Association between apolipoprotein E polymorphism and nephropathy in Iranian diabetic patients
Approximately one-third of diabetic patients develop evidence of nephropathy. Pathogenesis of diabetic nephropathy (DN) remains unclear; however, some genetic and metabolic risk factors have been determined for the development and progression of DN. In the recent genetic studies, polymorphism of apo...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2017-01-01
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| Series: | Saudi Journal of Kidney Diseases and Transplantation |
| Online Access: | http://www.sjkdt.org/article.asp?issn=1319-2442;year=2017;volume=28;issue=5;spage=997;epage=1002;aulast=Karimoei |
| _version_ | 1798044994335932416 |
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| author | Mostafa Karimoei Parvin Pasalar Mohsen Mehrabzadeh Maryam Daneshpour Maryam Shojaee Katayoun Forouzanfar Farideh Razi |
| author_facet | Mostafa Karimoei Parvin Pasalar Mohsen Mehrabzadeh Maryam Daneshpour Maryam Shojaee Katayoun Forouzanfar Farideh Razi |
| author_sort | Mostafa Karimoei |
| collection | DOAJ |
| description | Approximately one-third of diabetic patients develop evidence of nephropathy. Pathogenesis of diabetic nephropathy (DN) remains unclear; however, some genetic and metabolic risk factors have been determined for the development and progression of DN. In the recent genetic studies, polymorphism of apolipoprotein E (ApoE) gene has been reported as a risk factor for the development of DN; however, the results are inconsistent. The aim of the present study was to evaluate the association between ApoE polymorphism and nephropathy in Iranian patient with type 2 diabetes. A total of 197 patients with type 2 diabetes in two groups with and without nephropathy (n = 99 and n = 98, respectively) participated in this case–control study. ApoE genotype was determined by restriction fragment length polymorphism analysis. Biochemical factors of all patients were measured. The frequency of Apo ε4 allele was significantly (P <0.05) lower in DN patients (10.6%) than in diabetic patients without nephropathy (20.4%). No significant difference was observed between the groups regarding Apo ε2 and Apo ε3 allele frequencies. Serum level of total and low-density lipoprotein cholesterol in Apo ε2 carriers was lower than Apo ε3 and Apo ε4 carriers, but this difference was not statistically significant. Frequency of Apo ε4 allele is higher in diabetic patients without nephropathy than DN participants. Given to the result, it seems that Apo ε4 has a protective effect in diabetic patients against nephropathy. |
| first_indexed | 2024-04-11T23:13:22Z |
| format | Article |
| id | doaj.art-8a6fe0b3a3804d998a379315ff8029f3 |
| institution | Directory Open Access Journal |
| issn | 1319-2442 |
| language | English |
| last_indexed | 2024-04-11T23:13:22Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Saudi Journal of Kidney Diseases and Transplantation |
| spelling | doaj.art-8a6fe0b3a3804d998a379315ff8029f32022-12-22T03:57:42ZengWolters Kluwer Medknow PublicationsSaudi Journal of Kidney Diseases and Transplantation1319-24422017-01-01285997100210.4103/1319-2442.215137Association between apolipoprotein E polymorphism and nephropathy in Iranian diabetic patientsMostafa KarimoeiParvin PasalarMohsen MehrabzadehMaryam DaneshpourMaryam ShojaeeKatayoun ForouzanfarFarideh RaziApproximately one-third of diabetic patients develop evidence of nephropathy. Pathogenesis of diabetic nephropathy (DN) remains unclear; however, some genetic and metabolic risk factors have been determined for the development and progression of DN. In the recent genetic studies, polymorphism of apolipoprotein E (ApoE) gene has been reported as a risk factor for the development of DN; however, the results are inconsistent. The aim of the present study was to evaluate the association between ApoE polymorphism and nephropathy in Iranian patient with type 2 diabetes. A total of 197 patients with type 2 diabetes in two groups with and without nephropathy (n = 99 and n = 98, respectively) participated in this case–control study. ApoE genotype was determined by restriction fragment length polymorphism analysis. Biochemical factors of all patients were measured. The frequency of Apo ε4 allele was significantly (P <0.05) lower in DN patients (10.6%) than in diabetic patients without nephropathy (20.4%). No significant difference was observed between the groups regarding Apo ε2 and Apo ε3 allele frequencies. Serum level of total and low-density lipoprotein cholesterol in Apo ε2 carriers was lower than Apo ε3 and Apo ε4 carriers, but this difference was not statistically significant. Frequency of Apo ε4 allele is higher in diabetic patients without nephropathy than DN participants. Given to the result, it seems that Apo ε4 has a protective effect in diabetic patients against nephropathy.http://www.sjkdt.org/article.asp?issn=1319-2442;year=2017;volume=28;issue=5;spage=997;epage=1002;aulast=Karimoei |
| spellingShingle | Mostafa Karimoei Parvin Pasalar Mohsen Mehrabzadeh Maryam Daneshpour Maryam Shojaee Katayoun Forouzanfar Farideh Razi Association between apolipoprotein E polymorphism and nephropathy in Iranian diabetic patients Saudi Journal of Kidney Diseases and Transplantation |
| title | Association between apolipoprotein E polymorphism and nephropathy in Iranian diabetic patients |
| title_full | Association between apolipoprotein E polymorphism and nephropathy in Iranian diabetic patients |
| title_fullStr | Association between apolipoprotein E polymorphism and nephropathy in Iranian diabetic patients |
| title_full_unstemmed | Association between apolipoprotein E polymorphism and nephropathy in Iranian diabetic patients |
| title_short | Association between apolipoprotein E polymorphism and nephropathy in Iranian diabetic patients |
| title_sort | association between apolipoprotein e polymorphism and nephropathy in iranian diabetic patients |
| url | http://www.sjkdt.org/article.asp?issn=1319-2442;year=2017;volume=28;issue=5;spage=997;epage=1002;aulast=Karimoei |
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