cell Hepatic stellate cell Kupffer cell |
| title | Nitric oxide in liver fibrosis: The role of inducible nitric oxide synthase |
| title_full | Nitric oxide in liver fibrosis: The role of inducible nitric oxide synthase |
| title_fullStr | Nitric oxide in liver fibrosis: The role of inducible nitric oxide synthase |
| title_full_unstemmed | Nitric oxide in liver fibrosis: The role of inducible nitric oxide synthase |
| title_short | Nitric oxide in liver fibrosis: The role of inducible nitric oxide synthase |
| title_sort | nitric oxide in liver fibrosis the role of inducible nitric oxide synthase |
| topic | iNOS NO Liver sinusoidal endothelial cell Hepatic stellate cell Kupffer cell |
| url | http://e-cmh.org/upload/pdf/cmh-21-319.pdf |
| work_keys_str_mv | AT yasukoiwakiri nitricoxideinliverfibrosistheroleofinduciblenitricoxidesynthase |