Transcriptional Landscape of a blaKPC-2 Plasmid and Response to Imipenem Exposure in Escherichia coli TOP10

Transcriptional Landscape of a blaKPC-2 Plasmid and Response to Imipenem Exposure in Escherichia coli TOP10

The diffusion of KPC-2 carbapenemase is closely related to the spread of Klebsiella pneumoniae of the clonal-group 258 and linked to IncFIIK plasmids. Little is known about the biology of multi-drug resistant plasmids and the reasons of their successful dissemination. Using E. coli TOP10 strain harb...

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Bibliographic Details
Main Authors: Agnès B. Jousset, Isabelle Rosinski-Chupin, Julie Takissian, Philippe Glaser, Rémy A. Bonnin, Thierry Naas
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Microbiology
Subjects:
carbapenemase
KPC-producing plasmids
transcriptome
RNA-seq
oxidative-stress
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.02929/full

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