Smoking is an Independent Marker of Poor Prognosis in Cutaneous Melanoma
Previous studies have suggested that persistent tobacco smoking impairs survival in cutaneous melanoma, but the effects of smoking and other prognostic factors have not been described in detail. This study examined the association of smoking (persistent, former, or never) with melanoma-specific (MSS...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Medical Journals Sweden
2023-02-01
|
| Series: | Acta Dermato-Venereologica |
| Subjects: | |
| Online Access: | https://medicaljournalssweden.se/actadv/article/view/3209 |
| _version_ | 1811170278418415616 |
|---|---|
| author | Kalle Mattila Helmi Vihinen Antti Karlsson Heikki Minn Pia Vihinen Eetu Heervä |
| author_facet | Kalle Mattila Helmi Vihinen Antti Karlsson Heikki Minn Pia Vihinen Eetu Heervä |
| author_sort | Kalle Mattila |
| collection | DOAJ |
| description | Previous studies have suggested that persistent tobacco smoking impairs survival in cutaneous melanoma, but the effects of smoking and other prognostic factors have not been described in detail. This study examined the association of smoking (persistent, former, or never) with melanoma-specific (MSS) and overall survival (OS) in patients with cutaneous melanoma treated in Southwest Finland during 2005 to 2019. Clinical characteristics were obtained from electronic health records for 1,980 patients. Smoking status was available for 1,359 patients. Patients were restaged according to the 8th edition of the tumour-node-metastasis (TNM) classification. Smoking remained an independent prognostic factor for inferior melanoma-specific survival regardless of age, sex, stage, and comorbidities. The hazard ratio of death from melanoma was 1.81 (1.27−2.58, p = 0.001) in persistent and 1.75 (1.28−2.40, p = 0.001) in former smokers compared with never smokers. In 351 stage IV patients, smoking was associated with increased melanoma-specific and overall mortality: median MSS 10.4 (6.5−14.3), 14.6 (9.1−20.1), and 14.9 (11.4−18.4) months, p = 0.01 and median OS 10.4 (6.5−14.3), 13.9 (8.6−19.2), and 14.9 (11.7−18.1) months, p = 0.01 in persistent, former, and never smokers, respectively. In conclusion, since smoking represents an independent modifiable poor prognostic factor in patients with cutaneous melanoma, smoking habits should be proactively asked about by healthcare professionals, in order to support smoking cessation.
|
| first_indexed | 2024-04-10T16:55:23Z |
| format | Article |
| id | doaj.art-8a6ed2ba966c48ec87a292d510f66a59 |
| institution | Directory Open Access Journal |
| issn | 0001-5555 1651-2057 |
| language | English |
| last_indexed | 2024-04-10T16:55:23Z |
| publishDate | 2023-02-01 |
| publisher | Medical Journals Sweden |
| record_format | Article |
| series | Acta Dermato-Venereologica |
| spelling | doaj.art-8a6ed2ba966c48ec87a292d510f66a592023-02-07T08:16:32ZengMedical Journals SwedenActa Dermato-Venereologica0001-55551651-20572023-02-0110310.2340/actadv.v103.3209Smoking is an Independent Marker of Poor Prognosis in Cutaneous MelanomaKalle Mattila0Helmi Vihinen1Antti Karlsson2Heikki Minn3Pia Vihinen4Eetu Heervä5Department of Oncology and FICAN West Cancer Centre, Turku University Hospital and University of Turku, Turku, Finland; InFLAMES Research Flagship Center, University of Turku, Turku, FinlandTurku School of Economics, University of Turku, Turku, FinlandAuria Biobank and Turku University Hospital, Turku FinlandDepartment of Oncology and FICAN West Cancer Centre, Turku University Hospital and University of Turku, Turku, FinlandDepartment of Oncology and FICAN West Cancer Centre, Turku University Hospital and University of Turku, Turku, FinlandDepartment of Oncology and FICAN West Cancer Centre, Turku University Hospital and University of Turku, Turku, FinlandPrevious studies have suggested that persistent tobacco smoking impairs survival in cutaneous melanoma, but the effects of smoking and other prognostic factors have not been described in detail. This study examined the association of smoking (persistent, former, or never) with melanoma-specific (MSS) and overall survival (OS) in patients with cutaneous melanoma treated in Southwest Finland during 2005 to 2019. Clinical characteristics were obtained from electronic health records for 1,980 patients. Smoking status was available for 1,359 patients. Patients were restaged according to the 8th edition of the tumour-node-metastasis (TNM) classification. Smoking remained an independent prognostic factor for inferior melanoma-specific survival regardless of age, sex, stage, and comorbidities. The hazard ratio of death from melanoma was 1.81 (1.27−2.58, p = 0.001) in persistent and 1.75 (1.28−2.40, p = 0.001) in former smokers compared with never smokers. In 351 stage IV patients, smoking was associated with increased melanoma-specific and overall mortality: median MSS 10.4 (6.5−14.3), 14.6 (9.1−20.1), and 14.9 (11.4−18.4) months, p = 0.01 and median OS 10.4 (6.5−14.3), 13.9 (8.6−19.2), and 14.9 (11.7−18.1) months, p = 0.01 in persistent, former, and never smokers, respectively. In conclusion, since smoking represents an independent modifiable poor prognostic factor in patients with cutaneous melanoma, smoking habits should be proactively asked about by healthcare professionals, in order to support smoking cessation. https://medicaljournalssweden.se/actadv/article/view/3209cigarettemelanomametastasisskin cancersmokingsurvival |
| spellingShingle | Kalle Mattila Helmi Vihinen Antti Karlsson Heikki Minn Pia Vihinen Eetu Heervä Smoking is an Independent Marker of Poor Prognosis in Cutaneous Melanoma Acta Dermato-Venereologica cigarette melanoma metastasis skin cancer smoking survival |
| title | Smoking is an Independent Marker of Poor Prognosis in Cutaneous Melanoma |
| title_full | Smoking is an Independent Marker of Poor Prognosis in Cutaneous Melanoma |
| title_fullStr | Smoking is an Independent Marker of Poor Prognosis in Cutaneous Melanoma |
| title_full_unstemmed | Smoking is an Independent Marker of Poor Prognosis in Cutaneous Melanoma |
| title_short | Smoking is an Independent Marker of Poor Prognosis in Cutaneous Melanoma |
| title_sort | smoking is an independent marker of poor prognosis in cutaneous melanoma |
| topic | cigarette melanoma metastasis skin cancer smoking survival |
| url | https://medicaljournalssweden.se/actadv/article/view/3209 |
| work_keys_str_mv | AT kallemattila smokingisanindependentmarkerofpoorprognosisincutaneousmelanoma AT helmivihinen smokingisanindependentmarkerofpoorprognosisincutaneousmelanoma AT anttikarlsson smokingisanindependentmarkerofpoorprognosisincutaneousmelanoma AT heikkiminn smokingisanindependentmarkerofpoorprognosisincutaneousmelanoma AT piavihinen smokingisanindependentmarkerofpoorprognosisincutaneousmelanoma AT eetuheerva smokingisanindependentmarkerofpoorprognosisincutaneousmelanoma |